Evaluation of 2‐benzylidenecyclohexanones and 2,6‐bis(benzylidene)cyclohexanones for antitumor and cytotoxic activity and as inhibitors of mitochondrial function in yeast: Metabolism studies of (E)‐2‐benzylidenecyclohexanone

Cytotoxic and Topographical Properties of 6-Arylidene-2-dimethylaminomethylcyclohexanone Hydrochlorides and Related Compounds

“…4 Since thiols are absent in nucleic acids, these compounds may be devoid of the genotoxic properties associated with a number of anticancer drugs. In particular, various 2-arylidenecyclohexanones displayed cytotoxicity towards human epidermoid carcinoma of the nasopharynx, 5 and recently the growth-inhibiting properties of (1a,c,d,f,g) towards murine P388 and L1210 cells as well as human Molt 4/C8 and CEM T-lymphocytes was described. 6 The synthesis of (1i) was suggested based on the recent observations of the significant cytotoxic potencies of various conjugated arylidene enones containing a 4-nitrophenyl group.…”

Evaluation of substituted methyl cyclohexanone hybrids for anti-tubercular, anti-bacterial and anti-fungal activity: Facile syntheses under catalysis by ionic liquids

“…The cycloalkanones are found to be versatile antimicrobial agents possessing drug resistance reversal [13], cytotoxicity [14], and histone acetyl transferase [15] properties. Due to the unique biological and pharmacological activity, thiazoles have attracted considerable attention.…”

A facile synthesis of α,α′-(EE)-bis(benzylidene)-cycloalkanones and their antitubercular evaluations

“…Moreover, several acetophenones [12], chalcones [13] and Mannich bases of benzylidene cycloalkanones [14] have also been disclosed to possess moderate antitubercular activity and their mode of action is also postulated to be the inhibition of initial steps in fatty acid biosynthesis. Bis-benzylidene cycloalkanones have been reported to possess drug resistance reversal [15], cytotoxicity [16] and histone acetyl transferase (HAT) [17] inhibitory activities. N-Acetyl transferase (NAT), a subtype of HAT plays a very important role in the initial stages of mycolic acid biosynthesis in mycobacterium and it is known that human NAT inactivates [18] the antitubercular drug INH (isoniazid) in humans.…”

“…On the other hand compounds 2,5,9,16,18,19 and 21 show activity against M. tuberculosis H37Rv. Therefore, two of the above compounds 2 and 5 are active against both the avirulent and virulent strains of M. tuberculosis.Among all the compounds screened against different strains of bacteria and fungi only one compound (compound 2) showed activity against the two fungi, S. schenckii and T. mentagrophytes with MIC ¼ 25 and 12.5 mg/mL, respectively.…”