Evaluation of a New, Rapid Bedside Test for Quantitative Determination of B-Type Natriuretic Peptide

Fischer, Y.; Filzmaier, Karsten; Stiegler, H.; Graf, Jürgen; Fuhs, Simone; Franke, Andreas; Janssens, Uwe; Gressner, A. M.

doi:10.1093/clinchem/47.3.591

Cited by 83 publications

(19 citation statements)

References 12 publications

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“…(ProBNP values double per age decade. 13,28 ) A good correlation between BNP and proBNP (r 5 0.54-0.9) has been previously reported, 9,13,29 and these results have been confirmed. Two studies have compared the diagnostic performance of BNP and proBNP.…”

Section: Discussionsupporting

confidence: 74%

Comparison of Brain Natriuretic Peptide and Probrain Natriuretic Peptide in the Diagnosis of Cardiogenic Pulmonary Edema in Patients Aged 65 and Older

Ray¹,

Arthaud²,

Birolleau³

et al. 2005

J American Geriatrics Society

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Section: Discussionsupporting

confidence: 74%

Comparison of Brain Natriuretic Peptide and Probrain Natriuretic Peptide in the Diagnosis of Cardiogenic Pulmonary Edema in Patients Aged 65 and Older

Ray¹,

Arthaud²,

Birolleau³

et al. 2005

J American Geriatrics Society

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“…Plasma BNP and NT‐pro‐BNP levels in the present study were comparable with the baseline values of BNP and NT‐pro‐BNP shown in a recent study [23] by the Val‐HeFT group using the same commercial kits. The Triage Biosite BNP assay gives a value approximately 50% higher than that of the Shionogi assay (Triage BNP=1,579 (Shionogi) −2.947, r =0.963) [24]. Therefore, if the Triage BNP assay kit is used, the molar ratio of the transcardiac increase in NT‐pro‐BNP to the transcardiac increase of BNP would be lower than that reported in the present study.…”

Section: Discussioncontrasting

confidence: 73%

Direct comparison of transcardiac difference between brain natriuretic peptide (BNP) and N‐terminal pro‐BNP in patients with chronic heart failure

Tsutamoto

Ishikawa

Fujii

et al. 2007

European J of Heart Fail

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Background: Direct comparison of transcardiac increase in brain natriuretic peptide (BNP) and NT-pro-BNP has not been performed previously. Aims: To evaluate the relation between BNP and NT-pro-BNP secretion, plasma levels and renal function. Methods: We measured the plasma levels of BNP and NT-pro-BNP in the aortic root and coronary sinus in 326 consecutive patients with chronic heart failure (CHF). Patients were divided into two groups [group I: estimated glomerular filtration rate (eGFR) ≥ 60 mL/min and group II: eGFR b 60 mL/min]. Results: The molar level of the transcardiac increase in NT-pro-BNP is lower than that of BNP. There were no differences in haemodynamics or the transcardiac gradient of BNP and NT-pro-BNP between group I and group II. The molar ratio of the plasma NT-pro-BNP to BNP was significantly higher in group II than in group I. By stepwise multivariate analyses, not only the left ventricular (LV) ejection fraction and LVenddiastolic pressure, but also eGFR, LV mass index (LVMI) and haemoglobin were independent predictors of plasma NT-pro-BNP and BNP. Conclusion: The molar level of the transcardiac increase in NT-pro-BNP is lower than that of BNP; however, the influence of renal function on plasma NT-pro-BNP is greater than that on BNP.

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“…A rapid bedside BNP assay has several advantages compared with the formerly used assay systems to determine BNP [15]. The major advantage is its rapid and accurate measurement of BNP from whole blood with 24‐h availability in a routine laboratory or at the point of care.…”

Section: Discussionmentioning

confidence: 99%

“…We used a rapid bedside test for determination of BNP (Triage BNP TM ; Biosite Diagnostics, San Diego, CA, USA). The Triage BNP test is an immunofluorometric assay for quantitative determination of BNP in ethylenediaminetetraacetic acid (EDTA)‐anticoagulated whole blood or plasma [15]. Peripheral venous blood was collected in a sampling tube containing EDTA as the anticoagulant.…”

Section: Measurement Of Bnpmentioning

confidence: 99%

QRS prolongation on surface ECG and brain natriuretic peptide as indicators of left ventricular systolic dysfunction

Krüger¹,

Filzmaier²,

Graf³

et al. 2004

Journal of Internal Medicine

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Objective. To determine whether the combination of prolonged QRS duration and brain natriuretic peptide (BNP) levels predicts left ventricular systolic dysfunction (LVSD) with a higher accuracy compared with QRS duration or BNP alone. Setting. University hospital. Methods. We studied 128 consecutive patients with suspected cardiac disease. At rest the QRS duration on 12-lead ECG and BNP levels were determined. A left ventricular ejection fraction (LVEF) <50% at echocardiography was defined as LVSD. Results. QRS duration in the LVSD group (n ¼ 66, LVEF 30 ± 8%) was longer than in the group without LVSD (n ¼ 62, LVEF 60 ± 5%; QRS 129 ± 34 vs. 96 ± 20 ms, P < 0.001). BNP was higher in the LVSD group compared with controls (467 ± 397 vs. 169 ± 242 pg mL )1 , P < 0.001).A QRS duration of >0.1, >0.11 or >0.12 s was highly specific (63, 90 and 98%) but less sensitive (84, 81 and 75%) for the prediction of LVSD. A QRS cut-off value of 106 ms was moderately sensitive (65%) but very specific (87%) for the prediction of LVSD, whereas a BNP cut-off value of >84 pg mL )1 was highly sensitive (89%) but only modestly specific (58%). The positive likelihood ratio for LVSD of abnormal BNP (2.0) and QRS prolongation >0.1 s (2.3) was improved by the combination of both criteria (5.1). In multivariate analysis, BNP and QRS duration were independent predictors of LVSD.Conclusions. The combination of abnormal BNP and QRS prolongation yields a higher positive likelihood ratio for the detection of LVSD compared with the two criteria alone.

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Evaluation of a New, Rapid Bedside Test for Quantitative Determination of B-Type Natriuretic Peptide

Cited by 83 publications

References 12 publications

Comparison of Brain Natriuretic Peptide and Probrain Natriuretic Peptide in the Diagnosis of Cardiogenic Pulmonary Edema in Patients Aged 65 and Older

Comparison of Brain Natriuretic Peptide and Probrain Natriuretic Peptide in the Diagnosis of Cardiogenic Pulmonary Edema in Patients Aged 65 and Older

Direct comparison of transcardiac difference between brain natriuretic peptide (BNP) and N‐terminal pro‐BNP in patients with chronic heart failure

QRS prolongation on surface ECG and brain natriuretic peptide as indicators of left ventricular systolic dysfunction

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