Evaluation of Achilles Reflex Time as a Test of Thyroid Function

Gupta, Seema; Kumar, Vijay; Mm, Ahuja

doi:10.1097/00007611-197307000-00004

Cited by 4 publications

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Spectrum of quality of life impairment in hypothyroidism

et al. 1994

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The aim of this study is to evaluate the frequency and relative importance of different aspects of health related quality of life (HRQOL) impairment in patients with hypothyroidism. A survey of 200 patients with treated hypothyroidism was undertaken. Patients were identified and questionnaires distributed through family physicians, endocrinologists, and regional branches of the Thyroid Foundation of Canada. Frequency of importance of patients' symptoms attributed to hypothyroidism and resolved or improved with treatment were measured. Establishing the wide variety of patient-specific complaints associated with hypothyroidism provides guidance for clinicians dealing with hypothyroid patients, and investigators interested in HRQOL impairment in these patients.

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Spectrum of quality of life impairment in hypothyroidism

et al. 1994

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Endocrinological Signs

Dennis¹,

Bowen²,

Cho³

2012

Mechanisms of Clinical Signs

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A Pituitary Tumor in a Patient with Thyroid Hormone Resistance: A Diagnostic Dilemma

Safer

Colan

Fraser

et al. 2001

Thyroid

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Resistance to thyroid hormone (RTH) is due to mutations in the beta-isoform of the thyroid hormone receptor (TR-beta). RTH patients display inappropriate secretion of thyrotropin-releasing hormone (TRH) from the hypothalamus and thyrotropin (TSH) from the anterior pituitary, despite elevated levels of thyroid hormone thyroxine (T4) and triiodothyronine (T3). Thyrotropin-secreting tumors are presumed to represent clonal expansion of abnormal cells. Because the diagnosis of TSH-secreting tumors tends to be delayed and curative surgical resection remains under 50%, early diagnosis is paramount. Current diagnostic strategies suggest that RTH patients are distinguishable from patients with TSH-secreting pituitary tumors by the use of standard laboratory tests and imaging. Here, we present a woman in whom the standard evaluation for inappropriate TSH secretion was insufficient to distinguish these entities. The patient had a low-normal TRH stimulation test and an unmeasurable alpha-glycoprotein subunit level; however, a pituitary magnetic resonance imaging (MRI) revealed an adenoma. More testing using a T3 suppression test supported a RTH diagnosis and a R438H mutation was found in the TR-beta gene. To our knowledge, this represents the first report of an apparently incidental pituitary adenoma in the setting of documented resistance to thyroid hormone. As such, it raises the question of whether RTH predisposes to pituitary hyperplasia and adenoma development.

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Evaluation of Achilles Reflex Time as a Test of Thyroid Function

Cited by 4 publications

References 0 publications

Spectrum of quality of life impairment in hypothyroidism

Spectrum of quality of life impairment in hypothyroidism

Endocrinological Signs

A Pituitary Tumor in a Patient with Thyroid Hormone Resistance: A Diagnostic Dilemma

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