After the alert of the FDA in 1994, about induced skin injuries to patients during fluoroscopically guided procedures, several national and international organizations addressed the topic to improve the safety in interventional radiology. The number and complexity of interventional procedures are increasing during the past years, but the number and rate of skin injuries is not known because no comprehensive monitoring or reporting mechanism exists. In interventional procedures, patient dosimetry is difficult, as X-ray entrance skin areas and different beam projections, field sizes, electronic magnification, radiation qualities, etc., are unpredictable. In addition, service engineers can modify parameters affecting dose and image quality tailoring the systems to the particular requirements of the users. This article reviews the reported skin injuries in the scientific literature. Misuse, X-ray system faults or non-optimized operational protocol gives rise sometimes to the injuries. The available procedures to evaluate patient doses and practical advice to minimize risks are also discussed.