Evaluation of a new herbal formulation (Viabet®) efficacy in patients with type 2 diabetes as an adjuvant to metformin: A randomized, triple-blind, placebo-controlled clinical trial

Effect of steviol glycosides as natural sweeteners on glucose metabolism in adult participants

“…19,20,24,28,29 Similarly, the high dosage of SGs (>250 mg d −1 ) did not show a significant reduction in FBG. Results from post hoc subgroup analyses revealed that there were no significant associations between SGs and FBG in adults with hypertension [30][31][32] and normal weight, 24,30,32,34 and in studies using capsules 19,20,24,[29][30][31][32][33] and with a follow-up duration >3 months. 20,[30][31][32] Consistent findings within main results were observed in all the subgroup analyses for HbA1c, insulin and HOMA-IR measurements.…”

“…[30][31][32] The type of SG consumption included capsules, 19,20,24,[30][31][32][33] drinks, 23,28 drops, 27 and sugar and stevia blends, 34 with the frequency of SG intake ranging from daily 19,23,24,31,34 to thrice a day. [28][29][30]32 The daily doses of SGs varied from 12 mg 28 to 3 g. 19 There were three studies that did not use blinding 19,27,34 and two trials with a high risk of selective reporting, 19,23 respectively. Only one study was rated as having low risk of bias (eFig.…”

“…No significant effect of SGs on FBG was found in participants aged >50 years 19,20,24,[28][29][30]32 or with DM at baseline (Table 2). 19,20,24,28,29 Similarly, the high dosage of SGs (>250 mg d −1 ) did not show a significant reduction in FBG.…”

“…No significant effect of SGs on FBG was found in participants aged >50 years 19,20,24,[28][29][30]32 or with DM at baseline (Table 2). 19,20,24,28,29 Similarly, the high dosage of SGs (>250 mg d −1 ) did not show a significant reduction in FBG. Results from post hoc subgroup analyses revealed that there were no significant associations between SGs and FBG in adults with hypertension [30][31][32] and normal weight, 24,30,32,34 and in studies using capsules 19,20,24,[29][30][31][32][33] and with a follow-up duration >3 months.…”

“…HbA1c as an indicator of long-term glycemic control, represents the integrated glucose concentration over the preceding 8 to12 weeks. 56,57 There were six trials reporting data on HbA1c, 20,24,28,29,31,34 among which four studies enrolled participants with DM and one trial targeted participants with hypertension. No significant relationship between SGs and glucose metabolism was found in participants with DM or hypertension, as discussed above.…”