Evaluation Effects of Spray-dried Egg Protein Containing Specific Egg Yolk Antibodies as a Substitute for Spray-dried Plasma Protein or Antibiotics in Weaned Pigs

Abstract

In Exp. 1, a total of 36 pigs (6.55±0.10 kg average initial body weight and 21 d average age) were used in a 14 d growth study to determine the effects of replacing spray-dried plasma protein (SDPP) with spray-dried egg protein containing specific egg yolk antibody (SDEP) on growth performance and nutrient digestibility in weaned pigs. The pigs were blocked by weight and assigned to treatments based on sex. There were three pigs per pen and four pens per treatment. Dietary treatments were 0, 3, or 6% SDEP and contained 6, 3, or 0% SDPP, respectively. Through the entire experimental period, average daily gain (ADG), average daily feed intake (ADFI), and gain/feed tended to decrease as the concentration of SDEP increased in the diets. However, there were no significant differences among the treatments (p>0.05). As the addition of SDEP in the diets increased, apparent digestibilities of dry matter (DM) and nitrogen (N) were decreased without significant (p>0.05). For Exp. 2, 36 pigs (2.63±0.04 kg average initial body weight and 10 d average age) were used in a 14 d growth study to determine the effects of antibiotic replacement with SDEP on growth performance and nutrient digestibility in early-weaned pigs. The pigs were blocked by weight and assigned to treatments based on sex. There were three pigs per pen and four pens per treatment. Dietary treatments included 1) ANTIBIOTIC (corn-dried whey-soybean meal based diet+0.08% antibiotics, 4 mg of tiamuline hydrogen fumarate; 10 mg of sulfadimidine per kg of complete diet), 2) SDEP0.1 (corndried whey-SBM based diet+0.1% SDEP), and 3) SDEP0.2 (corn-dried whey-SBM based diet+0.2% SDEP). ADG and gain/feed of pigs fed the SDEP0.2 diet were higher than for pigs fed the ANTIBIOTIC diet without significant (p>0.05). Pigs fed the diet with SDEP0.2 tended to have increased apparent digestibilities of DM and N compared to pigs fed the ANTIBIOTIC diet without significant (p>0.05). In conclusion, the dietary SDEP seemed to be partial replacing the SDPP portion of high nutrient dense diet for weaned pigs. Also, dietary SDEP seemed to be approximately 0.2% or more when the pigs fed the antibiotic-free diet for early-weaned pigs.

Alternatives to antibiotics as growth promoters for use in swine production: a review

“…Unfortunately, there are several reports where egg yolk antibody failed to improve pig performance [ 42 , 44 ]. The most likely explanation for the failure of egg yolk antibody to improve performance is that the antibody failed to survive passage through the gastrointestinal tract [ 45 ].…”

Prevalence of Fimbrial Antigen (K88 variants, K99 and 987P) of Enterotoxigenic Escherichia Coli from Neonatal and Post-weaning Piglets with Diarrhea in Central China

“…Because of increased incidence of antibiotic resistance in microorganisms and the pressure by regulatory agents to ban or greatly restrict the use of antibiotics in the feed industry, alternative strategies are needed to control this intestinal disease. Using therapeutic antibodies, such as egg yolk antibodies to anti-frimbrial antigens, was reported as one effective alternative approach to control E. coli-induced diarrhea (Marquart et al, 1999;Owusu et al, 2003;Hong et al, 2004). Therefore, determination of the target antigen, as the first step for producing the specific therapeutic antibodies against ETEC, is very necessary.…”

Effect of chicken egg yolk immunoglobulins on serum biochemical profiles and intestinal bacterial populations in early‐weaned piglets

“…In order to prevent or treat enteric infections, IgY must resist degradation and reach the small intestine without activity loss (Hong et al, 2004). Several strategies to protect IgY from hydrolysis have been developed including liposomes (Chang, Lee, Chen, & Tu, 2002), polymeric microspheres (Torche et al, 2006) and multiple emulsifications (Cho et al, 2005).…”