Evaluation of Aloe Vera Leaf Extracts and Aloe Emodin on Several Cancer Cell Lines

Akev, Nuriye

doi:10.31925/farmacia.2020.6.24

Cited by 5 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These differences between the previous results and the current study's results could be due to different types of extraction. As shown in the results, the cytotoxic effect of AVG was the most, but the best result was achieved with a 50 µL concentration (42). It seems that only the AVG with the concentrations (5,10,15,20) we used in this study could not demonstrate cytotoxic effects, as the present study did not show any cytotoxic effect.…”

Section: Discussionsupporting

confidence: 44%

The Role of Aloe vera in Inhibiting the P53 Protein Expression and Enhancing the HT29 Colon Cancer Cells Proliferation

Hesari,

Shafaei,

Khamnei

et al. 2023

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background: Aloe vera is one of the most widely recognized herbs considered a valid treatment option for its wound healing and anti-inflammatory properties. However, there is insufficient evidence regarding the effectiveness of its anti-tumor activity on colon cancer. Objectives: In this study, therefore, we investigated the effect of Aloe vera on the proliferation and survival of the HT29 colon cancer cell line. Methods: The effect of processed Aloe vera gel (PAG) on colon carcinogenesis was examined using low glucose Dulbecco’s modified Eagle’s medium (DMEM) with 10% serum and 1% penicillin-streptomycin in the HT29 cells. Then, we obtained the expression levels of P53 and BCL2 using the immunocytochemical (ICC) method. To determine the viability of the HT29 cells, we also performed the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: The MTT assay showed that the HT29 cells were viable in 5%, 10%, 15%, and 20% of Aloe vera gel (AVG). However, these cells had a more obvious proliferation in the 10% Aloe vera group than in the control group. In the 10% concentration group, mitotic cells were evident in the center of the colonies. The P53 protein expression decreased, but the BCL2 protein expression remained unchanged in the 10% group compared to the control group. Conclusions: The results, therefore, indicated that in the 10% Aloe vera concentration, the expression levels of P53, known as a tumor suppressor protein in colon cancer, decreased in HT29. Our results also showed that the application of Aloe vera for its anti-tumor activity in colon cancer should be further evaluated.

show abstract

Section: Discussionsupporting

confidence: 44%

The Role of Aloe vera in Inhibiting the P53 Protein Expression and Enhancing the HT29 Colon Cancer Cells Proliferation

Hesari,

Shafaei,

Khamnei

et al. 2023

Zahedan J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…Natural anticancer alternatives can have a direct effect on malignant cells, as well as by stimulating the body's immune capacity in the fight against the aggression of carcinogenic factors, internal or external [78,79]. The favourable effects of some medicinal plants are due to the main biochemical components: flavonoids-which inhibit the activity of carcinogens and prevent the metastasis of malignant cells; carotenoids-which protect the body against colon cancer; terpenes in essential oils-block the action of carcinogens, having a strong antioxidant action; β-carotene, a powerful antioxidant with anticancer protection and a recognized inhibitor of malignant cells; antioxidant vitamins C, E, and A, destroy free radicals, prevent cancer, and block the metastasis process [80][81][82][83].…”

Section: Cytotoxic and Anticancer Effectsmentioning

confidence: 99%

A Literature‐Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles

Islam

Quispe

El‐Kersh

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Benincasa hispida (Thunb.) Cogn. (Cucurbitaceae) is an annual climbing plant, native to Asia with multiple therapeutic uses in traditional medicine. This updated review is aimed at discussing the ethnopharmacological, phytochemical, pharmacological properties, and molecular mechanisms highlighted in preclinical experimental studies and toxicological safety to evaluate the therapeutic potential of this genus. The literature from PubMed, Google Scholar, Elsevier, Springer, Science Direct, and database was analyzed using the basic keyword “Benincasa hispida.” Other searching strategies, including online resources, books, and journals, were used. The taxonomy of the plant has been made by consulting “The Plant List”. The results showed that B. hispida has been used in traditional medicine to treat neurological diseases, kidney disease, fever, and cough accompanied by thick mucus and to fight intestinal worms. The main bioactive compounds contained in Benincasa hispida have cytotoxic, anti-inflammatory, and anticancer properties. Further safety and efficacy investigations are needed to confirm these beneficial therapeutic effects and also future human clinical studies.

show abstract

“…have a greater binding affinity toward estrogen alpha receptor as compared to standard drug Tamoxifen (−6.4 Kcal/mol). AKEV, et al (2020) in this study the Fresh leaf skin aqueous and methanolic extracts, as well as shade-dried leaf skin methanolic extracts prepared separately from the leaves of Aloe vera and Aloe-emodin (AE), were assayed on human gastric (AGS), colon (HT-29, HCT116) and hepatocellular (HEPG2) cancer cell lines relative to human umbilical vein endothelial cells (HUVEC). AE, 5-fluorouracil (5-FU), and imatinib (IM) were tested as positive controls.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Rehman, et al (2017) Bioassay-guided fractionation of Aloe vera resulted in the isolation and characterization of one new C-glucosyl chromone, 7-methoxy6′-O-coumaroylAloesin (1), along with the known dihydroisocoumarin feralolide (2). The structure of 1 was elucidated based on 1D, 2D-NMR, and mass spectrometry.…”

Section: Literature Reviewmentioning

confidence: 99%

Literature review of Aloe vera cytotoxicity

Al-Wajih¹,

El-Shaibany²,

Raweh³

et al. 2022

GSC Biol. Pharm. Sci.

View full text Add to dashboard Cite

Aloe vera juice enables the body to heal from cancer and from the damage caused by radio and chemotherapy that destroys healthy immune cells crucial for recovery. Aloe vera emodin, an anthraquinone, can suppress or inhibit the growth of cancer cells making it have antineoplastic properties. The role of Aloe in carcinogenicity has not been evaluated well. The chronic abuse of Anthracoid-containing laxatives has been hypothesized to play a role in colorectal cancer. Aloe vera tincture and melatonin administration were studied as standard therapy against metastatic solid tumors. (c, 2016 For thousands of years, plants are an important source of medicine in pharmaceutical biology. As per WHO, 80% of the population today relies on traditional medicine.

show abstract

Evaluation of Aloe Vera Leaf Extracts and Aloe Emodin on Several Cancer Cell Lines

Cited by 5 publications

References 28 publications

The Role of Aloe vera in Inhibiting the P53 Protein Expression and Enhancing the HT29 Colon Cancer Cells Proliferation

The Role of Aloe vera in Inhibiting the P53 Protein Expression and Enhancing the HT29 Colon Cancer Cells Proliferation

A Literature‐Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles

Literature review of Aloe vera cytotoxicity

Contact Info

Product

Resources

About