Evaluation of Acetaminophen Release from Biodegradable Poly (Vinyl Alcohol) (PVA) and Nanocellulose Films Using a Multiphase Release Mechanism

O'Donnell, Kelsey; Oporto, Gloria S.; Comolli, Noelle

doi:10.3390/nano10020301

Cited by 20 publications

(20 citation statements)

References 31 publications

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“…As well, O’Donnell et al performed a study for evaluation of acetaminophen release from biodegradable PVA and nanocellulose films. It revealed that the fraction of burst release increased with increasing drug concentration in the initial formulations and this accounts for drug attached to the surface of the film and release, rather than being entrapped deeper in the polymer matrix [ 69 ].…”

Section: Resultsmentioning

confidence: 99%

Green Nanotechnology in the Formulation of a Novel Solid Dispersed Multilayered Core-Sheath Raloxifene-Loaded Nanofibrous Buccal Film; In Vitro and In Vivo Characterization

et al. 2021

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Green nanotechnology utilizes the principles of green chemistry to formulate eco-friendly nanocarrier systems to mitigate patients and environment hazards. Raloxifene (RLX) demonstrates poor aqueous solubility (BCS class II) and low bioavailability, only 2% (extensive first-pass metabolism). The aim of this study is to enhance RLX solubility and bioavailability via development of novel solid dispersed multilayered core-sheath RLX-loaded nanofibers (RLX-NFs) without the involvement of organic solvents. A modified emulsion electrospinning technique was developed. Electrospinning of an RLX-nanoemulsion (RLX-NE) with polymer solution (poly vinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), and chitosan (CS) in different volume ratios (1:9, 2:8, and 4:6) using D-optimal response surface methodology was adopted. In vitro characterization of RLX-loaded NFs was performed; scanning electron microscope (SEM), thermal analysis, drug content, release studies, and bioadhesion potential. The optimum NFs formula was evaluated for morphology using high-resolution transmission electron microscopy (HRTEM), and ex vivo drug permeation. The superiority of E2 (comprising RLX-NE and PVA (2:8)) over other NF formulae was statistically observed with respect to Q60 (56.048%), Q240 (94.612%), fiber size (594.678 nm), mucoadhesion time 24 h, flux (5.51 µg/cm2/h), and enhancement ratio (2.12). RLX pharmacokinetics parameters were evaluated in rabbits following buccal application of NF formula E2, relative to RLX oral dispersion. E2 showed significantly higher Cmax (53.18 ± 4.56 ng/mL), and relative bioavailability (≈2.29-fold).

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Section: Resultsmentioning

confidence: 99%

Green Nanotechnology in the Formulation of a Novel Solid Dispersed Multilayered Core-Sheath Raloxifene-Loaded Nanofibrous Buccal Film; In Vitro and In Vivo Characterization

et al. 2021

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“…Fickian diffusion [83] CNFs/polyvinyl alcohol films Acetaminophen -Diffusion controlled and burst release [145] BC composite membranes…”

Section: Hydrophilic-drug Release Behaviorsmentioning

confidence: 99%

Nanocellulose-Based Composite Materials Used in Drug Delivery Systems

et al. 2022

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Nanocellulose has lately emerged as one of the most promising “green” materials due to its unique properties. Nanocellulose can be mainly divided into three types, i.e., cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial cellulose (BC). With the rapid development of technology, nanocellulose has been designed into multidimensional structures, including 1D (nanofibers, microparticles), 2D (films), and 3D (hydrogels, aerogels) materials. Due to its adaptable surface chemistry, high surface area, biocompatibility, and biodegradability, nanocellulose-based composite materials can be further transformed as drug delivery carriers. Herein, nanocellulose-based composite material used for drug delivery was reviewed. The typical drug release behaviors and the drug release mechanisms of nanocellulose-based composite materials were further summarized, and the potential application of nanocellulose-based composite materials was prospected as well.

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“…The nanocellulose debris was reported to serve as solid lubricant between metal and polymer surface, thus prevented further abrasion of UHMWPE, with relatively low wear volume as compared to neat UHMPWE. Additionally, nanocelluloses are biocompatible and non-toxic by which it can be used in many biomaterials application such as for wound dressings materials [ 14 , 15 , 16 ], scaffold for bone or tissue regeneration [ 17 , 18 , 19 ], carrier for drug deliveries [ 20 , 21 , 22 , 23 , 24 ] and many more [ 25 , 26 , 27 , 28 ]. These properties of nanocellulose make it an excellent material as UHMWPE fillers, particularly for artificial joint application.…”

Section: Introductionmentioning

confidence: 99%

Melt- vs. Non-Melt Blending of Complexly Processable Ultra-High Molecular Weight Polyethylene/Cellulose Nanofiber Bionanocomposite

et al. 2021

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The major hurdle in melt-processing of ultra-high molecular weight polyethylene (UHMWPE) nanocomposite lies on the high melt viscosity of the UHMWPE, which may contribute to poor dispersion and distribution of the nanofiller. In this study, UHMWPE/cellulose nanofiber (UHMWPE/CNF) bionanocomposites were prepared by two different blending methods: (i) melt blending at 150 °C in a triple screw kneading extruder, and (ii) non-melt blending by ethanol mixing at room temperature. Results showed that melt-processing of UHMWPE without CNF (MB-UHMWPE/0) exhibited an increment in yield strength and Young’s modulus by 15% and 25%, respectively, compared to the Neat-UHMWPE. Tensile strength was however reduced by almost half. Ethanol mixed sample without CNF (EM-UHMWPE/0) on the other hand showed slight decrement in all mechanical properties tested. At 0.5% CNF inclusion, the mechanical properties of melt-blended bionanocomposites (MB-UHMWPE/0.5) were improved as compared to Neat-UHMWPE. It was also found that the yield strength, elongation at break, Young’s modulus, toughness and crystallinity of MB-UHMWPE/0.5 were higher by 28%, 61%, 47%, 45% and 11%, respectively, as compared to the ethanol mixing sample (EM-UHMWPE/0.5). Despite the reduction in tensile strength of MB-UHMWPE/0.5, the value i.e., 28.4 ± 1.0 MPa surpassed the minimum requirement of standard specification for fabricated UHMWPE in surgical implant application. Overall, melt-blending processing is more suitable for the preparation of UHMWPE/CNF bionanocomposites as exhibited by their characteristics presented herein. A better mechanical interlocking between UHMWPE and CNF at high temperature mixing with kneading was evident through FE-SEM observation, explains the higher mechanical properties of MB-UHMWPE/0.5 as compared to EM-UHMWPE/0.5.

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Evaluation of Acetaminophen Release from Biodegradable Poly (Vinyl Alcohol) (PVA) and Nanocellulose Films Using a Multiphase Release Mechanism

Cited by 20 publications

References 31 publications

Green Nanotechnology in the Formulation of a Novel Solid Dispersed Multilayered Core-Sheath Raloxifene-Loaded Nanofibrous Buccal Film; In Vitro and In Vivo Characterization

Green Nanotechnology in the Formulation of a Novel Solid Dispersed Multilayered Core-Sheath Raloxifene-Loaded Nanofibrous Buccal Film; In Vitro and In Vivo Characterization

Nanocellulose-Based Composite Materials Used in Drug Delivery Systems

Melt- vs. Non-Melt Blending of Complexly Processable Ultra-High Molecular Weight Polyethylene/Cellulose Nanofiber Bionanocomposite

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