Evaluation of an accelerated hydrogen peroxide disinfectant to inactivate porcine epidemic diarrhea virus in swine feces on aluminum surfaces under freezing conditions

Baker, Kimberlee L.; Thomas, Paul R.; Karriker, Locke A.; Ramirez, Alejandro; Zhang, Jianqiang; Wang, Chong; Holtkamp, Derald

doi:10.1186/s12917-017-1300-4

Cited by 17 publications

(16 citation statements)

References 13 publications

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“…Accelerated hydrogen peroxide formulations have been assessed for 229E and PEDV. 121,157,158 In full strength exposure with one formulation, greater than 4log 10 reduction in 229E was achieved at 20°C for 1 minute in the presence of 5% serum. Virus-product exposure required Sephadex neutralization.…”

Section: Peroxidesmentioning

confidence: 99%

“…121 For PEDV and with a similar product, 1:16 and 1:32 dilutions have been assessed to inactivate virus. 157,158 Major reductions in titer have been observed for virus-laden feces. After exposure for 40 to 60 minutes, pig inoculation bioassays confirmed lack of infectivity.…”

Section: Peroxidesmentioning

confidence: 99%

“…The pH of the product was ~3, and surfactants had also been included 121 . For PEDV and with a similar product, 1:16 and 1:32 dilutions have been assessed to inactivate virus 157,158 . Major reductions in titer have been observed for virus‐laden feces.…”

Section: Decontamination Of Coronavirusesmentioning

confidence: 99%

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Environmental and decontamination issues for human coronaviruses and their potential surrogates

Cimolai

2020

Journal of Medical Virology

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Pandemic coronavirus disease-2019 (COVID-19) gives ample reason to generally review coronavirus (CoV) containment. For establishing some preliminary views on decontamination and disinfection, surrogate CoVs have commonly been assessed. This review serves to examine the existing science in regard to CoV containment generically and then to translate these findings into timely applications for COVID-19. There is widespread dissemination of CoVs in the immediate patient environment, and CoVs can potentially be spread via respiratory secretions, urine, and stool. Interpretations of the spread however must consider whether studies examine for viral RNA, virus viability by culture, or both. Presymptomatic, asymptomatic, and post-14 day virus excretion from patients may complicate the epidemiology. Whereas droplet spread is accepted, there continues to be controversy over the extent of possible airborne spread and especially now for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). CoVs are stable in body secretions and sewage at reduced temperatures. In addition to temperature, dryness or relative humidity, initial viral burden, concomitant presence of bioburden, and the type of surface can all affect stability. Generalizing, CoVs can be susceptible to radiation, temperature extremes, pH extremes, peroxides, halogens, aldehydes, many solvents, and several alcohols. Whereas detergent surfactants can have some direct activity, these agents are better used as complements to a complex disinfectant solution. Disinfectants with multiple agents and adverse pH are more likely to be best active at higher water temperatures. Real-life assessments should be encouraged with working dilutions. The use of decontamination and disinfection should be balanced with considerations of patient and caregiver safety. Processes should also be balanced with considerations for other potential pathogens that must be targeted. Given some CoV differences and given that surrogate testing provides experimental correlates at best, direct assessments with SARS-CoV, Middle East respiratory syndrome-related coronavirus (MERS-CoV), and SARS-CoV-2 are required.

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Section: Peroxidesmentioning

confidence: 99%

Section: Peroxidesmentioning

confidence: 99%

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Environmental and decontamination issues for human coronaviruses and their potential surrogates

Cimolai

2020

Journal of Medical Virology

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“… 63 In another report, it demonstrates that disinfecting solutions as hydrogen peroxide decreased the viral particles of the porcine epidemic diarrhea virus. 64 The hydrogen peroxide, a coadjutant substance in contact lenses cleaning, it has been effectively performed in a rigid and soft contact lenses. 58 Hence, it is possible to think that in pandemic time, the interaction of disinfecting agent together with multipurpose solution and hand washing should minimize the infection risk in that population.…”

Section: Contact Lenses and Sars-cov-2mentioning

confidence: 99%

The eye: “An organ that must not be forgotten in coronavirus disease 2019 (COVID-2019) pandemic”

