Evaluation of a pen injector system for growth hormone treatment.

Gluckman, P. D.; Cutfield, WS

doi:10.1136/adc.66.6.686

Cited by 28 publications

(8 citation statements)

References 10 publications

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“…Há menor desperdício da medicação (19), menor chance de contaminação (20) e preparo menos complexo. Ademais, a aplicação por meio da caneta estaria associada a menores dependên-cias e erros de dosagem (19,21).…”

Section: Alternativas Para O Gh Subcutâneo Diário Canetasunclassified

Novas opções e preparações na terapia com hormônio de crescimento

Aguiar‐Oliveira

Meneguz‐Moreno

Nascimento-Junior

2008

Arq Bras Endocrinol Metab

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RESUMOnos últimos 20 anos, o hormônio de crescimento recombinante humano (gHhr) vem sendo utilizado para tratar a deficiência do hormônio de crescimento (gH) em crianças e, mais recentemente, em adultos. Porém, a necessidade de injeções diárias compromete a aderência ao tratamento. esforços de melhorar esta aderência incluem o uso de canetas e dispositivos desprovidos de agulha, haja vista que as bombas de infusão, nem sempre são fisiológicas e são de uso restrito. quando a finalidade do tratamento for o crescimento, a terapêutica diária com gHhr continua a mais recomendada. contudo, a expansão da terapêutica com gH, especialmente nos usos mais recentes e em adultos, necessitará de outras preparações. no momento atual, os secretagogos orais não têm eficácia comprovada para a utilização clínica, e as formulações de depósito de gHrH e de gH, que melhorariam a aderência dos pacientes, ainda requerem mais estudos de eficácia em longo prazo e segurança. ABSTRAcTNews Options and Preparations in Growth Hormone Therapy. in the last twenty years, recombinant human growth hormone (hrgH) has been available for the treatment of growth Hormone deficiency (gHd) in children and more recently in adults. However, the necessity of daily injections compromises the patient's compliance. Attempts to improve this compliance includes the use of pens and needle free devices, once the infusion pumps, not always physiologic, are of restricted use. When growth is the purpose of treatment, daily subcutaneous hrgH is still the most indicated. nevertheless the expansion of gH replacement to new uses and especially in adults will need new preparations. nowadays, the oral secretagogues have not proved efficacy to be used in clinical practice and the slow-release preparations of gH and gH releasing hormone that could improve the patient's compliance will need to be studied considering long term efficacy and safety. (1). Desde 1986, o GH recombinante humano (GHhr) vem sendo usado para tratar crianças com deficiência de GH (DGH) e déficit de crescimento (2,3). Posteriormente, foi reconhecido que o GH não é somente requerido

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Section: Alternativas Para O Gh Subcutâneo Diário Canetasunclassified

Novas opções e preparações na terapia com hormônio de crescimento

Aguiar‐Oliveira

Meneguz‐Moreno

Nascimento-Junior

2008

Arq Bras Endocrinol Metab

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“…It has been reported that pocket injection pens such as KabiPen [5][6][7] or Nordiject [8,9] are more convenient than the conventional syringe injection system for patients or parents. But the injection-pen system has some inconvenient problems as follows: the procedure for dissolving GH and setting a vial into the pen needs several steps, dose adjustment is necessary for each injection, GH solution which is intended for multi-dosing injection contains preservative and the weight of the pen is too heavy.…”

Section: Discussionmentioning

confidence: 99%

Multicenter Study on Clinical Evaluation of Disposable Syringes Pre-loaded with Growth Hormone (Genotropin KabiQuick)

Suwa

Tachibana

Ohyama

et al. 1993

Clin Pediatr Endocrinol

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“…This is reflected in the fact that many young patients do not undertake their own injections but rely on adults to perform the injections for them 4 . They can be painful, if large-gauge needles are used.…”

Section: Conventional Injection Technologymentioning

confidence: 99%

A History of Growth Hormone Injection Devices

Fidotti

2001

Journal of Pediatric Endocrinology and Metabolism

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In the early 1960s, growth hormone (GH) deficiency was treated by intramuscular injection of GH extracted from human pituitary glands. Since then, there have been many advances in treatment encompassing the route of administration, the injection product and the injection device. This review considers the advances in injection device that have already taken place and how they have benefited the patient, particularly in terms of reduced pain and improved convenience. In the future, needle-free injection techniques and depot formulations of GH are likely to offer alternatives to daily subcutaneous injections.

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Evaluation of a pen injector system for growth hormone treatment.

Cited by 28 publications

References 10 publications

Novas opções e preparações na terapia com hormônio de crescimento

Novas opções e preparações na terapia com hormônio de crescimento

Multicenter Study on Clinical Evaluation of Disposable Syringes Pre-loaded with Growth Hormone (Genotropin KabiQuick)

A History of Growth Hormone Injection Devices

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