Evaluation of a liquid electron ionization liquid chromatography–mass spectrometry interface

Termopoli, Veronica; Famiglini, Giorgio; Palma, Pierangela; Piergiovanni, Maurizio; Rocío‐Bautista, Priscilla; Ottaviani, M. Francesca; Saeed, Mansoor; Perry, Simon J.

doi:10.1016/j.chroma.2019.01.034

Cited by 38 publications

(47 citation statements)

References 49 publications

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“…The membrane rejects ionized matrix components and particulate matter while allowing hydrophobic analytes to permeate through and dissolve into a flowing acceptor phase solvent (Krogh and Gill, 2018). The acceptor phase (typically methanol), containing the membrane-permeable fraction of the sample, is then infused into an appropriate ionization source, often electrospray or liquid electron ionization (Termopoli et al, 2019a;Vandergrift et al, 2020), to provide real-time results, which can be employed to provide both qualitative and quantitative data. This method has been applied to a wide range of analytes and sample matrices, including pharmaceuticals in wastewater (Duncan et al, 2016b), fatty acids in salmon tissue (Borden et al, 2019), NAs in water (Duncan et al, 2016a) and constructed wetlands (Duncan et al, 2020), PAHs in water and soil samples (Termopoli et al, 2016;Vandergrift et al, 2019), and the determination of acid dissociation constants of trace organic contaminants in aqueous solutions (Feehan et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Direct mass spectrometric analysis of naphthenic acids and polycyclic aromatic hydrocarbons in waters impacted by diluted bitumen and conventional crude oil

Monaghan

Richards

Vandergrift

et al. 2021

Science of The Total Environment

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Highlights: 1. Constructed waters impacted by diluted bitumen (DB) and conventional crude (CC) across salinity and pH range. 2. Online membrane sampling coupled to direct mass spectrometry measures trace contaminants in water. 3. DB imparts higher concentrations of naphthenic acids with both oils exhibiting marked pH dependence. 4. CC imparts higher concentration of naphthalenes with no observable pH or salinity effects. 5. Mass spectral data is used to discriminate water impacted by DB and CC oils.

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Section: Introductionmentioning

confidence: 99%

Direct mass spectrometric analysis of naphthenic acids and polycyclic aromatic hydrocarbons in waters impacted by diluted bitumen and conventional crude oil

Monaghan

Richards

Vandergrift

et al. 2021

Science of The Total Environment

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“…Recently, the same research group reported some changes in the proposed LEI interface including a modified geometry of the vaporization area. These modifications allow a better control of the heat distribution and an efficient liquid-to-gas conversion 31 .…”

Section: Ionizationmentioning

confidence: 99%

Current developments in LC-MS for pharmaceutical analysis

Beccaria

Cabooter

2020

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“…17,18 Cappiello and coworkers presented several generations and versions of this type of instrument and utilized it in a range of applications. [19][20][21][22][23][24] This technology was also used by Gill and coworkers. 24 Recently, Mondello and coworkers also had begun working on EI-LC-MS applications.…”

Section: Introductionmentioning

confidence: 99%

“…Later, the idea of EI‐LC‐MS was developed by several groups 17,18 . Cappiello and coworkers presented several generations and versions of this type of instrument and utilized it in a range of applications 19–24 . This technology was also used by Gill and coworkers 24 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of impurities in pharmaceuticals by LC‐MS with cold electron ionization

2020

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Pharmaceuticals require careful and precise determination of their impurities that might harm the user upon consumption. Although today, the most common technique for impurities identification is liquid chromatography-mass spectrometry (LC-MS/MS), it has several downsides due to the nature of the ionization method. Also, the analyses in many cases are targeted thus despite being present, some of the compounds will not be revealed. In this paper, we propose and show a new method for untargeted analysis and identification of impurities in active pharmaceutical ingredients (APIs). The instrument used for these analyses is a novel electron ionization (EI) LC-MS with supersonic molecular beams (SMB). The EI-LC-MS-SMB was implemented for analyses of several drug samples spiked with an impurity. The instrument provides EI mass spectra with enhanced molecular ions, named Cold EI, which increases the identification probabilities when the compound is identified with the aid of an EI library like National Institute of Standards and Technology (NIST). We analyzed ibuprofen and its impurities, and both the API and the expected impurity were identified with names and structures by the NIST library. Moreover, other unexpected impurities were found and identified proving the ability of the EI-LC-MS-SMB system for truly untargeted analysis. The results show a broad dynamic range of four orders of magnitude at the same run with a signal-to-noise ratio of over 10 000 for the API and almost uniform response.

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Evaluation of a liquid electron ionization liquid chromatography–mass spectrometry interface

Cited by 38 publications

References 49 publications

Direct mass spectrometric analysis of naphthenic acids and polycyclic aromatic hydrocarbons in waters impacted by diluted bitumen and conventional crude oil

Direct mass spectrometric analysis of naphthenic acids and polycyclic aromatic hydrocarbons in waters impacted by diluted bitumen and conventional crude oil

Current developments in LC-MS for pharmaceutical analysis

Analysis of impurities in pharmaceuticals by LC‐MS with cold electron ionization

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