Evaluation of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography in gastric carcinoma: relation to histological subtypes, depth of tumor invasion, and glucose transporter-1 expression

Yamada, Akira; Oguchi, Kazuhiro; Fukushima, Mana; Imai, Yutaka; Kadoya, Masumi

doi:10.1007/bf02984657

Cited by 97 publications

(91 citation statements)

References 19 publications

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“…In the present study, 42% of GSRCs had detectable FDG uptake on PET by visual analysis, and GSRCs with membranous GLUT-1 expression showed significantly higher FDG uptakes than those with cytoplasmic expression, which suggests that the degree of FDG uptake is affected by GLUT-1 expression in signet ring cells. These results are consistent with those of previous studies [19,24] that examined the relation between FDG uptake and GLUT-1 expression in gastric cancer.…”

Section: Discussionsupporting

confidence: 93%

“…Degree of GLUT-1 expression has previously been shown to be correlated with increased FDG uptake in a [20]. In another study by Yamada et al, noncohesive gastric cancer was found to show significantly lower GLUT-1 expression and FDG uptake than the cohesive type [24]. De Potter et al also reported that only 25% of GSRCs had FDG avidity in a small group study (n=8) [21], which concurs with that found in the Korean population [22].…”

Section: Discussionsupporting

confidence: 71%

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Relation Between Fluorodeoxyglucose Uptake and Glucose Transporter-1 Expression in Gastric Signet Ring Cell Carcinoma

Choi

Song

et al. 2010

Nucl Med Mol Imaging

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Purpose Gastric signet ring cell carcinoma (GSRC) is known to have low fluorodeoxyglucose (FDG) uptake. The aim of the study was to investigate the relation between FDG uptake and glucose transporter (GLUT)-1 expression and clinicopathologic parameters in cases of GSRC. Materials and Methods Forty patients (28 men, mean age 54±12 years) with histologically confirmed GSRC who underwent pre-operative [18 F]FDG PET/CT were enrolled. Maximum standardized uptake values (SUVmax) were compared with clinicopathologic parameters and GLUT-1 expression. Cases were divided based on GLUT-1 expression in tumor tissues into a membranous group (n=17) and a cytoplasmic group (n=23). Results Mean SUVmax was significantly higher in the membranous group than in the cytoplasmic group (6.06± 2.79 vs. 3.67±1.54, P=0.03). Gastric wall invasion, depth of invasion, extent of LN metastasis, overall stage, and tumor size were found to be related to SUVmax. On the other hand, age, sex, and the presence of distant metastasis were not related to SUVmax. Multivariate analysis revealed that membranous GLUT-1 expression and the extent of LN metastasis independently predicted high FDG uptake. Conclusions This study demonstrates that high FDG uptake is mediated by membranous GLUT-1 expression in GSRC.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 71%

Relation Between Fluorodeoxyglucose Uptake and Glucose Transporter-1 Expression in Gastric Signet Ring Cell Carcinoma

Choi

Song

et al. 2010

Nucl Med Mol Imaging

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“…Thus FDG-PET/CT will not replace endoscopy in this patient group and these techniques are complementary. There are a variety of malignant tumours which might be FDG-negative and consequently missed by FDG-PET/CT, such as bronchoalveolar carcinomas, neuroendocrine tumours, low-grade sarcomas or signet ring cell adenocarcinomas [21][22][23]. In our experience the CT part of the PET/ CT study can partially help to overcome this limitation by showing suspicious morphological changes.…”

Section: Discussionmentioning

confidence: 89%

Head and neck squamous cell carcinoma (HNSCC) – detection of synchronous primaries with 18F-FDG-PET/CT

