Evaluation of acoustic radiation force impulse (ARFI) elastography as non-invasive diagnostic tool in living donor liver transplantation

Abdel-Haleem, Hanan; Eldeen, Hadeel Gamal; Nabeel, Mohamed Mahmoud; Abdelmoniem, Reham; Elakel, Wafaa; Abdellatif, Zeinab; Monir, Bahaa; Said, Mohamed; Mogawer, Sherif; El-Amir, Mona; Elshazli, Mostafa; Salah, Ayman; Hosny, Adel; Yosry, Ayman

doi:10.1007/s00261-018-1732-8

Cited by 7 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After exclusion of the studies by title/abstract and other publication types, 89 studies were carefully assessed for eligibility. Then, the studies concentrating on viral hepatitis, animal models and those without sufficient data were excluded, and a total of 29 studies were included for further analysis [9, (Fig 1). Among them, two studies concentrated on ARFI on biliary atresia-related hepatic fibrosis, two studies reported ARFI in diagnosing fibrosis caused by cystic fibrosis-associated liver disease.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…For instance, only 1/50000 of the whole liver tissue is sampled during a liver biopsy, for which sampling error is of concern [8]. The length of the specimens or the choice of the biopsy location might affect the accuracy of the results [9]. Moreover, repeated biopsies are infeasible in clinical settings for the sake of continuous monitoring of fibrosis grade [10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The diagnostic accuracy of liver fibrosis in non-viral liver diseases using acoustic radiation force impulse elastography: A systematic review and meta-analysis

Lin

Jin

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

BackgroundAcoustic radiation force impulse (ARFI) imaging is an ultrasound-based elastography method that has been studied in the staging of hepatic fibrosis, especially in chronic hepatitis. However, the diagnostic accuracy of ARFI in non-viral hepatopathies, such as autoimmune hepatitis and non-alcoholic fatty liver disease, has not been systematically determined. OPEN ACCESSCitation: Lin Y, Li H, Jin C, Wang H, Jiang B (2020) The diagnostic accuracy of liver fibrosis in non-viral liver diseases using acoustic radiation force impulse elastography: A systematic review and meta-analysis. PLoS ONE 15(1): e0227358. https://

show abstract

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The diagnostic accuracy of liver fibrosis in non-viral liver diseases using acoustic radiation force impulse elastography: A systematic review and meta-analysis

Lin

Jin

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Compared to other studies, the sample size for ARFI ( n = 69) was quite large (Abdelhaleem et al 2018: n = 70; Liao et al 2014: n = 57, Schmillevitch et al 2016: n = 33) ( 4 , 5 , 21 , 22 ). The cut-off at 1.29 m/s was more within the lower range of most other studies on ARFI in OLT recipients dominated by HCV reinfection, in which cut-off values ranged between 1.29 m/s and 1.75 m/s ( 4 , 23 – 25 ).…”

Section: Discussionmentioning

confidence: 80%

“…Through this, shear waves are propagated and their velocity can be measured in a certain region of interest. Results are described in m/s ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Prospective comparison of liver stiffness measurement methods in surveillance biopsies after liver transplantation

Bosselmann,

Engel,

Hartleben

et al. 2023

Front. Transplant.

View full text Add to dashboard Cite

BackgroundLiver stiffness measurements (LSMs) have proven useful for non-invasive detection of fibrosis. Previous studies of LSMs after transplantation were performed in cohorts dominated by hepatitis C reinfections and indication biopsies for the evaluation of graft dysfunction. However, the diagnostic fidelity of LSMs for fibrosis is biased by inflammation e.g., during replicative hepatitis C or rejection.Materials and methodsThe current study aimed for a head-to-head comparison of two different LSMs, acoustic radiation force impulse (ARFI) and transient elastography (TE), and a determination of cut-off values for the detection of advanced fibrosis (any LAF score component ≥2) in grafts undergoing surveillance biopsies (svLbx) without recurrent hepatitis C.Results103 svLbx were paired with valid LSMs at time of biopsy. AUROC analyses showed significant positive correlation with fibrosis for both methods (TE: AUROC = 0.819 (p < 0.001; 95%CI: 0.717–0.921); ARFI: AUROC = 0.771 (p = 0.001; 95%CI: 0.652–0.890). Patients were randomly assigned to training and validation cohorts for both LSM methods. Cut-off values were determined at 1.29 m/s (ARFI) and at 7.5 kPa (TE) in training cohorts. Sensitivity and specificity in training and validation cohorts were: TE: SEN 0.818 and 0.5; SPE 0.742 and 0.885; ARFI: SEN 0.818 and 1.0; SPE 0.75 and 0.586. LSMs were not associated with BANFF criteria for relevant graft injury.ConclusionLSM is a good non-invasive tool to screen for advanced graft fibrosis but not for relevant graft injury in patients with (near) normal liver enzymes. Fibrosis cut-off values identified and validated in svLbx were lower than in previous cohorts using indication biopsies.

show abstract

“…124 In addition to its practical use in the clinic, studies have shown that ARFI performs comparably to TE and is applicable to both adult and pediatric populations. [125][126][127][128][129][130][131][132][133] Meanwhile, SWE quantifies stiffness similarly to TE with the advantage of measuring liver stiffness in several regions of interest in real time. 134 However, SWE tends to have lower performance metrics compared with ARFI and TE in LT recipients; thus, its use may be limited in the clinic.…”

Section: Imaging Modalitiesmentioning

confidence: 99%

A Comprehensive Review of Liver Allograft Fibrosis and Steatosis: From Cause to Diagnosis

Rabindranath,

Zaya,

Prayitno

et al. 2023

Transplantation Direct

View full text Add to dashboard Cite

Despite advances in posttransplant care, long-term outcomes for liver transplant recipients remain unchanged. Approximately 25% of recipients will advance to graft cirrhosis and require retransplantation. Graft fibrosis progresses in the context of de novo or recurrent disease. Recurrent hepatitis C virus infection was previously the most important cause of graft failure but is now curable in the majority of patients. However, with an increasing prevalence of obesity and diabetes and nonalcoholic fatty liver disease as the most rapidly increasing indication for liver transplantation, metabolic dysfunction-associated liver injury is anticipated to become an important cause of graft fibrosis alongside alloimmune hepatitis and alcoholic liver disease. To better understand the landscape of the graft fibrosis literature, we summarize the associated epidemiology, cause, potential mechanisms, diagnosis, and complications. We additionally highlight the need for better noninvasive methods to ameliorate the management of graft fibrosis. Some examples include leveraging the microbiome, genetic, and machine learning methods to address these limitations. Overall, graft fibrosis is routinely seen by transplant clinicians, but it requires a better understanding of its underlying biology and contributors that can help inform diagnostic and therapeutic practices.

show abstract

Evaluation of acoustic radiation force impulse (ARFI) elastography as non-invasive diagnostic tool in living donor liver transplantation

Abstract: ARFI can be used as a reliable method in assessment of significant fibrosis post-LDLT.

Cited by 7 publications

References 30 publications

The diagnostic accuracy of liver fibrosis in non-viral liver diseases using acoustic radiation force impulse elastography: A systematic review and meta-analysis

The diagnostic accuracy of liver fibrosis in non-viral liver diseases using acoustic radiation force impulse elastography: A systematic review and meta-analysis

Prospective comparison of liver stiffness measurement methods in surveillance biopsies after liver transplantation

A Comprehensive Review of Liver Allograft Fibrosis and Steatosis: From Cause to Diagnosis

Contact Info

Product

Resources

About