2019
DOI: 10.2478/afpuc-2019-0018
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Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.

Abstract: Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats. The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract (100, 200 and 4… Show more

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Cited by 4 publications
(3 citation statements)
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“…Filtration was used to separate the plant material. A vacuum evaporator was used to concentrate the 70% ethanol extracts at lower pressure (12). The yield of the ethanol extract was 23.34 % w/w.…”
Section: Preparation Of Ethanol Extractmentioning
confidence: 99%
“…Filtration was used to separate the plant material. A vacuum evaporator was used to concentrate the 70% ethanol extracts at lower pressure (12). The yield of the ethanol extract was 23.34 % w/w.…”
Section: Preparation Of Ethanol Extractmentioning
confidence: 99%
“…2 C. sebestena has pharmacological activity, such as hepatoprotective, 3 hypoglycaemic, hypolipidemic, antioxidant, 4 antidiabetic, antibacterial, 2 anti-inflammatory, and analgesic. 5,6 The antioxidant is a molecule that significantly inhibits the oxidation of the other substance, although it presents in low concentration. Antioxidants are responsible for defence mechanisms to protect the body from damage to oxidation reactions.…”
Section: Introductionmentioning
confidence: 99%
“…2 Daun Cordia juga mengandung senyawa volatil sebesar 0,05%. 3 Daun cordia memiliki beragam aktivitas farmakologi, antara lain antibakteri, 4 analgetik, antiinflamasi, 5 antioksidan, 6 dan lain sebagainya. Studi mengenai toksisitas subakut dari ekstrak etil asetat daun Cordia menunjukan bahwa ekstrak tersebut tidak toksik terhadap hati.…”
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