Evaluation of analgesic and anti-inflammatory activities of Rubia cordifolia L. by spectrum-effect relationships

Shen, Caihong; Liu, Cui-Ting; Song, Xijie; Zeng, Wei-Ya; Lü, Xiaoying; Zheng, Zhenxiao; Jie-Pan,; Zhan, Renya; Ping-Yan,

doi:10.1016/j.jchromb.2018.05.021

Cited by 49 publications

(31 citation statements)

References 27 publications

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“…Gray correlation analysis (GCA) was applied to evaluate the α‐glucosidase and PTP1B inhibitory activities according to the relative peak areas of major constituents in the samples from five localities. The GCA calculation process referred to the following literatures (Li et al, ; Shen et al, ; Zhu et al, ). In general, the higher the value of GCA, the better the inhibitory activities of compounds.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical identification of Lithocarpus polystachyus extracts by ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight–MS and their protein tyrosine phosphatase 1B and α‐glucosidase activities

Meng

Ding

Wang

et al. 2019

Biomedical Chromatography

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Lithocarpus polystachyus leaves exhibit antidiabetic activity and is consumed as a herbal tea in China. In this study, phytochemical profiles of L. polystachyus leaves were identified and characterized by ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight–MS in both positive and negative ion modes. A total of 17 compounds were tentatively characterized and identified by accurate mass and characteristic fragment ions. The total phenolic contents in the leaf extracts ranged from 9.0 to 13.4 g gallic acid equivalents/100 g of dry weight (DW). In addition, the effect of these extracts on inhibiting the activities of α‐glucosidase and protein tyrosine phosphatase 1B (PTP1B) were evaluated. L. polystachyus extracts demonstrated significant inhibition of α‐glucosidase (more than 88.1% at a concentration of 1.25 mg/mL) and acarbose (93.6% at a concentration of 5 mg/mL) while the PTP1B inhibition rate was over 84.3%. The antioxidant capacities of the leaf extracts were determined using 2,2‐diphenyl‐1‐picrylhydrazyl, ABTS, and ferric reducing ability of plasma methods and ranged from 50.5 to 72.5 g trolox, from 43.2 to 77.7 g trolox, and from 5.0 to 10.6 g butylated hydroxytoluene (BHT; equaling trolox or BHT per 100 g of DW), respectively. Based on these results, L. polystachyus can be considered as a functional food owing to its antidiabetic and antioxidative activities, which are attributed to its rich phenolic and dihydrochalcone contents.

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Section: Resultsmentioning

confidence: 99%

Phytochemical identification of Lithocarpus polystachyus extracts by ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight–MS and their protein tyrosine phosphatase 1B and α‐glucosidase activities

Meng

Ding

Wang

et al. 2019

Biomedical Chromatography

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“…Purpurin is the major active component of Rubia tinctorum L., [ 73 ] a common madder plant, and exhibits various pharmacological activities such as immunomodulatory, antioxidant, antidepressant and neuroprotection activities. [ 74,75 ] In vitro assays suggested that purpurin has inhibitory effect on the aggregation of the Tau‐derived VQIVYK (PHF6) peptide. In vivo experiments demonstrated that purpurin significantly ameliorated the AD‐like neurodegenerative symptoms and rescued neurotoxicity of Tau‐engendered phenotypes by inhibiting Tau accumulation and reducing Tau phosphorylation.…”

Section: Quinones and Its Role In Admentioning

confidence: 99%

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

Chen

Gao

Peng

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Alzheimer's disease (AD) is a hidden neurological degenerative disease, which main clinical manifestations are cognitive dysfunction, memory impairment and mental disorders. Neuroinflammation is considered as a basic response of the central nervous system. NLRP3 (Nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3) inflammasome is closely related to the occurrence of neuroinflammation. Activation of the NLRP3 inflammasome results in the release of cytokines, pore formation and ultimately pyroptosis, which has demonstrated one of the critical roles in AD pathogenesis. Inhibition of the activity of NLRP3 is one of the focuses of the research. Therefore, NLRP3 represents an attractive pharmacological target, and discovery compounds with good NLRP3 inhibitory activity are particularly important. Key findings Quinones have good neuroprotective effects and prevent AD, which may be related to their regulation of inflammatory response. The molecular docking was used to explore 12 quinones with AD prevention and treatment and NLRP3. Docking results showed that the combination of anthraquinones and NLRP3 were the best, and the top two chemical compounds were Purpurin and Rhein, which are the most promising NLRP3 inhibitors. Summary These quinones may provide the theoretical basis for finding lead compounds for novel neuroprotective agents. Quinones as NLRP3 inflammasomes inhibitors Da-bao Chen et al.

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“…On the other hand, raspberry ketone (RK) from Rheum officinalis inhibited melanogenesis by regulation of the posttranscriptional of tyrosinase gene expression [ 35 ]. In addition, Rheum officinalis contained tannins and gallic acid which act as antioxidant phenolic components [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Identification of Novel Bioactive Compound Derived from Rheum officinalis against Campylobacter jejuni NCTC11168

Yosri

Amin

Abed

et al. 2020

The Scientific World Journal

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Gastric diseases are increasing with the infection of Campylobacter jejuni. Late stages of infection lead to peptic ulcer and gastric carcinoma. C. jejuni infects people within different stages of their life, especially childhood, causing severe diarrhea; it infects around two-thirds of the world population. Due to bacterial resistance against standard antibiotic, a new strategy is needed to impede Campylobacter infections. Plants provide highly varied structures with antimicrobial use which are unlikely to be synthesized in laboratories. A special feature of higher plants is their ability to produce a great number of organic chemicals of high structural diversity, the so-called secondary metabolites. Twenty plants were screened to detect their antibacterial activities. Screening results showed that Rheum officinalis was the most efficient against C. jejuni. Fractionation pattern was obtained by column chromatography, while the purity test was done by thin-layer chromatography (TLC). The chemical composition of bioactive compound was characterized using GC-MS, nuclear magnetic resonance, and infrared analysis. Minimal inhibitory concentration (MIC) of the purified compound was 31.25 µg/ml. Cytotoxicity assay on Vero cells was evaluated to be 497 µg/ml. Furthermore, the purified bioactive compound activated human lymphocytes in vitro. The data presented here show that Rheum officinalis could potentially be used in modern applications aimed at the treatment or prevention of foodborne diseases.

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Evaluation of analgesic and anti-inflammatory activities of Rubia cordifolia L. by spectrum-effect relationships

Cited by 49 publications

References 27 publications

Phytochemical identification of Lithocarpus polystachyus extracts by ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight–MS and their protein tyrosine phosphatase 1B and α‐glucosidase activities

Phytochemical identification of Lithocarpus polystachyus extracts by ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight–MS and their protein tyrosine phosphatase 1B and α‐glucosidase activities

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

Identification of Novel Bioactive Compound Derived from Rheum officinalis against Campylobacter jejuni NCTC11168

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