Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin

Balakrishnan, Biji; Mohanty, Mira; Umashankar, P. R.; Jayakrishnan, A.

doi:10.1016/j.biomaterials.2005.04.012

Cited by 855 publications

(530 citation statements)

References 32 publications

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“…On the basis of the degree of swelling, 3 mm thickness of the hydrogel was optimized for wound dressing. The fluid uptake efficiency of the hydrogel is an important criterion for providing a moist environment over wound bed [22]. Keeping in mind, the PVA was blended with the polyethylene glycol in water alone or aqueous calcium chloride solution.…”

Section: Swelling Study Of Hydrogelsmentioning

confidence: 99%

Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl<SUB>2 </SUB>Hydrogel for Wound Dressing

Dutta¹

2012

CHEMISTRY

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The mixtures of polyvinyl alcohol (PVA) and polyethylene glycol (PEG) with calcium chloride (CaCl 2 ) were exposed to gamma-irradiation to synthesize transparent hydrogels for wound dressing. In this system, CaCl 2 was used not only as a gelling material but also as a plasticizer. The presence of CaCl 2 enhances the effects of PEG, this synergistic effects give births a new hydrogel with improved characteristics. The water absorption capacity of the hydrogel was in the range of 350-375% after immersion in normal saline for 72 h. In vitro weight loss experiments were conducted at 37 o C in order to simulate the use of dressing on wounded skin. The enhanced thermal stability of the hydrogel was confirmed by thermogravimetric analysis (TGA). FTIR studies confirmed the cross-linking between PVA and PEG in the hydrogel. Furthermore, the microbe penetration test of the hydrogel was carried out to confirm its impermeability to bacteria. The effect of hydrogel on cell proliferation was also evaluated to ensure that the hydrogel does not release materials which might be deleterious to cell proliferation. The results showed that the hydrogel could be considered as a potential wound-dressing material.

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Section: Swelling Study Of Hydrogelsmentioning

confidence: 99%

Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl<SUB>2 </SUB>Hydrogel for Wound Dressing

Dutta¹

2012

CHEMISTRY

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“…An ideal wound dressing should control water loss from the wound at an optimal rate, and prevent excessive dehydration as well as build-up of exudates. It has been recommended that a rate of 2000-2500 g/m 2 /day would provide adequate level of moisture without risk of wound dehydration [31]. Lamke et al [32] …”

Section: Resultsmentioning

confidence: 99%

Modifying Fish Gelatin Electrospun Membranes for Biomedical Applications: Cross-Linking and Swelling Behavior

Padrão¹,

Silva²,

Rodrigues³

et al. 2014

Soft Materials

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Development of suitable membranes is a fundamental requisite for tissue and biomedical engineering applications. This work presents fish gelatin random and aligned electrospun membranes cross-linked with glutaraldehyde (GA). It was observed that the fiber average diameter and the morphology is not influenced by the GA exposure time and presents fibers with an average diameter around 250 nm. Moreover, when the gelatin mats are immersed in a phosphate buffered saline solution (PBS), they can retain as much as 12 times its initial weight of solution almost instantaneously, but the material microstructure of the fiber mats changes from the characteristic fibrous to an almost spherical porous structure. Cross-linked gelatin electrospun fiber mats and films showed a water vapor permeability of 1.37 ± 0.02 and 0.13 ± 0.10 (g.mm)/(m 2 .h.kPa), respectively. Finally, the processing technique and cross-linking process does not inhibit MC-3T3-E1 cell adhesion. Preliminary cell culture results showed good cell adhesion and proliferation in the cross-linked random and aligned gelatin fiber mats.

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“…However, for some control wounds though the entire surface of the defect was covered with new epithelium, moderate number of inflammatory cells, predominantly lymphocytes and macrophages, were still present in the upper dermis. Though superficially neither control nor test wounds showed any reduction in defect area at 5th day, on measuring the wound re-epithelialisation it was found that both wounds have started healing (Balakrishnan et al, 2005). In a previous study has shown successful treatment with fucoidan-chitosan hydrogels which were tested in New Zealand rabbits with second degree burn (Sezer et al, 2008a).…”

Section: Wwwintechopencommentioning

confidence: 96%

“…Gelatine is commonly used in the treatment of wounds and burns, and acts as supportive tissue when used in the treatment of dermal burns with various biopolymers. Balakrishnan et al (2005) applied hydrogel formulations containing oxidised alginate and gelatine to the 1 cm 2 full-thickness skin wounds created in rat model and the results evaluated histologically. At 15th day, test wounds appeared reduced in size with new epithelium noted at both the edges of the defect with the proliferation of basal layer and formation of the rete pegs.…”

Section: Wwwintechopencommentioning

confidence: 99%

Biopolymers as Wound Healing Materials: Challenges and New Strategies

Sezer¹,

Cevher²

2011

Biomaterials Applications for Nanomedicine

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Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin

Cited by 855 publications

References 32 publications

Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl<SUB>2 </SUB>Hydrogel for Wound Dressing

Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl<SUB>2 </SUB>Hydrogel for Wound Dressing

Modifying Fish Gelatin Electrospun Membranes for Biomedical Applications: Cross-Linking and Swelling Behavior

Biopolymers as Wound Healing Materials: Challenges and New Strategies

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