2021

Journal of Optometry

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The coronavirus family is a group of zoonotic viruses with some recognized reservoirs particularly some bats. A novel coronavirus emerged in the province of Wuhan (China) in December of 2019.The number of infected patient with serious respiratory infection quickly spread around the world to become a global pandemic. The clinical presentation and viral pathogenesis of the coronavirus disease named COVID-19 indicated that the virus is transmitted from person to person through infected droplets entering the respiratory mucosa. Close contact with infected individuals particularly in crowded environments has characterized the rapid spread of the infection. Clinical manifestations of the viral infection have mentioned the presence of some ocular findings such as conjunctival congestion, conjunctivitis and even corneal injury associated with the classical COVID-19 infection. Some animal models of different coronaviruses eye infections have described the viral pathogenesis through tear and conjunctival sampling. On the other hand, we are recommended protective measure to prevent contagion and limit the spread of the virus in health care professionals and contact lenses wearers.

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“…Вдало застосовують розчини формаліну з вмістом 1,5% формальдегіду, розчин нейтрального гіпохлориду кальцію з вмістом 5,0% активного хлору, 5,0% розчин хлораміну, хлорне вапно, з вмістом не менш як 25,0% активного хлору, перекис водню, однохлористого йоду, йодозоль, йодис, 3,0% гарячий розчин їдкого натру та ін. (Gerber et al, 2014;Bowman et al, 2015;Quist-rybachuk et al, 2015;Tun et al, 2016;Baker et al, 2017;Holtkamp et al, 2017;Martelli et al, 2017;.…”

Section: вступunclassified

Evaluation of the cleansing and disinfection protocol of pig-breeding premises contaminated by the porcine epidemic diarrhea virus

et al. 2018

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The results of the determination of the efficiency of the cleaning and disinfection protocol of pig farms contaminated by the porcine epidemic diarrhea virus are presented in this study. The research was conducted in the Scientific Research Center of Biosafety and Environmental Control AIC of the Dnipro State Agrarian and Economic University. The experimental part was carried out on the basis of a permanently infected pig breeding farm of the southern region of Ukraine. In order to determine the critical points, a selection of samples of washings/scraps from the surfaces of the pig farm’s premises and the objects of the environment was carried out before cleaning and disinfection and after 1 and 2 premises’ sanitation. A total of 204 tests were analyzed. Disinfection of the territory of pig farms and livestock premises was carried out in accordance with generally accepted methods. Before disinfection, a thorough mechanical cleaning of livestock premises was carried out, with subsequent irrigation of all surfaces with cold tap water. Disinfection of premises and the territory of the pig complex was carried out by the wet cleaning of surfaces with a solution of disinfectant based on glutaraldehyde after preparatory operations in the absence of animals. After disinfection the premises were additionally processed with Ca(OH)2 solution. Washes were obtained with a sterile swab from a surface of 10.0 cm2 by inserting a swab into a test tube with a sterile physiological solution. Scraps from the surfaces were obtained with a disposable sterile blades from the scalpel. The obtained material was placed in disposable sterile plastic 1.5–2.0 cm3 test tubes. The study of the presence of the PEDV was performed using a real-time polymerase chain reaction with the previous reverse transcription of RNA. It was established that the causative agent of PED in a permanently infected farm contaminates most of the production and auxiliary premises and objects of the environment. The one-time cleaning and disinfection protocol does not allow free the farm from the PEDV completely. Only two-time sanitation of premises and objects of the environment with the laboratory control of the efficiency of cleaning and disinfection contributes to the effective eradication of the PEDV.

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Evaluation of an accelerated hydrogen peroxide disinfectant to inactivate porcine epidemic diarrhea virus in swine feces on aluminum surfaces under freezing conditions

Cited by 17 publications

References 13 publications

Environmental and decontamination issues for human coronaviruses and their potential surrogates

Environmental and decontamination issues for human coronaviruses and their potential surrogates

The eye: “An organ that must not be forgotten in coronavirus disease 2019 (COVID-2019) pandemic”

Evaluation of the cleansing and disinfection protocol of pig-breeding premises contaminated by the porcine epidemic diarrhea virus

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