Evaluation of activated charcoal and lipid emulsion treatment in model of acute rivaroxaban toxicity

Uzunget, Sinan Cem; Evrın, Togay; Uzunget, Sezen Bağlan; Ertürk, Zamir Kemal; Akincioglu, Egemen; Özdemir, Saffet; Korkmaz, Ali

doi:10.1016/j.ajem.2017.12.039

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…There are several case reports in the literature conducted on development of spontaneous haematoma in patients who take coumadin [11]. Although the use of new-generation oral anticoagulants like rivaroxaban is increasing, studies on their toxic effects are limited in the literature [12]. There were no studies conducted on soft tissue haematoma after traumas in patients who receive anticoagulants.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound use of post-traumatic gluteal haematoma in a patient using warfarin

Demir

Kazancı

Smereka

et al. 2019

Disaster Emerg Med J

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Most of the muscle pathologies consist of traumas. The use of oral anticoagulants increases post-traumatic bleeding and haematoma risk. Ultrasonography has an important place in diagnostic examination of the soft tissue haematomas that appear in post-traumatic period. In this study a patient is presented who used warfarin and was admitted at the emergency department with hip pain and difficulty in walking, and who had gluteal haematoma on ultrasound after falling down. Hip pains in patients using warfarin must be alarming in terms of gluteal haematoma. Ultrasound offers fast and reliable results in preventing complications.

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Section: Discussionmentioning

confidence: 99%

Ultrasound use of post-traumatic gluteal haematoma in a patient using warfarin

Demir

Kazancı

Smereka

et al. 2019

Disaster Emerg Med J

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Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose

Hoegberg

Shepherd

Wood

et al. 2021

Clinical Toxicology

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Evaluation of Lipid Emulsion-Mediated Sequestration and Redistribution of the Highly Lipophilic Carbamazepine in the Plasma of Rats

Ekşioğlu,

Algedik Gürsoy,

Sümer

et al. 2024

Anatolian Journal of Emergency Medicine

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Aim: The idea that intravenous lipid emulsion (ILE) may serve as a "reservoir" for lipophilic drugs has emerged in research as an intravascular "lipid sink" effect. Carbamazepine (CBZ) is a widely used anticonvulsant. This compound has a neutral and highly lipophilic structure and can easily cross body membranes. In this study, our hypothesis focused on the potential efficacy of ILE in modulating blood carbamazepine concentrations. Material and Methods: 22 adult Sprague-Dawley rats were divided into four groups. All groups received CBZ at a dose of 20 mg/kg orogastrically. The first group was the control group. In the second group (activated charcoal group), activated charcoal (AC) was administered orogastrically at a dose of 1 g/kg five minutes after orogastric administration of carbamazepine. The third group (lipid group) received ILE at a dose of 3 ml/kg/min at the fifth minute. The fourth group was the saline group, in which 16 ml/kg of 0.9% NaCl was infused at the fifth minute. Blood samples of 0.5 ml were collected at 0, 4, 8, and 24 hours. Plasma was separated by centrifugation (4000 rpm, 10 minutes) and stored at -80oC for determination of CBZ concentrations. An Agilent 6410B HP-1200 LC series (USA) liquid chromatography system was used for analysis. Quantitative analysis was performed in the multiple reaction mode with electrospray positive ionization (ES+). Results: At the 8th hour of orogastric CBZ administration, CBZ concentration was significantly lower in the activated charcoal group than in the lipid and saline groups (p: 0.021; p: 0.023; p0.05). In the lipid group, the increase in CBZ plasma concentrations was statistically significant at 4 and 8 hours compared to 0 hours (p: 0.005; p: 0.005, respectively). Conclusion: In the lipid group, plasma CBZ concentrations increased at 4 and 8 hours in plasma samples from which lipids were separated by differential centrifugation. In the lipid group, no effects favoring drug-lipid sequestration on the plasma distribution of CBZ were observed.

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Evaluation of activated charcoal and lipid emulsion treatment in model of acute rivaroxaban toxicity

Cited by 3 publications

References 34 publications

Ultrasound use of post-traumatic gluteal haematoma in a patient using warfarin

Ultrasound use of post-traumatic gluteal haematoma in a patient using warfarin

Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose

Evaluation of Lipid Emulsion-Mediated Sequestration and Redistribution of the Highly Lipophilic Carbamazepine in the Plasma of Rats

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