Strobel

Haerle

Stoeckli

et al. 2009

Eur J Nucl Med Mol Imaging

118

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Purpose The aim of the study was to evaluate 18 F-FDG-PET/CT for the detection of synchronous primaries at initial staging of patients with head and neck squamous cell carcinoma (HNSCC). Methods FDG-PET/CT images acquired between March 2001 and October 2007 in 589 consecutive patients (147 women, 442 men; mean age 61.5 years, age range 32-97 years) with proven HNSCC were reviewed for the presence of synchronous primaries. Cytology, histology and/or clinical and imaging follow-up served as reference standard.Results FDG-PET/CT showed 69 suspected synchronous primaries in 62 patients of which 56 were finally confirmed in 44 patients. Of the 56 second cancers, 46 (82%) were found in the aerodigestive tract in the following locations: lung (26, 46%), head and neck (15, 17%), oesophagus (5, 9%). Ten second cancers (18%) were located outside the aerodigestive tract (colon, five; stomach, lymphoma, breast, thymus and kidney, one each). Six patients had three synchronous primaries and three patients had four synchronous cancers. Nine synchronous cancers were not detected by PET/CT (four head and neck, two lung, two oesophageal, one gastric). False-positive PET/CT findings were mainly related to benign FDG uptake in the intestine due to benign or precancerous polyps or physiological FDG uptake in other head and neck regions. Overall the prevalence of synchronous second primaries according to the reference standard was 9.5%, of which 84% were detected with FDG-PET/CT. In 80% of the patients, therapy was changed because of the detection of a synchronous primary. Conclusion FDG-PET/CT detects a considerable number of synchronous primaries (8.0% prevalence) at initial staging of patients with HNSCC. Synchronous cancers were predominantly located in the aerodigestive tract, primarily in the lung, head and neck and oesophagus. Detection of second primaries has an important impact on therapy. PET/ CT should be performed before panendoscopy.

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“…GLUT1 is ubiquitously expressed in almost all cell types, but is frequently overexpressed in malignant tissue, leading to the intracellular accumulation of FDG, which can then be visualized by FDG-PET. In gastric carcinoma, GLUT1 is expressed late in carcinogenesis, and increased amounts are associated with tumor progression and patient survival [7][8][9]. Kawamura et al [7] analyzed GLUT1 protein expression in 617 carcinomas and 50 tubular adenomas of the stomach.…”

Section: Differences Of Histology and Glucose Transporter 1 Expressiomentioning

confidence: 99%

“…Yamada et al [8] evaluated the association between FDG uptake and histopathological type in 40 patients with gastric carcinoma among whom 19 patients (48%) showed detectable FDG uptake. Cohesive carcinomas (papillary adenocarcinoma, tubular adenocarcinoma, and solid-type poorly differentiated adenocarcinoma) were more significantly detectable than non-cohesive carcinomas (signet-ring cell carcinoma and non-solid type poorly differentiated carcinoma) (65 vs. 14%, respectively).…”

Section: Differences Of Histology and Glucose Transporter 1 Expressiomentioning

confidence: 99%

Japanese Gastric Cancer Association Task Force for Research Promotion: clinical utility of 18F-fluoro-2-deoxyglucose positron emission tomography in gastric cancer. A systematic review of the literature

et al. 2011

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Since April 2010, the Japanese Public Health Insurance System has covered the costs incurred for performing 18 F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) imaging for patients with advanced gastric cancer. The aim of this review was to evaluate the clinical impact of PET for patients with gastric cancer. A systematic literature search was performed in PubMed/MEDLINE using the keywords ''gastric cancer'' and ''PET'' to search for relevant articles published from January 2000 to September 2010. The clinical impact of selected articles was assessed by the authors to evaluate the following: (a) tumor staging, (b) diagnosis for recurrent disease, (c) evaluation of treatment response, and (d) screening for gastric cancer. FDG uptake increases in papillary adenocarcinoma, tubular adenocarcinoma, and solid-type poorly differentiated adenocarcinoma. This uptake is also associated with glucose transporter 1 expression. The sensitivity and specificity of FDG-PET for metastatic lymph node detection were 21-40% and 89-100%, respectively. The sensitivity and specificity for distant metastasis detection were 35-74% and 74-99%, respectively. Treatment response can be detectable at an earlier stage by PET than by computed tomography (CT), because FDG uptake by cancer cells decreases according to the treatment response. In summary, although PET has limitations such as frequent false-negative cases in signetring cell carcinoma and non-solid type poorly differentiated carcinoma, it can contribute to the selection of a more appropriate treatment modality by detecting distant metastases and treatment response.

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Evaluation of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography in gastric carcinoma: relation to histological subtypes, depth of tumor invasion, and glucose transporter-1 expression

Cited by 97 publications

References 19 publications

Relation Between Fluorodeoxyglucose Uptake and Glucose Transporter-1 Expression in Gastric Signet Ring Cell Carcinoma

Relation Between Fluorodeoxyglucose Uptake and Glucose Transporter-1 Expression in Gastric Signet Ring Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC) – detection of synchronous primaries with 18F-FDG-PET/CT

Japanese Gastric Cancer Association Task Force for Research Promotion: clinical utility of 18F-fluoro-2-deoxyglucose positron emission tomography in gastric cancer. A systematic review of the literature

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