Evaluation of an Engineered Hybrid Matrix for Bone Regeneration via Endochondral Ossification

Mikael, Paiyz E.; Golebiowska, Aleksandra; Xin, Xiaonan; Nukavarapu, Syam P.

doi:10.1007/s10439-019-02279-0

Cited by 19 publications

(19 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this polymer-gel hybrid scaffold, the gel phase provides a microenvironment to guide the endochondral process, while the polymer phase is expected to provide mechanical strength to the overall polymer-gel structure. 111 PCL possesses an appropriately high bulk stiffness to facilitate MSC differentiation toward skeletal lineages and has been selected as a scaffold material to support chondrogenesis and hypertrophic mineralization. 112 In addition, bioprinted PCL microfiber networks have been used to reinforce the mechanical strength of engineered cartilaginous templates, which support the development of a vascularized bone organ containing trabecular-like bone and a supporting hematopoietic marrow structure.…”

Section: Engineering Strategies For the In Vitro Recapitulation Of Ecmentioning

confidence: 99%

Bone defect reconstruction via endochondral ossification: A developmental engineering strategy

Liu

Yan

et al. 2021

J Tissue Eng

View full text Add to dashboard Cite

Traditional bone tissue engineering (BTE) strategies induce direct bone-like matrix formation by mimicking the embryological process of intramembranous ossification. However, the clinical translation of these clinical strategies for bone repair is hampered by limited vascularization and poor bone regeneration after implantation in vivo. An alternative strategy for overcoming these drawbacks is engineering cartilaginous constructs by recapitulating the embryonic processes of endochondral ossification (ECO); these constructs have shown a unique ability to survive under hypoxic conditions as well as induce neovascularization and ossification. Such developmentally engineered constructs can act as transient biomimetic templates to facilitate bone regeneration in critical-sized defects. This review introduces the concept and mechanism of developmental BTE, explores the routes of endochondral bone graft engineering, highlights the current state of the art in large bone defect reconstruction via ECO-based strategies, and offers perspectives on the challenges and future directions of translating current knowledge from the bench to the bedside.

show abstract

Section: Engineering Strategies For the In Vitro Recapitulation Of Ecmentioning

confidence: 99%

Bone defect reconstruction via endochondral ossification: A developmental engineering strategy

Liu

Yan

et al. 2021

J Tissue Eng

View full text Add to dashboard Cite

show abstract

“…The biofunctionalized active moieties, such as stem cells and growth factors, on the ceramic scaffolds processed through PBSLP could initiate the immediate formation of an avascular callus of cartilage. The bioactive moieties facilitate the endochondral process [ 161 ], while the porous ceramic scaffold processed through PBSLP provides the necessary mechanical stability needed for the bone defect (load-bearing applications).…”

Section: Synthetic Bioactive Ceramic Scaffolds For Critical Size Bone Defects By Pbslpmentioning

confidence: 99%

Bioactive Ceramic Scaffolds for Bone Tissue Engineering by Powder Bed Selective Laser Processing: A Review

2021

View full text Add to dashboard Cite

The implementation of a powder bed selective laser processing (PBSLP) technique for bioactive ceramics, including selective laser sintering and melting (SLM/SLS), a laser powder bed fusion (L-PBF) approach is far more challenging when compared to its metallic and polymeric counterparts for the fabrication of biomedical materials. Direct PBSLP can offer binder-free fabrication of bioactive scaffolds without involving postprocessing techniques. This review explicitly focuses on the PBSLP technique for bioactive ceramics and encompasses a detailed overview of the PBSLP process and the general requirements and properties of the bioactive scaffolds for bone tissue growth. The bioactive ceramics enclosing calcium phosphate (CaP) and calcium silicates (CS) and their respective composite scaffolds processed through PBSLP are also extensively discussed. This review paper also categorizes the bone regeneration strategies of the bioactive scaffolds processed through PBSLP with the various modes of functionalization through the incorporation of drugs, stem cells, and growth factors to ameliorate critical-sized bone defects based on the fracture site length for personalized medicine.

show abstract

“…The recapitulation of developmental bone growth process was demonstrated in human stromal cell culture and in rat models of bone regeneration, where the macroporous scaffold functioned as a highly aligned biomaterial template that aligns ECM fibers along the bone axis. Alternatively, a synthetic ECM was also proposed as a hybrid between hyaluronan-fibrin and a polymer biodegradable template represented by Poly(Lactic-co-Glycolic Acid) (PLGA) microspheres [37].…”

Section: In Vitro Testing Of Organic Coatings For Tissue Engineeringmentioning

confidence: 99%

Biomimetic Coatings Obtained by Combinatorial Laser Technologies

Axente

Sima

2020

Coatings

View full text Add to dashboard Cite

The modification of implant devices with biocompatible coatings has become necessary as a consequence of premature loosening of prosthesis. This is caused mainly by chronic inflammation or allergies that are triggered by implant wear, production of abrasion particles, and/or release of metallic ions from the implantable device surface. Specific to the implant tissue destination, it could require coatings with specific features in order to provide optimal osseointegration. Pulsed laser deposition (PLD) became a well-known physical vapor deposition technology that has been successfully applied to a large variety of biocompatible inorganic coatings for biomedical prosthetic applications. Matrix assisted pulsed laser evaporation (MAPLE) is a PLD-derived technology used for depositions of thin organic material coatings. In an attempt to surpass solvent related difficulties, when different solvents are used for blending various organic materials, combinatorial MAPLE was proposed to grow thin hybrid coatings, assembled in a gradient of composition. We review herein the evolution of the laser technological process and capabilities of growing thin bio-coatings with emphasis on blended or multilayered biomimetic combinations. These can be used either as implant surfaces with enhanced bioactivity for accelerating orthopedic integration and tissue regeneration or combinatorial bio-platforms for cancer research.

show abstract

Evaluation of an Engineered Hybrid Matrix for Bone Regeneration via Endochondral Ossification

Cited by 19 publications

References 51 publications

Bone defect reconstruction via endochondral ossification: A developmental engineering strategy

Bone defect reconstruction via endochondral ossification: A developmental engineering strategy

Bioactive Ceramic Scaffolds for Bone Tissue Engineering by Powder Bed Selective Laser Processing: A Review

Biomimetic Coatings Obtained by Combinatorial Laser Technologies

Contact Info

Product

Resources

About