Evaluation of ameliorative potential of selenium on carbendazim induced oxidative stress in male goats

Daundkar, Prashant S.; Rampal, Satyavan

doi:10.1016/j.etap.2014.09.007

Cited by 15 publications

(14 citation statements)

References 53 publications

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“…[ 28 ] Our results align with those of Owumi et al, [ 29 ] who confirmed that orally administered CBZ increased liver function biomarkers levels in rats. To some extent, our findings were also similar to those of Daundkar and Rampal, [ 30 ] who proved that CBZ could alter hepatorenal functions in male goats. Additionally, the liver function biomarkers results were confirmed by the histopathological examination, which demonstrated extensive hepatocellular degeneration and necrosis with portal inflammation and fibrosis.…”

Section: Discussionsupporting

confidence: 91%

Novel insights into the potential mechanisms underlying carbendazim‐induced hepatorenal toxicity in rats

Ebedy

El-Shazly

Hassan

et al. 2022

J Biochem & Molecular Tox

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Carbendazim (CBZ) is a common environmental pollutant that can contaminate food and water and severely damage human health. Some studies revealed the adverse effect of CBZ on different organs, but its detailed toxicity mechanism has not been elucidated yet. Thus, the present study aims to clarify the mechanisms of CBZinduced hepatorenal toxicity in rats. Therefore, we partitioned 40 male Wistar rats into four groups (n = 10): a negative control group and three treatment groups, which received 100, 300, and 600 mg/kg of CBZ. All rats received the treatment daily by oral gavage. We collected blood and organ samples (liver and kidney) at 14 and 28 days postdosing. CBZ caused extensive pathological alterations in both the liver and kidneys, such as cellular degeneration and necrosis accompanied by severe inflammatory reactions in a dose-and time-dependent manner. All the CBZ-treated groups displayed strong tumor necrosis factor-α and nuclear factor-κB (NF-κB) immunopositivity. Additionally, CBZ dose-dependently elevated the alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, urea, and creatinine serum levels and reduced the serum albumin levels. Furthermore, CBZ-induced apoptosis, as indicated by the observed Bax gene upregulation and Bcl-2 gene downregulation in both organs. All these changes may be related to oxidative stress, as indicated by the increase in malondialdehyde levels and the decrease in total antioxidant capacity. Our results demonstrate that CBZ-induced dose-and time-dependent hepatorenal damage through oxidative stress, which activated both the NF-κB signaling pathway and Bcl-based programmed cell death.

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Section: Discussionsupporting

confidence: 91%

Novel insights into the potential mechanisms underlying carbendazim‐induced hepatorenal toxicity in rats

Ebedy

El-Shazly

Hassan

et al. 2022

J Biochem & Molecular Tox

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“…Prashantkumar et al found that exposure to CBZ in male goats caused testicular damage and impaired liver, kidney and blood function [3]. Meanwhile, the study found that CBZ can change the antioxidant defense system [4]. Hence, in the field of food safety, CBZ is restricted in different countries and foods.…”

Section: Introductionmentioning

confidence: 99%

An Improved POD Model for Fast Semi-Quantitative Analysis of Carbendazim in Fruit by Surface Enhanced Raman Spectroscopy

Yang

Lin

et al. 2022

Molecules

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The current detection method of carbendazim suffers from the disadvantages of complicated preprocessing and long cycle time. In order to solve the problem of rapid quantitative screening of finite contaminants, this article proposed a qualitative method based on characteristic peaks and a semi-quantitative method based on threshold to detect carbendazim in apple, and finally the method is evaluated by a validation system based on binary output. The results showed that the detection limit for carbendazim was 0.5 mg/kg, and the detection probability was 100% when the concentration was no less than 1 mg/kg. The semi-quantitative analysis method had a false positive rate of 0% and 5% at 0.5 mg/kg and 2.5 mg/kg, respectively. The results of method evaluation showed that when the added concentration was greater than 2.5 mg/kg, the qualitative detection method was consistent with the reference method. When the concentration was no less than 5 mg/kg, the semi-quantitative method is consistent between different labs. The semi-quantitative method proposed in this study can achieve the screening of finite contaminants in blind samples and simplify the test validation process through the detection probability model, which can meet the needs of rapid on-site detection and has a good application prospect.

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“…In fact, CBZ has been related to major human diseases, such as cancer, and is known to produce embryotoxicity, germ cell apoptosis, teratogenesis, infertility, hepatocellular dysfunction, hematopoiesis, and developmental toxicity in different mammalian species . Besides, CBZ was reported to affect the reproductive functions in hamsters and Japanese quails, and has been found to cause testicular damage and disrupt the biochemical, hepatic, renal, and hematological functions in male goats …”

Section: Introductionmentioning

confidence: 99%

“…8 Besides, CBZ was reported to affect the reproductive functions in hamsters and Japanese quails, and has been found to cause testicular damage and disrupt the biochemical, hepatic, renal, and hematological functions in male goats. 9 CBZ is a degradation product of benomyl and thiophanatemethyl, which are also fungicides commonly used in agriculture. 10 Depending on the nature of the environment, residual CBZ has a half-life of about 3 days to 12 months.…”

Section: Introductionmentioning

confidence: 99%

Chromatographic Methods for Detection and Quantification of Carbendazim in Food

Wang

Shi

Liu

et al. 2020

J. Agric. Food Chem.

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Carbendazim (CBZ), which is a fungicide widely used for the management of plant diseases, has been detected in a number of food products. The negative effects of CBZ to human health have stimulated the reduction of the maximum residue limits (MRLs), and subsequently the development of reliable and sensitive detection methods. Here, we are reviewing for the first time all reported chromatographic methods for the detection and quantification of CBZ in food. Several techniques, including liquid chromatography (LC), thin layer chromatography (TLC), micellar electrokinetic chromatography (MEKC), and supercritical fluid chromatography (SFC), were used for the separation and detection of CBZ, showing diverse characteristics and sensitivity. Some methods allowed the specific determination of CBZ, whereas other methods were successfully applied for the simultaneous quantification of a huge number of pesticides. Most reported methods showed limits of detection (LOD) and quantification (LOQ) lower than the MRLs. Relevant efforts in the field have been directed toward the simplification and optimization of the extraction steps prior to the chromatographic separation to increase the recovery and reduce the matrix effects. In this Review, the matrices, extraction procedures, and separation and detection parameters are detailed and compared in order to provide new insights on the development of new reliable methods for the detection of CBZ in food.

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Evaluation of ameliorative potential of selenium on carbendazim induced oxidative stress in male goats

Cited by 15 publications

References 53 publications

Novel insights into the potential mechanisms underlying carbendazim‐induced hepatorenal toxicity in rats

Novel insights into the potential mechanisms underlying carbendazim‐induced hepatorenal toxicity in rats

An Improved POD Model for Fast Semi-Quantitative Analysis of Carbendazim in Fruit by Surface Enhanced Raman Spectroscopy

Chromatographic Methods for Detection and Quantification of Carbendazim in Food

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