Evaluation of an integrated approach to the treatment of sleep disorders in patients with occupational occupational chronic mercury intoxication

Abstract

Introduction. The issues of studying the central nervous system (CNS) damage under the influence of mercury remain relevant at the present time.The aim of the study was to identify the relationship of dissomnic and psychological disorders in patients in the remote post-exposure period of chronic mercury intoxication (ChMI) and to substantiate the effectiveness of the proposed scheme of their therapy.Materials and methods. The study involved 30 patients in the long-term period with occupational chronic mercury intoxication (CHMI) and 30 patients in the control group (CG), with complaints of sleep disorders without chronic expressed diseases, not in contact with toxic production factors in professional activity, 84 men — residents of the Irkutsk region from the comparison group to assess the health-related quality of life comparable with patients in social and living conditions and not in contact with harmful production factors. A set of clinical, neurophysiological, psychological and statistical methods was used in study.Results. Based on the data of polysomnographic examination revealed differences in the nature and severity of insomnia in patients of these groups. Confirmed the mixed nature of insomniatic disorders in patients with chronic mercury intoxication. Patients CG revealed changes in the structure of night sleep has focused on intracomesa violations. It was found that patients with CHMI suffer from a more severe form of insomnia compared to patients with CG, which is confirmed by the data of medical and psychological testing. High rates of reactive and personal anxiety, moderate levels of depression and asthenic state, as well as low values of estimates on all scales of health-related quality of life (HRQL), including the total physical and mental components, were revealed in patients with CRMI. Research’s scales HRQL in patients CG with sleep disorders did not reveal any significant differences compared with those in the comparison group, indicating medium and high levels of overall quality of life.Conclusions. The adequacy of the use of a complex of therapeutic and preventive measures, including two main methods of treatment of insomnia disorders, is proved by improving the quality and quantity of sleep structure and emotional and personal sphere.