Evaluation of an edible polyherbal formulation against urinary tract infection pathogens, its antioxidant and anti-inflammatory potential

Abbas, Zuvairiya; Manoharan, Ashwini Lydia; Jagadeesan, Gayathri; Nataraj, Gayathri; Muniyandi, Kasipandi; Sathyanarayanan, Saikumar; Thangaraj, Parimelazhagan

doi:10.1016/j.bcab.2021.102104

Cited by 12 publications

(16 citation statements)

References 34 publications

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“…Among phenolic acids, the presence of a 3-hydroxyl structure (2,3-hydroxybenzoic acid, gallic acid, caffeic acid, and caftaric acid) suppresses the production of reactive oxygen species and enhances the antioxidant effects . The present results are in line with the findings of Abbas et al who investigated that edible polyherbal formulations had the highest total phenolic content (346.88 ± 30.53 mg GAE/g) . The TPC values presented here are also similar to the results reported by (Iftikhar et al) on a polyherbal formulation consisting of selected medicinal plant extracts …”

Section: Resultssupporting

confidence: 93%

“…24 The present results are in line with the findings of Abbas et al who investigated that edible polyherbal formulations had the highest total phenolic content (346.88 ± 30.53 mg GAE/g). 25 The TPC values presented here are also similar to the results reported by (Iftikhar et al) on a polyherbal formulation consisting of selected medicinal plant extracts. 26 The amount of TFC in different formulations is given in Figure 2.…”

Section: )mentioning

confidence: 99%

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Antioxidant, Hypoglycemic, Antilipidemic, and Protective Effect of Polyherbal Emulsion (F6-SMONSECCE) on Alloxan-Induced Diabetic Rats

Akhtar,

Almas,

Safdar

et al. 2023

ACS Omega

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The current study focused on the antioxidant potential, α-amylase inhibitory activity, and hypoglycemic, hypolipidemic, and histoprotective (pancreas and kidney) effects of polyherbal emulsion on the alloxan-induced diabetic rats. Polyherbal formulations were prepared from extracts and oils of Nigella sativa (N. sativa), Citrullus colocynthis (C. colocynthis), and Silybum marianum (S. marianum). Out of nine stable formulations, one formulation named F6-SMONSECCE was found to be the best after its evaluation using antioxidant and in vitro α-amylase inhibition assay. The prepared herbal formulations showed significant (p < 0.05) antioxidant activity in terms of radical scavenging as 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferricreducing antioxidant power (FRAP) assays and also revealed the presence of a significant amount of total phenolic and flavonoid contents. "F6-SMONSECCE" (prepared with composition; Silybum marianum oil (SMO) + Nigella sativa extract (NSE) + Citrullus colocynthis extract CCE) was selected for an in vivo trial to ascertain its antidiabetic potential. The treatment dose was determined by using an acute toxicity trial on rats. Administration of alloxan (150 mg/kg b.w., i.p.) significantly (P < 0.05) augmented the blood glucose levels and lipid contents as total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL-c), and very-low-density lipoproteins (VLDL-c). However, the levels of insulin and high-density lipoproteins (HDL-c) were found to be decreased, and the histopathological alterations were also found in the pancreas and kidney. The administration of the polyherbal formulation (F6-SMONSECCE) significantly attenuated the blood glucose levels (22.94%), TC (29.10%), TG (38.15%), LDL-c (27.58%), and VLDL-c (71.52%), whereas on the other side, the insulin (−149.15%) and HDL-c levels (−22.22%) were significantly increased. A significant histopathological normalization was observed in the pancreas and kidney tissues of the F6-SMONSECCE-treated rats. The current findings proposed that the prepared polyherbal formulation "F6-SMONSECCE" exhibited significant antioxidant, antilipidemic, and hypoglycemic potential and hence might be suggested as a remedy against diabetes or as a coadjuvant to synthetic medicines to maintain normal physiology.

