Evaluation of 25-hydroxy vitamin D3 levels in patients with a fibroid uterus

Srivastava, Pritika; Gupta, Harshita; Singhi, S; Khanduri, Sachin; Rathore, Brijesh

doi:10.1080/01443615.2019.1654986

Cited by 19 publications

(21 citation statements)

References 17 publications

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“…This means that patients with larger UF volumes had lower serum vitamin D levels [111]. Similar conclusions were made by researchers from Italy [113] and India [114,115]. In both studies from India, the patients with UFs had much lower 25(OH)D serum levels as compared with the UF-negative controls [114,115].…”

Section: Vitamin D and Uterine Fibroidssupporting

confidence: 62%

“…Similar conclusions were made by researchers from Italy [113] and India [114,115]. In both studies from India, the patients with UFs had much lower 25(OH)D serum levels as compared with the UF-negative controls [114,115]. In 2018, authors from Turkey found that vitamin D levels were lower in UF-positive patients, but they found no correlation between those levels and the volume, location, and number of UFs [116].…”

Section: Vitamin D and Uterine Fibroidssupporting

confidence: 58%

See 1 more Smart Citation

Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance

Ciebiera

Ali

Zgliczyńska

et al. 2020

IJMS

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Uterine fibroid (UF) is the most common benign tumor pathology of the female reproductive organs. UFs constitute the main reason for a hysterectomy and hospitalization due to gynecological conditions. UFs consist of uterine smooth muscle immersed in a large amount of extracellular matrix (ECM). Genetic studies have demonstrated that UFs are monoclonal tumors originating from the myometrial stem cells that have underwent specific molecular changes to tumor initiating stem cells which proliferate and differentiate later under the influence of steroid hormones. There is growing interest in the role of micronutrients, for example, vitamins, in UFs. This article is a comprehensive review of publications regarding the available data concerning the role of vitamins in the biology and management of UFs. In summary, the results showed that some vitamins are important in the biology and pathophysiology of UFs. For example, vitamins A and D deserve particular attention following studies of their influence on the treatment of UF tumors. Vitamins B3, C, and E have not been as widely studied as the abovementioned vitamins. However, more research could reveal their potential role in UF biology.

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Section: Vitamin D and Uterine Fibroidssupporting

confidence: 62%

Section: Vitamin D and Uterine Fibroidssupporting

confidence: 58%

Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance

Ciebiera

Ali

Zgliczyńska

et al. 2020

IJMS

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“…In a case-control study performed on 90 women, the mean concentration of 25-(OH) D3 was significantly lower in women with UL compared with the controls (p < 0.001). In the latter study, the UL size increased proportionately with the decrease in 25-(OH) D3 levels (p = 0.014) [13]. In another study on 124 women (n = 56 UL and n = 68 healthy control), the mean level of 25-(OH) D3 was also significantly lower among those with UL; however, vitamin D level was not correlated with the size or volume of UL [14].…”

Section: Introductionmentioning

confidence: 89%

“…Of these, 68 full-text articles were retrieved to be assessed for eligibility based on the study's inclusion criteria. Finally, 9 articles (4 case-control [21][22][23][24] and 4 cross-sectional [13,14,25,26] and 1 retrospective cohort study [27] were selected for the current meta-analysis. Figure 1 illustrates the steps of the study identification and selection process in this review.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…The nine included articles comprised 1730 participants (ranging from 64 to 432), numbering 835 and 895 in case and control groups, respectively. The included studies were published between 2013 [21,25] and 2019 [13]; three studies were conducted in India [13,23,26], and one each in Italy [21], Egypt [25], Poland [27], Congo [22], Iraq [24], and Turkey [14]. The characteristics of the nine included articles with more details are shown in Table 1.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Correlation of low serum vitamin-D with uterine leiomyoma: a systematic review and meta-analysis

Mohammadi

Tabrizi

Hessami

et al. 2020

Reprod Biol Endocrinol

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Background: There is a growing body of evidence on low serum vitamin-D levels and the risk of uterine leiomyomas (UL). Therefore, this systematic review and meta-analysis was conducted to investigate the association between serum vitamin D levels and UL occurrence. Methods: Searches were systematically conducted of the electronic databases PubMed, Scopus, EMBASE, Web of Science (ISI), Cochrane library, Ovid, and Google Scholar to identify relevant studies from inception until February 6, 2020. Heterogeneity across the included studies was examined using Cochran's Q and I-square (I 2). Data was pooled using random effects modeling and expressed as standardized mean differences (SMDs). Results: Nine eligible studies with a total of 1730 participants (835 patients with UL and 895 controls) were included in the current meta-analysis. Pooled results with random effects modeling indicated that serum vitamin D levels were significantly lower in patients with UL than in the control group (n = 9, SMD = − 0.67; 95% CI, − 0.98, − 0.35, p < 0.001; I 2 = 89.3%, p < 0.001). Based on the findings of subgroup analyses, it was found that the SMD values across the included studies from Asia (n = 4, SMD = − 1.20; 95% CI, − 1.45, − 0.96, p < 0.001; I 2 = 30.6%, p = 0.229) were lower than those from Europe (n = 3, SMD = − 0.34; 95% CI, − 0.49, − 0.18, p < 0.001; I 2 = 0.0%, p = 0.602) and Africa (n = 2, SMD = − 0.13; 95% CI, − 0.29, 0.04, p = 0.128; I 2 = 0.0%, p = 0.417), although the difference was not significant in Africa. Publication year was also found to be a potential contributor's variable in the pooled SMD using the meta-regression method (t = − 3.00, p = 0.02). Conclusions: To the best of our knowledge, the current meta-analysis showed for the first time that serum vitamin D levels were significantly lower in women with UL in selected populations.

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The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids

et al. 2020

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Uterine fibroids (UFs) are benign tumors originating from smooth muscle cells and are considered a common pathology that affects numerous women which is a notable socio-economic problem. Several UF risk factors have been identified including black race, obesity, and vitamin D deficiency. Vitamin D is steroid compound with pleiotropic effects on the human body. Vitamin D deficiency is a major public health concern worldwide. Several studies have shown that the majority of UF patients experienced hypovitaminosis D. In addition, sufficient vitamin D serum levels are associated with the reduced risk of UFs. In this review, we present available data highlighting the importance of measuring vitamin D serum levels in women with UFs and women at a high risk for UF development. We proposed a preliminary clinical instruction of 25-hydroxyvitamin D measurements and vitamin D supplementation for clinicians who are involved in the treatment of patients with UFs. Achieving sufficient serum levels of vitamin D might be of interest in patients with UFs. Screening, supplementation, treatment guidelines, and public health strategies for vitamin D deficiency in women with UFs as well as women at a high risk of UF development might be of potential importance as well.

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Evaluation of 25-hydroxy vitamin D3 levels in patients with a fibroid uterus

Cited by 19 publications

References 17 publications

Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance

Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance

Correlation of low serum vitamin-D with uterine leiomyoma: a systematic review and meta-analysis

The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids

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