Evaluation of a combination chemotherapy protocol including lomustine and doxorubicin in canine histiocytic sarcoma

Cannon, Claire M.; Borgatti, Antonella; Henson, Michael; Husbands, Brian D

doi:10.1111/jsap.12354

Cited by 42 publications

(59 citation statements)

References 18 publications

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“…In dogs the metastatic rate of HS is reported to be around 90% (Skorupski and others 2007, Cannon and others 2015). HS has a familial relationship in bernese mountain dogs and rottweilers (Tsai and others 2012).…”

Section: Discussionmentioning

confidence: 99%

“…It has also been reported to have some efficacy as a maintenance and induction agent for lymphoma in cats although its efficacy as an induction agent for mediastinal lymphoma is still questionable (Moore and others 1996, Peaston and Maddison 1999). Doxorubicin has also been reported to have some efficacy against HS (Cannon and others 2015). Doxorubicin was therefore considered the best first line drug to use while waiting for results of immunohistochemistry.…”

Section: Discussionmentioning

confidence: 99%

“…Given the cost and difficulty of obtaining immunotherapy, lomustine was considered to be a good treatment option in this case. Since the case presented a study using combination therapy of doxorubicin and CCNU in dogs with HS reported overall response rate of 58%, with a median time to tumour progression of 185 days has been published (Cannon and others 2015). …”

Section: Discussionmentioning

confidence: 99%

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Mediastinal histiocytic sarcoma with abdominal metastasis in a Somali cat

Bisson¹,

Steen²,

Hawkins³

et al. 2017

Vet Record Case Reports

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A nine–year-old female neutered Somali cat presented with a one-month history of weight loss and inappetance. Thoracic radiographs revealed an extensive cranial mediastinal mass, and fine needle aspirate cytology and core needle biopsies were initially suggestive of a thymoma. The mass was excised via a mid-ine sternotomy and partial pericardectomy. Clinical signs recurred four weeks postsurgery and investigations revealed recurrence of a mediastinal mass, pleural effusion and an additional small mass cranial to the right kidney. Histopathological examination and immunohistochemistry of the previously resected mass prompted a revised diagnosis of histiocytic sarcoma (HS) with abdominal metastasis. The cat was treated with doxorubicin and lomustine but did not respond well and was euthanased two months later. HS is an uncommon neoplasm in cats with only two cases of mediastinal involvement reported in the literature. This case underlines the importance of immunohistochemistry in the evaluation of mediastinal masses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Mediastinal histiocytic sarcoma with abdominal metastasis in a Somali cat

Bisson¹,

Steen²,

Hawkins³

et al. 2017

Vet Record Case Reports

View full text Add to dashboard Cite

show abstract

“…Additional modifications can be made as necessary in patients in which toxicity is a problem so that quality of life is maintained during treatment. Chemotherapy can be used before (neoadjunctive) or after (adjunctive) surgery for solid tumours and occasionally as a sole agent in the palliative setting (Page and others 1993, Chun and others 1997, Bacon and others 2008, Bailey and others 2008, Bulakowski and others 2008, Grant and others 2008, Kisseberth and others 2008, Rassnick and others 2008, Cooper and others 2009, Dominguez and others 2009, Lori and others 2010, Arnold and others 2011, Fidel and others 2011, Bray and Polton 2014, Selmic and others 2014, Cannon and others 2015, Culp and others 2015, Marconato and others 2015) (Table 5). Intracavitatory chemotherapy can be useful in some patients with neoplastic pleural effusion (Charney and others 2005); permanent pleural ports are well tolerated and facilitate delivery as well as allowing drainage of the effusion.…”

Section: Chemotherapymentioning

confidence: 99%

Palliative care in small animal oncology

Mason¹

2016

In Practice

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Cancer is a common diagnosis in companion animals and, increasingly, clients choose to pursue treatment for their pets. Veterinary oncology is a rapidly growing field and diagnostic and treatment options for animals with cancer are constantly improving and becoming more widely available. Treatment outcomes can be good, but in many cases definitive treatment is not an option and palliative treatment is necessary. This article explores the palliative care of dogs and cats that have been diagnosed with cancer and summarises the various treatment options, with a particular focus on quality of life and the role of communication in the decision-making process.

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“…A quimioterapia é indicada como um dos tratamentos principais, tanto para o sarcoma histiocítico localizado, metastático ou não, quanto para o disseminado. A quimioterapia pode ser também utilizada após a realização da retirada cirúrgica ou de radioterapia para as neoplasias localizadas, o que indica um aumento na sobrevida do animal (CANNON et al, 2015;MARIANNI et al, 2015).…”

Section: Introductionunclassified

Sarcoma Histiocítico Com Múltiplas Localizações Em Um Cão

Oliveira¹,

Modesto²,

Dias³

et al. 2018

Enci Bio

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RESUMOAs doenças proliferativas histiocíticas são desordens conhecidas no cão e que possuem inúmeras origens, muitas ainda não completamente elucidadas. O complexo sarcoma histiocítico pode ser dividido em três principais tipos: sarcoma histiocítico localizado, sarcoma histiocítico disseminado e sarcoma histiocítico hemofagocítico. O objetivo desse trabalho foi relatar um caso de sarcoma histiocítico disseminado acometendo múltiplas localizações em um Rotweiler. O animal foi atendido pelo Hospital Veterinário da Universidade Federal de Uberlândia (HV-UFU) com a queixa de um aumento de volume em membro posterior esquerdo e presença de uma massa em placa na região de glândulas mamárias torácica caudal à inguinal esquerda. Foi realizada a punção aspirativa por agulha fina da massa e obteve-se o diagnóstico de sarcoma histiocítico. Após dois dias de piora clínica o animal foi eutanasiado e então o Laboratório de Patologia Animal do HV-UFU realizou o exame de necropsia. Ao realizar o exame foi observada linfadenomegalia em linfonodos axilar e inguinal esquerdos, e a presença de uma massa aderida à parede dorsal de cavidade abdominal. Os órgãos alterados foram coletados e após realização de exame histopatológico foi confirmado o diagnóstico de sarcoma histiocítico com metástase para linfonodo axilar e inguinal esquerdos. PALAVRAS-CHAVE: citopatológico, complexo sarcoma histiocítico, neoplasma, metástase.

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Evaluation of a combination chemotherapy protocol including lomustine and doxorubicin in canine histiocytic sarcoma

Abstract: The protocol appeared well-tolerated, had some efficacy against canine histiocytic sarcoma in the study population and could be considered as an alternative to single-agent protocols; prospective comparison may be warranted.

Cited by 42 publications

References 18 publications

Mediastinal histiocytic sarcoma with abdominal metastasis in a Somali cat

Mediastinal histiocytic sarcoma with abdominal metastasis in a Somali cat

Palliative care in small animal oncology

Sarcoma Histiocítico Com Múltiplas Localizações Em Um Cão

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