Evaluation of affective temperaments and arterial stiffness in different hypertension phenotypes

Kőrösi, Beáta; Gyöngyösi, Helga; Batta, Dóra; Acsády, László; Kovács, Illés; Tislér, András; Cseprekál, Orsolya; Nemcsik-Bencze, Zsófia; Gonda, Xénia; Rihmer, Zoltán; Nemcsik, János

doi:10.1038/s41440-020-0513-2

Cited by 16 publications

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“…Our results are in line with our recent findings on the same cohort, where cyclothymic affective temperament points were similarly higher in white-coat and resistant hypertension compared with healthy controls and cyclothymic affective temperament points equal or above 6 were independently associated both with white-coat and resistant hypertension [ 14 ]. Therefore, in addition to cyclothymic affective temperament, another psychopathological similarities, namely, the level of depression and anxiety, are also present between white-coat and resistant hypertensive patients.…”

Section: Discussionsupporting

confidence: 93%

“…Anxiety was found to be associated with white-coat effect during blood pressure measurement [ 11 , 12 ], while resistant hypertension was also associated with anxiety [ 13 ]. Recently we described similarities in affective temperament patterns between WhHT and ResHT [ 14 ]. However, until now the level of depression and anxiety was not evaluated in a cohort of individuals with different hypertension phenotypes.…”

Section: Introductionmentioning

confidence: 99%

“…Our present results are part of an additional analysis of a previously published cohort [ 14 ], including the results of the depression and anxiety questionnaires.…”

Section: Introductionmentioning

confidence: 99%

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Depression and anxiety in different hypertension phenotypes: a cross-sectional study

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Background Hypertension is a major risk factor of cardiovascular mortality. Mood disorders represent a growing public health problem worldwide. A complex relationship is present between mood disorders and cardiovascular diseases. However, less data is available about the level of depression and anxiety in different hypertension phenotypes. The aim of our study was to evaluate psychometric parameters in healthy controls (Cont), in patients with white-coat hypertension (WhHT), with chronic, non-resistant hypertension (non-ResHT), and with chronic, treatment-resistant hypertension (ResHT). Methods In a cross-sectional study setup 363 patients were included with the following distribution: 82 Cont, 44 WhHT, 200 non-ResHT and 37 ResHT. The patients completed the Beck Depression Inventory (BDI) and the Hamilton Anxiety Scale (HAM-A). Results BDI points were higher in WhHT (7 (3–11)) and ResHT (6 (3–11.5)) compared with Cont (3 (1–6), p < 0.05). Similarly, HAM-A points were higher in WhHT (8 (5–15)) and ResHT (10.5 (5.25–18.75)) compared with Cont (4 (1–7), p < 0.05) and also compared with non-ResHT (5 (2–10), p < 0.05). ResHT was independently associated with HAM-A scale equal or above 3 points (Beta = 3.804, 95%CI 1.204–12.015). WhHT was independently associated with HAM-A scale equal or above 2 points (Beta = 7.701, 95%CI 1.165–18.973) and BDI scale equal or above 5 points (Beta = 2.888, 95%CI 1.170–7.126). Conclusions Our results suggest psychopathological similarities between white-coat hypertension and resistant hypertension. As recently it was demonstrated that white-coat hypertension is not a benign condition, our findings can have relevance for future interventional purposes to improve the outcome of these patients.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Depression and anxiety in different hypertension phenotypes: a cross-sectional study

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“…Resistant hypertension was defined as blood pressure that remains above 140/90 mmHg in the office despite the concurrent use of three antihypertensive agents of different classes including a diuretic, or as controlled blood pressure with the use of more than three medications [9]. Some results have been published previously from this cohort [10][11][12][13]. An auto-questionnaire, containing data of personal and family medical history, managed during the screening visit, was completed by the subjects.…”

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confidence: 99%

Comparison of Different Cardiovascular Risk Score and Pulse Wave Velocity-Based Methods for Vascular Age Calculation

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et al. 2021

Heart, Lung and Circulation

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“…A szorongó temperamentumúak gyakran félnek a szerencsétlenségektől, jellemzi őket a relaxációra való képtelenség [9,10]. Korábbi vizsgálataink a hypertoniának elsősorban a cyclothym temperamentummal való kapcsolatát igazolták, de az ingerlékeny és a hyperthym temperamentummal is feltételezhető volt összefüggés [5,11,12].…”

