Evaluation of acute and subacute toxicity and mutagenic activity of the aqueous extract of pecan shells [Carya illinoinensis (Wangenh.) K. Koch]

Porto, Luiz Carlos Santos; Silva, Juliana da; Ferraz, Alexandre de Barros Falcão; Corrêa, Dione Silva; Santos, Marcelo Soares Teles; Porto, Caroline Dalla Lana; Picada, Jaqueline Nascimento

doi:10.1016/j.fct.2013.06.048

Cited by 24 publications

(16 citation statements)

References 27 publications

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“…Several possible mechanisms could induce these antidiabetic effects, including the induction of hypoglycemia, which is thought to stimulate the pancreatic insulin secretion from the β cells of the islets of Langerhans and aldose reductase enzyme inhibitory activity. In addition, PSAE treatment of nondiabetic rats has been reported to cause a slight decrease in body weight [5], which is in agreement with results obtained. Thus, pecan shell decoctions might prevent diabetes or contribute with the classical diabetes mellitus treatment.…”

Section: Resultssupporting

confidence: 90%

“…Phenols, tannins, gallic and ellagic acid [5] are present in greater amounts in the pecan shells than in the kernels [3,6]. Their biological activities may decrease inflammation in diabetes and obesity.…”

Section: Resultsmentioning

confidence: 98%

“…The phenolic constituents of the pecan shell, such as ellagic and gallic acids, decrease the severity of diabetes by suppressing the glucose level, significantly reducing the plasma cholesterol and triglyceride levels, and increasing the hepatic glucokinase activity by enhancing insulin release from pancreatic islet cells [17]. Ellagic acid, found in amounts of 1800 μg/g PSAE [5], decreased glucose and triglyceride levels in mice treated with 10 mg/kg b.w. ellagic acid for three consecutive days (Porto et al, in prep.).…”

Section: Resultsmentioning

confidence: 99%

“…Industrial processing of pecans generates a large amount of shells (40-50 %) that could be used medicinally. The pecan shell aqueous extract (PSAE) is rich in several phenolic compounds with antioxidant properties [3,5,6]. The protective effects of pecan shells have been described extensively, with one study using PSAE showing protective effects against cyclophosphamide-induced toxicity [7].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, in sub-chronic toxicity tests in rats, PSAE was safely used at the dose of 100 mg/kg body weight (b.w. )/ day for 28 days [5].…”

Section: Introductionmentioning

confidence: 99%

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The Antidiabetic and Antihypercholesterolemic Effects of an Aqueous Extract from Pecan Shells in Wistar Rats

Porto

Silva

Ferraz

et al. 2015

Plant Foods Hum Nutr

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Pecan shell decoction has been used to treat diabetes and obesity-related diseases. In this study, the effects of a pecan shell aqueous extract (PSAE) were evaluated in diabetic and hypercholesterolemic Wistar rats, analyzing clinical signs and biochemical as well as genotoxic and mutagenic parameters, to assess its safe use and efficacy. Diabetes mellitus and hypercholesterolemia were induced with streptozotocin (STZ) and tyloxapol, respectively. Animals were orally administered PSAE (100 mg/kg body weight, b.w.) for 28 days. Biochemical analyses and genotoxicity were evaluated in blood samples and mutagenicity was evaluated in bone marrow. PSAE treatment decreased the blood glucose level and stabilized clinical signs of diabetes in diabetic rats. PSAE diminished the increase in total cholesterol and triglyceride levels in hypercholesterolemic rats. The urea levels were higher in diabetic rats than in treated ones; however, creatinine values were the same in all groups. Elevated transaminase levels were suggestive of liver injuries in diabetic rats, and were not altered by PSAE treatment. PSAE did not show genotoxic or mutagenic activities in diabetic and hypercholesterolemic rats, indicating its safe use at 100 mg/kg b.w. not only in healthy rats but also in rats with induced metabolic alterations. The findings on PSAE's efficacy may indicate that its successful and popular use is in accordance with our results. Thus, PSAE might be a potential candidate for medical purposes as a complementary treatment of diabetes and hypercholesterolemia.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Furthermore, in sub-chronic toxicity tests in rats, PSAE was safely used at the dose of 100 mg/kg body weight (b.w. )/ day for 28 days [5].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Antidiabetic and Antihypercholesterolemic Effects of an Aqueous Extract from Pecan Shells in Wistar Rats

Porto

Silva

Ferraz

et al. 2015

Plant Foods Hum Nutr

Self Cite

View full text Add to dashboard Cite

show abstract

Pecans (Carya illinoinensis)

Gallegos‐Infante

Rocha‐Guzmán

González‐Laredo

et al. 2017

Fruit and Vegetable Phytochemicals

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Reuse of Different Agroindustrial Wastes: Pinhão and Pecan Nutshells Incorporated into Biocomposites Using Thermocompression

et al. 2020

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The development of cassava starch-based biocomposites incorporated with pecan nutshells and pinhão shells by thermocompression process was evaluated. The biocomposites were characterized in terms of thickness, bulk density, hydrophilicity, water absorption capacity (WAC), morphology, thermal and mechanical properties. The samples with residues incorporation showed lower WAC when compared to the control ones, for all evaluated times. Biocomposites containing the pinhão shells showed hydrophobic character, measured by the contact angle (greater than 90°). More irregularities were evidenced by the morphological analysis for the biocomposites added with pecan nutshells. The thermal stability of the biocomposites was influenced by the high lignin content in the residues. Regarding the mechanical properties, in both tensile and flexural tests, biocomposites containing pecan nutshells presented the lowest values of stress at break and modulus of elasticity. When compared to the control sample, the composites added with the pinhão shells had mechanical similar properties, differently from the result for samples incorporated with pecan nutshells that presented less resistant.

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Evaluation of acute and subacute toxicity and mutagenic activity of the aqueous extract of pecan shells [Carya illinoinensis (Wangenh.) K. Koch]

Cited by 24 publications

References 27 publications

The Antidiabetic and Antihypercholesterolemic Effects of an Aqueous Extract from Pecan Shells in Wistar Rats

The Antidiabetic and Antihypercholesterolemic Effects of an Aqueous Extract from Pecan Shells in Wistar Rats

Pecans (Carya illinoinensis)

Reuse of Different Agroindustrial Wastes: Pinhão and Pecan Nutshells Incorporated into Biocomposites Using Thermocompression

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