Evaluation of a biodegradable novel periosteal distractor

Zakaria, Osama; Kon, Kazuhiro; Kasugai, Shohei

doi:10.1002/jbm.b.31944

Cited by 24 publications

(34 citation statements)

References 25 publications

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“…There was no control group to compare the results; however, in our previous studies, 11,40 we used devices to elevate the periosteum and overlying soft tissue without any secluding membrane in the same calvarial rabbit model.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, we and others have been reported that gradual periosteum elevation creating a space over bone surface results in new bone formation in this space. 11–16 These studies clearly suggest that elevating periosteum and providing space over bone surface elicit new bone formation. However, the invasion of the created space with highly competitive nonosteogenic soft tissue and poor quality of the newly formed bone are the main drawbacks of this technique.…”

Section: Introductionmentioning

confidence: 91%

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A novel osteogenesis technique: The expansible guided bone regeneration

2012

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Guided bone regeneration is a unique osteogenesis technique that requires a barrier membrane under periosteum to create space for bone regeneration. However, creating sizeable spaces is clinically not commonly feasible. A titanium plate and a thin silicone membrane were surgically layered on each calvaria of eight rabbits. Then, the periphery of the silicone membrane was fixed by a plastic ring to the underlying bone using titanium micro screws. After 1 week, a 5-mm-length titanium screw was used to elevate the titanium plate, which in turn elevated the silicone membrane together with overlying soft tissue in a rate of 1 mm/day for 5 days to create a secluded space. Animals were killed at 2 months (n = 4, group 1) and 4 months (n = 4, group 2) after the elevation. Histological and microradiographical analyses demonstrated creation of an amount of de novo bone formation (68.2 ± 22 mm3 in group 1 and 70.3 ± 14 mm3 in group 2) in the sizeable created spaces (207.1 ± 31 mm3 in group 1 and 202 ± 21 mm3 in group 2) without exposure of the device. This novel osteogenesis technique, “expansible guided bone regeneration,” created a substantial in vivo incubator without applying growth factors or osteoprogenitor cells. Creating a growing space over the secluded surface allowed the development of normal biological healing process occurring on the bone surface into a regenerative process, generating bone outside the genetically determined skeletal bone. This technique is a new tissue engineering approach stimulating endogenous tissue repair without applying cells or factors exogenously.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

A novel osteogenesis technique: The expansible guided bone regeneration

2012

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“…In another experiment, the graft which was implanted in the distracted area between the alveolar bone and β -TCP block could stably exist [45]. Zakaria et al [27] then tried to use biodegradable poly-L-lactide/hydroxyapatite (PLLA/HA) mesh (Figure 1(d)) to replace the titanium mesh for distracting periosteum. Recently, Dziewiecki et al [37] compared nondegradable titanium to degradable devices (poly-DL-lactide and polyglycolic acid) in PDO; they also proved that degradable devices could produce new bone and there were no significant differences in the amount of newly formed bone between titanium and degradable materials.…”

Section: The Designs and Materials Of Distraction Devicesmentioning

confidence: 99%

“…However, Saulacic et al [36] believed that the high speed of distraction might be beneficial to periosteal osteogenesis, although it was easy to cause the disruption of wound and exposure of the device. Zakaria et al [27, 28] designed a new type of device, by means of the inclined structure; this device could be used to study the effect of different distraction rates at the same time. The result suggested that the optimal speed of distraction should be lower than 0.33 mm/d.…”

Section: Effect Of Distraction Strategies On the Formation Of New mentioning

confidence: 99%

Periosteal Distraction Osteogenesis: An Effective Method for Bone Regeneration

Zhao

Wang

Han

2016

BioMed Research International

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The treatment of bone defects is challenging and controversial. As a new technology, periosteal distraction osteogenesis (PDO) uses the osteogenicity of periosteum, which creates an artificial space between the bone surface and periosteum to generate new bone by gradually expanding the periosteum with no need for corticotomy. Using the newly formed bone of PDO to treat bone defects is effective, which can not only avoid the occurrence of immune-related complications, but also solve the problem of insufficient donor. This review elucidates the availability of PDO in the aspects of mechanisms, devices, strategies, and measures. Moreover, we also focus on the future prospects of PDO and hope that PDO will be applied to the clinical treatment of bone defects in the future.

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“…Analyzing the molecular events leading to successful DO has important clinical implications, since this is a fundamental step toward the evolution of targeted therapeutic interventions designed to accelerate osseous regeneration during distraction. Current research that is focused on the development of minimally invasive approaches; stem cells; biodegradable multiplanar distraction devices (Cohen & Holmes, 2001;Yamauchi, Mitsugi & Takahashi, 2007;Zakaria, Kon & Kasugai, 2012), should aim at decreasing the distraction and consolidation times, reducing complications, and optimizing patient outcomes.…”

Section: The Futurementioning

confidence: 99%

Distraction Osteogenesis: Evolution and Contemporary Applications in Orthodontics

Cherackal¹,

Thomas²

2014

DENT

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Orthodontic tooth movement is brought about by the biomechanical utilization of the physiological mechanisms for bone remodeling in order to achieve optimal occlusion and thereby maximize the esthetic outcome. Distraction osteogenesis is a biomechanical process of bone tissue formation, where the distraction forces which act between the bone segments effect the biological potential of the bone. Though initially used in long bones, through the past years the technique has undergone significant advancements and innovations, that it has had increasing applications in the facial skeleton. The gradual evolution of compact internal appliances has lately led to the use of this concept in the field of orthodontics for moving tooth segments rapidly for an accelerated treatment outcome, and for novel modalities in the treatment of ankylosed teeth. This article is presented under the light of current literature to review the history, evolution and role of distraction in contemporary orthodontics.

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Evaluation of a biodegradable novel periosteal distractor

Abstract: The new device is slim, biodegradable and the procedure is simple. Thus, periosteal distraction with this device is potential for vertical and horizontal ridge augmentation in oral cavity.

Cited by 24 publications

References 25 publications

A novel osteogenesis technique: The expansible guided bone regeneration

A novel osteogenesis technique: The expansible guided bone regeneration

Periosteal Distraction Osteogenesis: An Effective Method for Bone Regeneration

Distraction Osteogenesis: Evolution and Contemporary Applications in Orthodontics

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