Evaluation of a pulsed xenon ultraviolet light device for isolation room disinfection in a United Kingdom hospital

Hosein, I. K.; Madeloso, Rosie; Nagaratnam, Wijayaratnam; Villamaria, Frank J.; Stock, Eileen M.; Jinadatha, Chetan

doi:10.1016/j.ajic.2016.01.044

Cited by 46 publications

(62 citation statements)

References 23 publications

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“…Therefore, further data are needed to clearly determine the benefits of UV light, but enhanced terminal cleaning may be part of the solution. Some of the drawbacks for the use of automated methods has been cost‐effectiveness and logistical problems, including the ability of the systems to reach certain areas, the need for furniture rearrangement in the rooms for its use, and longer cleaning times of an average 1 hour per room . More recently, we were able to demonstrate equivalent efficiency in reduction of colony counts (approximately 73%) on high‐touch surface areas between cycles of 2 and 8 minutes using the PX‐UV system at a single position in the operating rooms …”

Section: Environmental Cleaningmentioning

confidence: 90%

Update on infection control practices in cancer hospitals

Ariza-Heredia

Chemaly

2018

CA A Cancer J Clinicians

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Therapies in oncology have evolved rapidly over the last years. At the same pace, supportive care for patients receiving cancer therapy has also evolved, allowing patients to safely receive the newest advances in treatment in both an inpatient and outpatient basis. The recognition of the role of infection control and prevention (ICP) in the outcomes of patients living with cancer has been such that it is now a requirement for hospitals and involves multidisciplinary groups. Some unique aspects of ICP for patients with cancer that have gained momentum over the past few decades include catheter-related infections, multidrug-resistant organisms, community-acquired viral infections, and the impact of the health care environment on the horizontal transmission of organisms. Furthermore, as the potential for infections to cross international borders has increased, alertness for outbreaks or new infections that occur outside the area have become constant. As the future approaches, ICP in immunocompromised hosts will continue to integrate emerging disciplines, such as antibiotic stewardship and the microbiome, and new techniques for environmental cleaning and for controlling the spread of infections, such as whole-genome sequencing. CA Cancer J Clin 2018;000:000-000. © 2018 American Cancer Society.

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Section: Environmental Cleaningmentioning

confidence: 90%

Update on infection control practices in cancer hospitals

Ariza-Heredia

Chemaly

2018

CA A Cancer J Clinicians

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“…Specifically, photodynamic inactivation (PDI) has been shown to be effective in the treatment of different bacteria, including antimicrobial resistant strains of bacteria (Maclean et al, 2010; Luksiene and Paskeviciute, 2011; Endarko et al, 2012; Murdoch et al, 2012; Bumah et al, 2015; Hosein et al, 2016). In the case of L. monocytogenes , light can decrease cell numbers in liquid culture, on surfaces and decrease its biofilm production meaning that PDI could be a very useful way of treating L. monocytogenes contamination in the food production environment (Murdoch et al, 2012; McKenzie et al, 2013; O’Donoghue et al, 2016).…”

Section: Methods Of Controlling L Monocytogenesmentioning

confidence: 99%

“…Light has previously been used as a method of bacterial decontamination both within clinical environments and on food products (Ozer and Demirci, 2006; Maclean et al, 2010; Hosein et al, 2016; Xu and Wu, 2016) and therefore may be useful as a means of controlling L. monocytogenes contamination within the food industry. Recently it has been shown that blue light triggers the activation of the GSR within L. monocytogenes and therefore should be considered as a stress for the bacterium (Ondrusch and Kreft, 2011; Tiensuu et al, 2013).…”

Section: Stresses Encountered In Foodmentioning

confidence: 99%

The Role of Stress and Stress Adaptations in Determining the Fate of the Bacterial Pathogen Listeria monocytogenes in the Food Chain

2016

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The foodborne pathogen Listeria monocytogenes is a highly adaptable organism that can persist in a wide range of environmental and food-related niches. The consumption of contaminated ready-to-eat foods can cause infections, termed listeriosis, in vulnerable humans, particularly those with weakened immune systems. Although these infections are comparatively rare they are associated with high mortality rates and therefore this pathogen has a significant impact on food safety. L. monocytogenes can adapt to and survive a wide range of stress conditions including low pH, low water activity, and low temperature, which makes it problematic for food producers who rely on these stresses for preservation. Stress tolerance in L. monocytogenes can be explained partially by the presence of the general stress response (GSR), a transcriptional response under the control of the alternative sigma factor sigma B (σB) that reconfigures gene transcription to provide homeostatic and protective functions to cope with the stress. Within the host σB also plays a key role in surviving the harsh conditions found in the gastrointestinal tract. As the infection progresses beyond the GI tract L. monocytogenes uses an intracellular infectious cycle to propagate, spread and remain protected from the host’s humoral immunity. Many of the virulence genes that facilitate this infectious cycle are under the control of a master transcriptional regulator called PrfA. In this review we consider the environmental reservoirs that enable L. monocytogenes to gain access to the food chain and discuss the stresses that the pathogen must overcome to survive and grow in these environments. The overlap that exists between stress tolerance and virulence is described. We review the principal measures that are used to control the pathogen and point to exciting new approaches that might provide improved means of control in the future.

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“…Pulsed xenon ultraviolet (PX-UV) is proven as an effective tool for disinfection of pathogens in various hospital settings, including wards [2][3][4][5][6], operating rooms [7], surgical sites [8,9], nursing rooms [10], human milk feeding rooms [11], and burns units [12]; and this disinfectant effect also applies to clinical laboratories and blood sampling rooms in China [13,14]. However, the effectiveness of PX-UV in disinfection of a hospital animal laboratory is unstudied.…”

Section: Introductionsmentioning

confidence: 99%

Portable pulsed xenon ultraviolet light disinfection in a teaching hospital animal laboratory in China

Wang

Qiao

et al. 2020

Journal of Photochemistry and Photobiology B: Biology

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Evaluation of a pulsed xenon ultraviolet light device for isolation room disinfection in a United Kingdom hospital

Abstract: PX-UV use decreased bioburden in patient discharge rooms and on agar plates spiked with MDROs. The implementation of the PX-UV device was well received by hospital cleaning and ward staff, with minimal disruption to patient flow.

Cited by 46 publications

References 23 publications

Update on infection control practices in cancer hospitals

Update on infection control practices in cancer hospitals

The Role of Stress and Stress Adaptations in Determining the Fate of the Bacterial Pathogen Listeria monocytogenes in the Food Chain

Portable pulsed xenon ultraviolet light disinfection in a teaching hospital animal laboratory in China

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