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Az affektív temperamentumok és az artériás érfalmerevségi index kapcsolata krónikus hypertoniás betegekben

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Összefoglaló. Bevezetés: Az affektív temperamentumok (depresszív, cyclothym, hyperthym, ingerlékeny, szorongó) a személyiségnek olyan genetikailag meghatározott, felnőttkorban stabil részei, amelyekkel jellemezhetők a környezeti ingerekre adott érzelmi válaszok. Az artériás érfalmerevségi index megmutatja, hogy az adott egyénnek a valóságban mért és az elvárt pulzushullám-terjedési sebessége (PWV) milyen arányban áll egymással; pozitív értéke számít kórosnak. Célkitűzés: Célunk az volt, hogy az affektív temperamentumok kapcsolatát vizsgáljuk az artériás érfalmerevségi indexszel krónikus hypertoniás betegekben. Módszer: A bevont betegeknél tonometriás eszközzel (PulsePen) mértük a carotis–femoralis PWV-t, mely az artériás érfalmerevség legelfogadottabb markere. Az artériás érfalmerevségi indexet a mért és az elvárt PWV arányában határoztuk meg. Az affektív temperamentumokat a Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire kérdőív (TEMPS-A) segítségével objektivizáltuk. Eredmények: Vizsgálatunkba 185 beteget vontunk be, életkoruk 61,6 (49,5–69,8) év volt. Kortól, nemtől, diabetestől, alkoholfogyasztástól, dohányzástól, BMI-től, systolés vérnyomástól, összkoleszterinszinttől és GFR-től független kapcsolatot találtunk az artériás érfalmerevségi index és a depresszív (B = 0,009, 95% CI: 0,002–0,017, p = 0,018), a cyclothym (B = 0,009, 95% CI: 0,002–0,016, p = 0,012), az ingerlékeny (B = 0,013, 95% CI: 0,005–0,021, p<0,001) és a szorongó (B = 0,008, 95% CI: 0,003–0,013, p<0,001) temperamentum között. Következtetés: Újabb kapcsolatot sikerült kimutatni egy cardiovascularis rizikót jelző paraméter és az affektív temperamentumok között, ami megerősíti ezen személyiségjegyek meghatározásának jelentőségét cardiovascularis prevenciós szempontból is az ismert pszichopatológiai vonatkozások mellett. Orv Hetil. 2022; 163(8): 312–318. Summary. Introduction: Affective temperaments (depressive, anxious, cyclothymic, hyperthymic, irritable) are genetically determined, adult-stable parts of the personality that characterize emotional responses to environmental stimuli. The arterial stiffness index demonstrates the ratio of the actually measured and expected pulse wave velocity (PWV) of a given individual. The positive value is considered to be abnormal. Objective: The aim of this study was to investigate the relationship between affective temperaments and arterial stiffness index in chronic hypertensive patients. Method: Carotid-femoral PWV, the most accepted marker of arterial stiffness, was measured using a tonometric device (PulsePen). The arterial stiffness index was determined as the ratio of measured and expected PWVs. Affective temperaments were evaluated by the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A). Results: The study included 185 patients, with a mean age of 61.6 (49.5–69.8) years. We found association between arterial stiffness index and depressive (B = 0.009, 95% CI: 0.009–0.017, p = 0.018), cyclothymic (B = 0.009, 95% CI: 0.002–0.016, p = 0.012), irritable (B = 0.013, 95% CI: 0.005–0.021, p = 0.001), and anxious (B = 0.008, 95% CI: 0.003–0.013, p = 0.001) temperaments independent of age, sex, diabetes, alcohol consumption, smoking, BMI, systolic blood pressure, total cholesterol, and GFR. Conclusion: An additional relationship between a cardiovascular risk measure and affective temperaments has been demonstrated, confirming the importance of determining these personality traits aiming cardiovascular prevention in addition to their known psychopathological aspects. Orv Hetil. 2022; 163(8): 312–318.

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Evaluation of affective temperaments and arterial stiffness in different hypertension phenotypes

Cited by 16 publications

References 39 publications

Depression and anxiety in different hypertension phenotypes: a cross-sectional study

Depression and anxiety in different hypertension phenotypes: a cross-sectional study

Comparison of Different Cardiovascular Risk Score and Pulse Wave Velocity-Based Methods for Vascular Age Calculation

Az affektív temperamentumok és az artériás érfalmerevségi index kapcsolata krónikus hypertoniás betegekben

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