The diagnostic accuracy of liver fibrosis in non-viral liver diseases using acoustic radiation force impulse elastography: A systematic review and meta-analysis

Lin, Yuanqiang; Li, Hequn; Jin, Chunxiang; Wang, Hui; Jiang, Bo

doi:10.1371/journal.pone.0227358

Cited by 34 publications

(38 citation statements)

References 56 publications

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“…Since 2015 there have been numerous publications and meta-analyses regarding the accuracy of pSWE and 2D-SWE for liver fibrosis staging in comparison to liver biopsy. In addition to the data already available for HCV and HBV, suggesting accuracies similar to TE, a metaanalysis on the performance of pSWE in 29 studies in patients with chronic liver disease due to non-viral aetiologies 253 showed an AUROC of 0.94 for advanced fibrosis and cirrhosis.…”

Section: Compensated Advanced Chronic Liver Disease and Portal Hypertensionmentioning

confidence: 90%

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update

Berzigotti¹,

Tsochatzis²,

Boursier³

et al. 2021

Journal of Hepatology

1,010

615

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Section: Compensated Advanced Chronic Liver Disease and Portal Hypertensionmentioning

confidence: 90%

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update

Berzigotti¹,

Tsochatzis²,

Boursier³

et al. 2021

Journal of Hepatology

1,010

615

View full text Add to dashboard Cite

show abstract

“…However, a recent systematic review and meta-analysis suggests that ARFI is an acceptable diagnostic tool in staging hepatic fibrosis of non-viral origin, in particular in the case of severe fibrosis (F ≥3). 57 …”

Section: Discussionmentioning

confidence: 99%

“…A recent analysis, however, indicated ARFI as a suitable tool in staging liver fibrosis of non-viral origin, mainly in the case of severe fibrosis. 57 By contrast, over- or underestimation of the anatomo-pathological results is also possible following liver histology. 10 , 11 …”

Section: Discussionmentioning

confidence: 99%

(13C)-Methacetin breath test provides evidence of subclinical liver dysfunction linked to fat storage but not lifestyle

et al. 2021

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Background & Aims Non-alcoholic fatty liver disease (NAFLD) is characterised by the presence of hepatic steatosis in the absence of other causes of secondary hepatic fat accumulation, and is usually associated with visceral, metabolically active obesity. However, the subclinical effects of body and liver fat accumulation on liver function are still unclear. Methods We used orally administered ( 13 C)-methacetin and breath test to quantify the efficiency of hepatic extraction from portal blood flow and liver microsomal function in 81 participants, in relation to presence/absence of ultrasonographic NAFLD, extent of body fat accumulation, insulin resistance, dietary models, and lifestyle. Results NAFLD was present in 23% of participants with normal weight, and prevalence increased with body fat and insulin resistance. Fat accumulation, NAFLD, and insulin resistance were associated with decreased hepatic extraction efficiency, and liver microsomal function was impaired in moderate-to-severe NAFLD. Caloric intake, dietary models, and lifestyles had a minor role in promoting functional changes. Conclusions The interplay between body fat accumulation, insulin resistance, and NAFLD is linked with altered hepatic extraction efficiency from blood flow and deranged microsomal function. Non-invasive diagnosis of subclinical alterations of liver function is relevant for primary and secondary prevention measures. Furthermore, the occurrence of NAFLD in lean individuals and the evidence that caloric intake, dietary models, and lifestyle played a minor role require further studies exploring the role of environmental factors in the natural history of these diseases. Lay summary Obesity is progressively increasing worldwide and is paralleled by fat accumulation in the liver (non-alcoholic fatty liver disease [NAFLD]), the most common chronic liver disease worldwide. NAFLD can alter liver structure and function, with a variety of consequences ranging from asymptomatic and subclinical alterations to cirrhosis and cancer. ( 13 C)-Methacetin breath test, a non-invasive diagnostic tool, can reveal early subclinical alterations of liver dynamic function in individuals with obesity and in patients with NAFLD.

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“…The examiner is able to use grayscale ultrasound imaging to locate a small region of interest (ROI) in the right hepatic lobe, avoiding large vessels and the gallbladder. The diagnostic performance of SWE, as reported in a meta-analysis, is demonstrated in Table 1 [ 12 , 13 ]. The advantage of point shear wave elastography is that it can be performed under B-mode ultrasound, so tumors and large vessels can be avoided.…”

Section: Noninvasive Imaging Techniquesmentioning

confidence: 99%

Noninvasive Assessment of Liver Fibrosis: Current and Future Clinical and Molecular Perspectives

Masuzaki

Sasaki

Matsumoto

et al. 2020

IJMS

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Liver fibrosis is one of the risk factors for hepatocellular carcinoma (HCC) development. The staging of liver fibrosis can be evaluated only via a liver biopsy, which is an invasive procedure. Noninvasive methods for the diagnosis of liver fibrosis can be divided into morphological tests such as elastography and serum biochemical tests. Transient elastography is reported to have excellent performance in the diagnosis of liver fibrosis and has been accepted as a useful tool for the prediction of HCC development and other clinical outcomes. Two-dimensional shear wave elastography is a new technique and provides a real-time stiffness image. Serum fibrosis markers have been studied based on the mechanism of fibrogenesis and fibrolysis. In the healthy liver, homeostasis of the extracellular matrix is maintained directly by enzymes called matrix metalloproteinases (MMPs) and their specific inhibitors, tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs could be useful serum biomarkers for liver fibrosis and promising candidates for the treatment of liver fibrosis. Further studies are required to establish liver fibrosis-specific markers based on further clinical and molecular research. In this review, we summarize noninvasive fibrosis tests and molecular mechanism of liver fibrosis in current daily clinical practice.

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The diagnostic accuracy of liver fibrosis in non-viral liver diseases using acoustic radiation force impulse elastography: A systematic review and meta-analysis

Cited by 34 publications

References 56 publications

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update

(13C)-Methacetin breath test provides evidence of subclinical liver dysfunction linked to fat storage but not lifestyle

Noninvasive Assessment of Liver Fibrosis: Current and Future Clinical and Molecular Perspectives

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