Evaluation of a dual electrospray ionization/atmospheric pressure chemical ionization source at low flow rates (∼50 <i>µ</i>L/min) for the analysis of both highly and weakly polar compounds

Siegel, Marshall M.; Tabei, Keiko; Lambert, Frank; Candela, Leonard; Zoltan, Bart

doi:10.1016/s1044-0305(98)00085-3

Cited by 42 publications

(36 citation statements)

References 6 publications

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“…Several groups have been hybridizing available technologies for better coverage of increasingly diverse target compounds by LC-MS, for example, a combination of ESI/APCI [75,76], APPI with APCI or ESI [77,78], ESI with APLI [79] and APCI with APLI [33].…”

Section: Multipurpose Ion Sourcesmentioning

confidence: 99%

Gas chromatography coupled to atmospheric pressure ionization mass spectrometry (GC-API-MS): Review

Gan

Bronja

et al. 2015

Analytica Chimica Acta

138

101

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Section: Multipurpose Ion Sourcesmentioning

confidence: 99%

Gas chromatography coupled to atmospheric pressure ionization mass spectrometry (GC-API-MS): Review

Gan

Bronja

et al. 2015

Analytica Chimica Acta

138

101

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“…Other authors have previously presented a capillary electrophoresis-MS coupling with a miniaturized APCI source by modifying a commercial source (Tanaka, Otsuka, & Terabe, 2003). Another trend in MS is multimode ionization sources (Siegel et al, 1998;Gallagher et al, 2003;Syage et al, 2004;Schiewek et al, 2008); for example, APCI/APPI (ESI/APPI and ESI/APCI are also commercialized). Three modes of operation are available for the APCI/APPI dual source: APPI only, APCI only, and APPI/APCI simultaneous operation (Syage et al, 2004).…”

Section: Factors That Influence the Performance Of Apcimentioning

confidence: 99%

APCI/APPI for synthetic polymer analysis

Terrier

Desmazières

Tortajada

et al. 2011

Mass Spectrometry Reviews

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Modern mass spectrometry of synthetic polymers involves soft ionization techniques. Whereas matrix-assisted laser desorption/ionization (MALDI) and electrospray (ESI) are employed routinely, atmospheric pressure chemical ionization (APCI) and more recently atmospheric pressure photoionization (APPI) are used to a lesser extent. However, these latter ionization methods coupled to liquid-phase separation techniques create new opportunities for the characterization of polymers, especially for low molecular weight compounds or for the polymers that are poorly ionizable by the usual methods. After a part devoted to the description of classical MS methods employed for polymer analysis (MALDI, ESI, and their use with chromatography), APCI and APPI techniques will be described, discussed, and selected examples will present the interest of these ionization sources (or interfaces for LC/MS) in the field of polymer analysis.

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“…Siegel et al (39) reported a combination APCI/ESI source designed for low flow rates, which allowed operation in several modes. ESI only, APCI only, mixed ESI-APCI (in which both ESI and APCI operated simultaneously), and alternating ESI and APCI modes were available.…”

Section: Other Fa and Tag Applicationsmentioning

confidence: 99%

Atmospheric pressure chemical ionization mass spectrometry for analysis of lipids

Byrdwell

2001

Lipids

247

134

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Atmospheric pressure chemical ionization (APCI) mass spectrometry (MS) has proven to be a very valuable technique for analysis of lipids from a variety of classes. This instrumental method readily produces useful ions with gentle fragmentation from large neutral molecules such as triacylglycerols and carotenoids, which are often difficult to analyze using other techniques. Molecules that are easily ionized, such as phospholipids, produce molecular ions and diagnostically useful fragment ions that are complementary to those produced by methods such as electrospray ionization MS with collision-induced dissociation. The simplicity and versatility of APCI-MS make it an ideal tool for use in solving hitherto very difficult analytical problems.

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Evaluation of a dual electrospray ionization/atmospheric pressure chemical ionization source at low flow rates (∼50 µL/min) for the analysis of both highly and weakly polar compounds

Cited by 42 publications

References 6 publications

Gas chromatography coupled to atmospheric pressure ionization mass spectrometry (GC-API-MS): Review

Gas chromatography coupled to atmospheric pressure ionization mass spectrometry (GC-API-MS): Review

APCI/APPI for synthetic polymer analysis

Atmospheric pressure chemical ionization mass spectrometry for analysis of lipids

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