Evaluation of a human gut-associated phage and gut dominant microbial phyla in the metabolic syndrome

Baghi, Hossein Bannazadeh; Naghili, Behrooz; Shanehbandi, Dariush; Leylabadlo, Hamed Ebrahimzadeh

doi:10.1016/j.clnesp.2022.06.009

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…In studies conducted by Gallardo‑Becerra et al [ 154 ] and Haro et al [ 155 ], in children and adults respectively, a higher abundance of Firmicutes and a lower abundance of Bacteroidetes were found in patients with MetS. These differences were statistically significant when obese patients with MetS were compared with normal-weight subjects; however, obese patients without MetS also showed an increase in the F/B ratio [ 154 , 156 ]. Given that obesity plays a central role in the development of MetS, it’s not surprising that dysbiosis goes in the same direction.…”

Section: Modifiable Risk Factors Of Mets In Childhood and Adolescencementioning

confidence: 99%

“…Metabolic syndrome has been associated with a higher Firmicutes/Bacteroidetes ratio (F/B) [ 154 – 156 ]. In studies conducted by Gallardo‑Becerra et al [ 154 ] and Haro et al [ 155 ], in children and adults respectively, a higher abundance of Firmicutes and a lower abundance of Bacteroidetes were found in patients with MetS.…”

Section: Modifiable Risk Factors Of Mets In Childhood and Adolescencementioning

confidence: 99%

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Mechanisms and risk factors of metabolic syndrome in children and adolescents

Codazzi,

Frontino,

Galimberti

et al. 2023

Endocrine

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Metabolic syndrome (MetS) is a complex disorder characterized by abdominal obesity, elevated blood pressure, hyperlipidemia, and elevated fasting blood glucose levels. The diagnostic criteria for MetS in adults are well-established, but there is currently no consensus on the definition in children and adolescents. The etiology of MetS is believed to involve a complex interplay between genetic predisposition and environmental factors. While genetic predisposition explains only a small part of MetS pathogenesis, modifiable environmental risk factors play a significant role. Factors such as maternal weight during pregnancy, children’s lifestyle, sedentariness, high-fat diet, fructose and branched-chain amino acid consumption, vitamin D deficiency, and sleep disturbances contribute to the development of MetS. Early identification and treatment of MetS in children and adolescents is crucial to prevent the development of chronic diseases later in life. In this review we discuss the latest research on factors contributing to the pathogenesis of MetS in children, focusing on non-modifiable and modifiable risk factors, including genetics, dysbiosis and chronic low-grade inflammation.

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Section: Modifiable Risk Factors Of Mets In Childhood and Adolescencementioning

confidence: 99%

Section: Modifiable Risk Factors Of Mets In Childhood and Adolescencementioning

confidence: 99%

Mechanisms and risk factors of metabolic syndrome in children and adolescents

Codazzi,

Frontino,

Galimberti

et al. 2023

Endocrine

View full text Add to dashboard Cite

show abstract

“…The gastrointestinal tractʹs inflammatory burden, including ulcerative and Crohn's disease, can be managed through microbiota modulation, biofilm disruption, and the control of proinflammatory bacterial flare-ups [120]. Dysbiosis interrupts the bacterial population with a consequential impact on metabolic processes, including glucose and fatty acid metabolism, adiposity leading to obesity, non-alcoholic fatty liver, and heart diseases [151]. Bacteriophage-aided gastrointestinal tract microbiota optimization is instrumental for efficient metabolic conditions.…”

Section: Roles In Preventing and Treating Specific Gut Microbiota-rel...mentioning

confidence: 99%

The Role of Bacteriophages in the Gut Microbiota: Implications for Human Health

Emencheta,

Olovo,

Eze

et al. 2023

Pharmaceutics

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Bacteriophages (phages) are nano-sized viruses characterized by their inherent ability to live off bacteria. They utilize diverse mechanisms to absorb and gain entry into the bacterial cell wall via the release of viral genetic material, which uses the replication mechanisms of the host bacteria to produce and release daughter progeny virions that attack the surrounding host cells. They possess specific characteristics, including specificity for particular or closely related bacterial species. They have many applications, including as potential alternatives to antibiotics against multi-resistant bacterial pathogens and as control agents in bacteria-contaminated environments. They are ubiquitously abundant in nature and have diverse biota, including in the gut. Gut microbiota describes the community and interactions of microorganisms within the intestine. As with bacteria, parasitic bacteriophages constantly interact with the host bacterial cells within the gut system and have obvious implications for human health. However, it is imperative to understand these interactions as they open up possible applicable techniques to control gut-implicated bacterial diseases. Thus, this review aims to explore the interactions of bacteriophages with bacterial communities in the gut and their current and potential impacts on human health.

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