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Section: Resultssupporting

confidence: 93%

Section: )mentioning

confidence: 99%

Antioxidant, Hypoglycemic, Antilipidemic, and Protective Effect of Polyherbal Emulsion (F6-SMONSECCE) on Alloxan-Induced Diabetic Rats

Akhtar,

Almas,

Safdar

et al. 2023

ACS Omega

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“…Total protein content of extracts was estimated by the Lowry method with some modifications [ 70 ]. BSA was used as a standard.…”

Section: Methodsmentioning

confidence: 99%

Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

Khantham

Linsaenkart

Chaitep

et al. 2022

Plants

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Androgenetic alopecia (AGA), a hair loss disorder, is a genetic predisposition to sensitive androgens, inflammation, and oxidative stress. Unfortunately, current treatments with synthetic medicines contain a restricted mechanism along with side effects, whereas the bioactive constituents of plant extracts are multifunctional, with fewer side effects. The massive amounts of rice husk and bran are agricultural wastes that may cause pollution and environmental problems. Owing to these rationales, the local rice variety, Bue Bang 3 CMU (BB3CMU), which is grown in northern Thailand, was evaluated for the valuable utilization of rice by-products, husk (BB3CMU-H) and bran (BB3CMU-RB) extracts, for AGA treatment regarding antioxidant, anti-inflammatory, anti-androgenic activities, and the characterization of bioactive compounds. Our study verified that BB3CMU-H had the highest level of polyphenols, contributing to its greater antioxidant activity. Conversely, BB3CMU-RB was the predominant source of tocopherols, resulting in better anti-androgenic activities regarding the downregulation of steroid 5α-reductase genes (SRD5A). Notably, anti-inflammation via the attenuation of nitric oxide productions was observed in BB3CMU-H (0.06 ± 0.13 μM) and BB3CMU-RB (0.13 ± 0.01 μM), which were significantly comparable to diclofenac sodium salt (0.13 ± 0.19 μM). Therefore, the combination of BB3CMU-H and BB3CMU-RB could be utilized in cosmeceutical and pharmaceutical applications for AGA patients.

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“…The results indicated a different pattern of antioxidant activity, particularly at the gap between the low and high potential antioxidant profiles. As discussed above, the antioxidant properties of single-component and poly-combination were affected by the biological activity and interaction of components in the extract (Abbas et al 2021). The interaction between C. longa and C. asiatica showed the synergistic effect through interaction between primary marker compounds-curcumin and asiaticoside.…”

Section: Discussionmentioning

confidence: 96%

Assessment of the synergistic effect of a poly-herbals combination on the antioxidant activity through a statistical approach

et al. 2022

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Poly-herbals combination was applied to enhance biological activity, particularly antioxidant activity. This present study was purposed to assess the synergistic interaction of a combination of five traditional Indonesian herbal plants through a simultaneous and integrated statistical technique. The plants were extracted using maceration, and purification was conducted before extraction to eliminate the ballast compounds. A simplex lattice design comprising 35 design points was utilized to understand herbal combinations' main effect and interaction through multiple linear regression analysis on the antioxidant activity using DPPH and ABTS assays. The results showed that C. longa, P. niruri, and C. xanthorrhiza had the most potent antioxidant activity than M. oleifera and C. asiatica. The presence of C. longa modulated the synergistic interaction between combinations. Meanwhile, the non-curcuminoid content in C. xanthorrhiza played a fundamental role in reducing the antioxidant activity. The synergistic interaction could enhance the antioxidant activity through poly-herbals combination. In addition, particular consideration should be withdrawn by antagonism interaction in the poly-herbals combination for reducing the biological activity.

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Evaluation of an edible polyherbal formulation against urinary tract infection pathogens, its antioxidant and anti-inflammatory potential

Cited by 12 publications

References 34 publications

Antioxidant, Hypoglycemic, Antilipidemic, and Protective Effect of Polyherbal Emulsion (F6-SMONSECCE) on Alloxan-Induced Diabetic Rats

Antioxidant, Hypoglycemic, Antilipidemic, and Protective Effect of Polyherbal Emulsion (F6-SMONSECCE) on Alloxan-Induced Diabetic Rats

Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

Assessment of the synergistic effect of a poly-herbals combination on the antioxidant activity through a statistical approach

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