Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl&lt;SUB&gt;2 &lt;/SUB&gt;Hydrogel for Wound Dressing

Dutta, Joydeep

doi:10.5923/j.chemistry.20120202.02

Cited by 43 publications

(17 citation statements)

References 21 publications

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“…Hydrogel dressings are designed to hold moisture on the surface of the wound, which prevents bacteria and oxygen from reaching the wound, thereby providing a barrier against infection [15]. This type of dressing also minimizes the loss of body fluids and accelerates the healing process [16].…”

Section: Introductionmentioning

confidence: 99%

Bromelain Loading and Release from a Hydrogel Formulated Using Alginate and Arabic Gum

et al. 2017

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An ideal wound dressing ensures a moist environment around the wound area and absorbs exudates from the wound surface. Topical application of bromelain to incised wounds has been shown to reprogram the wound microenvironment to promote effective tissue repair. Combining the characteristics of hydrogels and bromelain is therefore of great interest. Herein, we describe the development of a hydrogel, formulated using alginate and Arabic gum, for bromelain loading and release. The hydrogel formulation was evaluated using response surface methodology, considering the pH value and the concentration of alginate and Arabic gum. Bromelain loading and release were evaluated based on passive diffusion. Differential scanning calorimetry and Fourier transform infrared spectroscopy were performed to confirm bromelain immobilization in the hydrogel. The final hydrogel formulation had a swelling ratio of 227 % and incorporated 19 % of bromelain from a bromelain solution. Bromelain immobilization in the hydrogel was the result of hydrogen bond formation and was optimal at 4 °C after 4 h of contact. This evidence suggests that bromelain entrapment into a hydrogel is a promising strategy for the development of wound dressings that support the debridement of burns and wounds.

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Section: Introductionmentioning

confidence: 99%

Bromelain Loading and Release from a Hydrogel Formulated Using Alginate and Arabic Gum

et al. 2017

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“…It is probable that PEG plays the roles of low-molecular crosslinking sensitizer and polymer solution plasticizer following the mechanism discussed in work [15]. This scenario is implemented despite a reduction of the gel fraction, when PEG is added [16,17]. If the PEG concentration in the initial solution of the PVA -PEG system exceeds 5%, opaque clusters characterized by a high density are formed.…”

Section: Results and Their Discussionmentioning

confidence: 99%

Physical Properties of Radiation-Crosslinked Polyvinyl Alcohol-Polyethylene Glycol Hydrogels from the Viewpoint of Their Application as Medical Dressings

Neimash¹,

Kupianskyi²,

Olkhovyk³

et al. 2017

Ukr. J. Phys.

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The influence of component composition, as well as hydration and electron irradiation conditions, on mechanical, optical, diffusion, and hydrophilic properties of radiation-crosslinked hydrogels prepared on the basis of the polyvinyl alcohol-polyethylene glycol system has been investigated from the viewpoint of their application to the fabrication of medical dressings to treat burns and wounds. A significant impact of the electron irradiation intensity and the temperature of initial solutions on the processes of polymer radiation crosslinking is experimentally revealed and analyzed. The hydrophily of crosslinked hydrogels is demonstrated to depend more strongly on the exposure dose than on the gel composition. The optimal intervals of radiation doses and polymer concentrations, at which the radiation-crosslinked hydrogel satisfies requirements for medical dressing materials are determined. K e y w o r d s: radiation crosslinked hydrogels, polyvinyl alcohol-polyethylene glycol system, medical dressing materials.

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“…[23]. The thermogram was carried out by PerkinElmer Pyris 1 (PerkinElmer, Waltham, MA, USA) and was recorded from 30 to 500 °C under nitrogen flow at a rate of heating 10 °C/min.…”

Section: Methodsmentioning

confidence: 99%

A Photolithographic Approach to Polymeric Microneedles Array Fabrication

et al. 2015

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In this work, two procedures for fabrication of polymeric microneedles based on direct photolithography, without any etching or molding process, are reported. Polyethylene glycol (average molecular weight 250 Da), casted into a silicone vessel and exposed to ultraviolet light (365 nm) through a mask, cross-links when added by a commercial photocatalyzer. By changing the position of the microneedles support with respect to the vessel, different shapes and lengths can be achieved. Microneedles from a hundred microns up to two millimeters have been obtained just tuning the radiation dose, by changing the exposure time (5–15 s) and/or the power density (9–18 mW/cm2) during photolithography. Different microneedle shapes, such as cylindrical, conic or lancet-like, for specific applications such as micro-indentation or drug delivery, are demonstrated.

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Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl<SUB>2 </SUB>Hydrogel for Wound Dressing

Cited by 43 publications

References 21 publications

Bromelain Loading and Release from a Hydrogel Formulated Using Alginate and Arabic Gum

Bromelain Loading and Release from a Hydrogel Formulated Using Alginate and Arabic Gum

Physical Properties of Radiation-Crosslinked Polyvinyl Alcohol-Polyethylene Glycol Hydrogels from the Viewpoint of Their Application as Medical Dressings

A Photolithographic Approach to Polymeric Microneedles Array Fabrication

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