Evaluation of 5-HTTLPR (insertion/deletion) and BDNF (rs6265) genetic variations in the Slovakian individuals suffering from affective disorders

Bednarova, Aneta; Čižmáriková, Martina; Habalová, Viera; Jarcusková, D

doi:10.4149/gpb_2021025

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…Among other BDNF gene polymorphisms, rs962369 was found to have a strong association with suicidal ideation during antidepressant treatment [ 15 ] as well as with suicide completion [ 16 ]. We have previously demonstrated a significant association between BDNF (rs6265) and highly polygenic region 5-HTTLPR of the SLC6A4 (a gene-encoding serotonin transporter) genetic variations in patients suffering from affective disorders [ 17 ]. The latter genetic variant has also been studied with suicide.…”

Section: Introductionmentioning

confidence: 99%

Association of HTTLPR, BDNF, and FTO Genetic Variants with Completed Suicide in Slovakia

Bednarova

Habalová

Iannaccone

et al. 2023

JPM

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Since suicide and suicidal behavior are considered highly heritable phenotypes, the identification of genetic markers that can predict suicide risk is a clinically important topic. Several genes studied for possible associations between genetic polymorphisms and suicidal behaviors had mostly inconsistent and contradictory findings. The aim of this case-control study was to evaluate the associations between completed suicide and polymorphisms in genes BDNF (rs6265, rs962369), SLC6A4 (5-HTTLPR), and FTO (rs9939609) in relation to sex and BMI. We genotyped 119 completed suicide victims and 137 control subjects that were age, sex, and ethnicity matched. A significant association with completed suicide was found for BDNF rs962369. This variant could play a role in completed suicide, as individuals with the CC genotype were more often found among suicides than in control subjects. After sex stratification, the association remained significant only in males. A nominally significant association between the gene variant and BMI was observed for BDNF rs962369 under the overdominant model. Heterozygotes with the TC genotype showed a lower average BMI than homozygotes with TT or CC genotypes. FTO polymorphism (rs9939609) did not affect BMI in the group of Slovak suicide completers, but our findings follow an inverse association between BMI and completed suicide.

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Section: Introductionmentioning

confidence: 99%

Association of HTTLPR, BDNF, and FTO Genetic Variants with Completed Suicide in Slovakia

Bednarova

Habalová

Iannaccone

et al. 2023

JPM

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Serotonin transporter 5-HTTLPR polymorphism and escitalopram treatment response in patients with major depressive disorder

Jarčušková,

Tkáč,

Hlaváčová

et al. 2024

BMC Psychiatry

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Background There is no doubt that genetic factors have the potential to predict the therapeutic outcomes of antidepressants in patients with major depressive disorder (MDD). This study investigated the association between genetic variants involved in serotonin signaling and brain-derived neurotrophic factor (BDNF) with the response to escitalopram treatment in patients with MDD. We focused on examining the influence of 5-HTTLPR (ins/del), HTR2A rs9316233, BDNF rs962369, CYP2C19 and CYP2D6 on the clinical response to escitalopram. Methods The patients were recruited from outpatient psychiatric clinics in Košice between 2020 and 2022. Patients received escitalopram for 12 weeks at a fixed dose of 10 mg daily. Clinical assessment was done at baseline and after 4, 8, and 12 weeks using the 21-item Hamilton Depression Rating Scale (HAMD-21). Results At the end of week 12, 57 (65%) patients were defined as responders to escitalopram treatment, while 31 (35%) patients were non-responders. Genotyping revealed that carriers of the short allele (S) of 5-HTTLPR exhibit a significantly lower therapeutic response to escitalopram measured by HAMD-21 than the long allele (L) carriers ( p = 0.01). Adjusting for CYP2C19 and CYP2D6 metabolizer genotypes did not modify the observed relationship between 5-HTTLPR and treatment response. No significant associations were found for HTR2A rs9316233 or BDNF rs962369 variants and the treatment response. Conclusions These findings underscore the utility of 5-HTTLPR genotyping in guiding escitalopram therapy for MDD patients. Further research with larger cohorts is warranted to validate these results and elucidate additional genetic determinants of antidepressant efficacy.

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Behavioral tests for evaluating the characteristics of brain diseases in rodent models: Optimal choices for improved outcomes (Review)

Huang¹,

Xiao²,

Orecchioni³

et al. 2022

Mol Med Rep

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Behavioral assessment is the dominant approach for evaluating whether animal models of brain diseases can successfully mimic the clinical characteristics of diseases. at present, most research regarding brain diseases involves the use of rodent models. While studies have reported numerous methods of behavioral assessments in rodent models of brain diseases, each with different principles, procedures, and assessment criteria, only few reviews have focused on characterizing and differentiating these methods based on applications for which they are most appropriate. Therefore, in the present review, the representative behavioral tests in rodent models of brain diseases were compared and differentiated, aiming to provide convenience for researchers in selecting the optimal methods for their studies. Contents1. introduction 2. Principles, procedures, assessment, and application of different behavioral tests 3. discussion 4. conclusion

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Evaluation of 5-HTTLPR (insertion/deletion) and BDNF (rs6265) genetic variations in the Slovakian individuals suffering from affective disorders

Cited by 3 publications

References 45 publications

Association of HTTLPR, BDNF, and FTO Genetic Variants with Completed Suicide in Slovakia

Association of HTTLPR, BDNF, and FTO Genetic Variants with Completed Suicide in Slovakia

Serotonin transporter 5-HTTLPR polymorphism and escitalopram treatment response in patients with major depressive disorder

Behavioral tests for evaluating the characteristics of brain diseases in rodent models: Optimal choices for improved outcomes (Review)

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