Evaluation of an ethnomedicinal combination containing<i>Semecarpus kurzii</i>and<i>Hernandia peltata</i>used for the management of inflammation

Das, Sonali; Mukherjee, Hemanta; Ahmed, Sk Milan; Haldar, Pallab Kanti; Mandal, Asit Baran; Mahapatra, Ambikesh; Chakraborti, Sekhar; Chattopadhyay, Debprasad

doi:10.3109/13880209.2012.762405

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…The ability of ASE to reduce the inflammation induced by carrageenan was possibly due to some phytochemicals that may block the release of any of those mediators. On the other hand, dextran-mediated inflammation was reduced probably as a result of antihistaminic effects of the extract, as dextran can cause inflammation through both histamine and serotonin (Das et al, 2013). The ability of ASE to reduce the oedema volume produced by carrageenan, dextran and histamine suggests that the phytochemicals present in the extract may block the release of any of those mediators, alone or in combination.…”

Section: Discussionmentioning

confidence: 94%

Bioassay directed isolation of a novel anti-inflammatory cerebroside from the leaves of Aerva sanguinolenta

Mandal

Ojha²,

Lalee

et al. 2014

Med Chem Res

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This paper attempts to evaluate the antiinflammatory potential and the possible mechanism of action of the leaf extracts and isolated compound(s) of Aerva sanguinolenta (Amaranthaceae), traditionally used in ailments related to inflammation. The anti-inflammatory activity of ethanol extract (ASE) was evaluated by acute, subacute and chronic models of inflammation, while a new cerebroside ('trans', ASE-1), isolated from the bioactive ASE and characterized spectroscopically, was tested by carrageenan-induced mouse paw oedema and protein exudation model. To understand the underlying mechanism, we measured the release of pro-inflammatory mediators such as nitric oxide (NO) and prostaglandin (PG)E2, along with the cytokines like tumour necrosis factor (TNF)-a, and interleukins(IL)-1b, IL-6 and IL-12 from lipopolysaccharide (LPS)-stimulated peritoneal macrophages. The results revealed that ASE at 400 mg/kg caused significant reduction of rat paw oedema, granuloma and exudative inflammation, while the inhibition of mouse paw oedema and exudative inflammation by ASE-1 (20 mg/kg) was comparable to that of the standard drug indomethacin (10 mg/kg). Interestingly, both ASE and ASE-1 showed significant inhibition of the expressions of iNOS2 and COX-2, and the down-regulation of the expressions of IL-1b, IL-6, IL-12 and TNF-a, in LPS-stimulated macrophages, via the inhibition of COX-2-mediated PGE2 release. Thus, our results validated the traditional use of A. sanguinolenta leaves in inflammation management.

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Section: Discussionmentioning

confidence: 94%

Bioassay directed isolation of a novel anti-inflammatory cerebroside from the leaves of Aerva sanguinolenta

Mandal

Ojha²,

Lalee

et al. 2014

Med Chem Res

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“…Zones of inhibition ranged between 10 and 28 mm at 10% concentration of extract while minimum inhibitory concentration between 0.5% and 2% against tested micro‐organisms. Antiinflammatory activity of extract was assessed by human red blood cell membrane stabilization method in vitro (Das et al ., ), and results showed that a minimum of 50 µg/mL concentration of E. officinalis extract is required to show antiinflammatory effect. Based upon these findings, 10% concentration of E. officinalis extract was finalizedx for subgingival gel application in the present study.…”

Section: Methodsmentioning

confidence: 99%

Effect of Subgingivally Delivered 10% Emblica officinalis Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis - A Randomized Placebo-controlled Clinical Trial

Grover¹,

Tewari²,

Sharma³

et al. 2016

Phytother. Res.

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Emblica officinalis fruit possesses varied medicinal properties including cytoprotective antimicrobial, antioxidant, antiresorptive and antiinflammatory activity. The present study aimed to investigate the effect of subgingival application of indigenously prepared E. officinalis (Amla) sustained-release gel adjunctive to scaling and root planing (SRP) on chronic periodontitis. Forty-six patients (528 sites) were randomly assigned to control group (23;264): SRP +placebo gel and test group (23;264): SRP + 10% E. officinalis gel application. Periodontal parameters: plaque index, gingival index, probing pocket depth (PPD), clinical attachment level (CAL) and modified sulcus bleeding index (mSBI) were assessed at baseline, 2 and 3-month post-therapy. Forty patients (470 sites) completed the trial. When test and control sites were compared, significantly more reduction in mean PPD, mSBI, number of sites with PPD = 5-6 mm, PPD ≥ 7 mm, CAL ≥ 6 mm and greater CAL gain were achieved in test sites at 2- and 3-month post-therapy (p < 0.05). Locally delivered 10% E. officinalis sustained-release gel used as an adjunct to SRP may be more effective in reducing inflammation and periodontal destruction in patients with chronic periodontitis when compared with SRP alone. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Secara tradisional, kulit batang, dahan, dan daunnya digunakan untuk pengobatan malaria, demam, keracunan, dan pereda rasa sakit (Dittmar 1991;Lakshmi et al 2009;Arini & Kinho 2015). Penelitian terkini juga mengungkap berbagai jenis senyawa kimia dari bagian-bagian tumbuhannya yang berpotensi sebagai obat kanker dan tumor (Suthiwong et al 2018;Aimaiti et al 2019), pereda nyeri dan mengurangi peradangan (Das et al 2013;Wei et al 2018). Jenis ini juga memiliki kandungan lemak pada bagian biji yang berpotensi sebagai bahan baku campuran biodiesel (Duyfjes 1996), namun hingga kini belum ada penelitian yang membuktikannya.…”

Section: Pendahuluanunclassified

DISTRIBUSI, EKOLOGI, DAN STATUS KONSERVASI Hernandia nymphaeifolia (C. Presl) Kubitzki DI KALIMANTAN

Sitepu

Atmoko

2020

BKR

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Penelitian distribusi, habitat, dan status konservasi Hernandia nympaheifolia (C. Presl) Kubitzki dilakukan di seluruh wilayah Kalimantan, Indonesia, khususnya pada habitat hutan pantai berpasir. Hasil penelitian menunjukkan jenis ini hidup tersebar di seluruh wilayah Kalimantan, namun tidak selalu ditemukan pada habitat hutan pantai berpasir. Jenis-jenis dominan pembentuk habitat H. nympaheifolia adalah Calophyllum inophyllum, Hibiscus tiliaceus, dan Pongamia pinnata. Tipe tanah pada habitat adalah dominan pasir dengan tingkat kesuburan yang rendah. Berdasarkan hasil survei ditemukan 7 jumlah populasi dan 44 pohon dewasa di Kalimantan. Status konservasi H. nympaheifolia di Indonesia berdasarkan kriteria IUCN termasuk genting /EN (B2b(ii,iii)c(ii,iii).

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Evaluation of an ethnomedicinal combination containingSemecarpus kurziiandHernandia peltataused for the management of inflammation

Cited by 4 publications

References 40 publications

Bioassay directed isolation of a novel anti-inflammatory cerebroside from the leaves of Aerva sanguinolenta

Bioassay directed isolation of a novel anti-inflammatory cerebroside from the leaves of Aerva sanguinolenta

Effect of Subgingivally Delivered 10% Emblica officinalis Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis - A Randomized Placebo-controlled Clinical Trial

DISTRIBUSI, EKOLOGI, DAN STATUS KONSERVASI Hernandia nymphaeifolia (C. Presl) Kubitzki DI KALIMANTAN

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