2022
DOI: 10.3390/jcm11113139
|View full text |Cite
|
Sign up to set email alerts
|

Evaluation of Alpha-Synuclein Cerebrospinal Fluid Levels in Several Neurological Disorders

Abstract: (1) Background: Alpha-synuclein (α-syn) is a presynaptic neuronal protein that regulates several neuronal functions. In recent decades, the role of α-syn as a biomarker of neurodegenerative diseases has been explored, especially in synucleinopathies. However, only a few studies have assessed its role as biomarker in other neurological disorders. The aim of the study was to evaluate cerebrospinal fluid (CSF) α-syn levels in several neurological disorders; (2) Methods: We measured CSF α-syn levels by a commercia… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 7 publications
(1 citation statement)
references
References 43 publications
0
1
0
Order By: Relevance
“…The research in the field of ALS biomarkers is hampered by several factors, including the rarity of the disease, the delayed diagnosis, and the high rate of misdiagnosis. While improvements in biotechnology have led to significant progress for several neurological diseases, such as Alzheimer's disease [39][40][41], the biomarker discovery of ALS is strongly slowed down. In the last decades, TDP-43 has gained attention, and preliminary data are promising.…”
Section: Discussionmentioning
confidence: 99%
“…The research in the field of ALS biomarkers is hampered by several factors, including the rarity of the disease, the delayed diagnosis, and the high rate of misdiagnosis. While improvements in biotechnology have led to significant progress for several neurological diseases, such as Alzheimer's disease [39][40][41], the biomarker discovery of ALS is strongly slowed down. In the last decades, TDP-43 has gained attention, and preliminary data are promising.…”
Section: Discussionmentioning
confidence: 99%