Evaluation of analgesic, antipyretic and anti-inflammatory effects of methanol extract of traditional herbal medicine using rodents

Gupta, Mradu; Banerjee, Dalia; Mukherjee, Arup

doi:10.5897/jpp2013.0268

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…The HPLC-UV was used under conditions described by Mradu et al 17 Briefly, 15% acetonitrile and 85% of 0.1% phosphoric acid were held for 10 minutes and detected using a UV wavelength of 280 nm. A Grace Vydac 5 μm C18 300 (250 × 4.6 mm) column was used with a flow rate of 1.0 mL min .…”

Section: Analytical Methods For Quantification Of Trace Compoundsmentioning

confidence: 99%

Metaldehyde removal from drinking water by adsorption onto filtration media: mechanisms and optimisation

Rolph

Jefferson

Hassard

et al. 2018

Environ. Sci.: Water Res. Technol.

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a Trace micropollutants should be removed during drinking water production without increasing the disinfection-by-product formation potential or energy demand of the treatment process. We demonstrate the efficacy of different filtration media to remove metaldehyde through controlled batch experiments on water augmented with metaldehyde. Equilibrium concentrations of metaldehyde and surrogate organics were successfully described by the Freundlich isotherm. Metaldehyde can be attenuated to varying degrees with activated carbon and sand with an active and inactive biofilm with k f values ranging from 0.006-0.3. The presence of the active biofilm improved metaldehyde adsorption by sand media, due to additional biosorption mechanisms, a greater surface area or biodegradation. Baseline levels of competing natural organic matter surrogates (NOM) reduced overall adsorption efficacy but increasing concentrations of NOM did not impact metaldehyde removal efficacy in a significant way. Biological activated carbon was identified as the most suitable adsorbent of metaldehyde (94% removal) but sand with an acclimated biofilm was capable of acting as a bio-adsorbent of metaldehyde even under environmentally relevant concentrations (41% adsorption from 0.002.5 mg L −1). Moreover, we observed that thermal hydrolysis of metaldehyde occurred at 60°C, suggesting that thermal regeneration of GAC for this pesticide was possible at relatively low temperatures. Biological adsorption and thermal hydrolysis approaches presented herein offered a way forward to increase efficiency and cost effectiveness of existing treatments for metaldehyde. IntroductionIn Europe, water treatment works (WTW) are required to meet the European Union drinking water standard of 0.1 μg L −1 for individual pesticides. This includes the molluscicide, metaldehyde, which is an uncharged, low M w , highly soluble compound. Such characteristics make it difficult to remove in traditional drinking water treatment processes as evidenced by the fact that it is responsible for most pesticide related drinking water failures in the UK. Water impactOur study is topical, as it provides insights into adsorption of metaldehyde onto different sorbents. Bio-active carbon had the greatest metaldehyde removal through biosorption to biofilms which along with thermal hydrolysis represent strategies for improving the performance and resilience of filtration media to polar pesticides. overall metaldehyde adsorption capacity. 7,8 The impact of background interferences, on the metaldehyde adsorption, remains poorly quantified, in particular, the role of organic and inorganic compounds which are typically present in source waters. This is important as these compounds compete for adsorption sites in adsorptive media. Slow sand filters (SSFs) could provide an effective treatment for metaldehyde by promoting coupled adsorption and biosorption. 8 The adsorption efficiency of SSFs or microbial

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Section: Analytical Methods For Quantification Of Trace Compoundsmentioning

confidence: 99%

Metaldehyde removal from drinking water by adsorption onto filtration media: mechanisms and optimisation

Rolph

Jefferson

Hassard

et al. 2018

Environ. Sci.: Water Res. Technol.

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“…Seledri mengandung senyawa kimia diantaranya flavonoid yang salah satu bioaktivitasnya ialah menurunkan panas demam [5] . Sebagai antipiretik, flavonoid sering dikaitkan dengan potensinya sebagai inhibitor cyclooxygenase (COX), suatu enzim yang berperan penting dalam pembentukan mediator kimia yang terlibat dalam pembentukan radang yakni prostaglandin [6] .…”

Section: Pendahuluanunclassified

Ekstrak Herba Seledri (Apium Graveolens L.) (Microwave-Assisted Extraction) Sebagai Antipiretik Pada Mencit Jantan Yang Diinduksi Demam Dengan Vaksin Dpt-Hb-Hib

Rahminiwati,

Indriani,

Hidayanti

2024

J. Vet. Biomed.

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Seledri (Apium graveolens L) mengandung flavonoid, suatu senyawa yang dilaporkan mempunyai efek antiinflamasi melalui mekanisme inhibisi terhadap cyclo oxidase yakni suatu enzim yang berperan penting dalam proses demam terkait peradangan. Flavonoid mempunyai kelarutan yang baik dalam pelarut polar seperti alkohol. Dengan mempertimbangkan Microwave-Assisted Extraction merupakan salah satu cara penarikan flavonoid yang lebih baik dibandingkan dengan maserasi konvensional, penelitian ini dilakukan untuk menetapkan efektivitas ekstrak etanol 70% herba seledri hasil dari MAE sebagai antipiretik pada mencit yang diinduksi vaksin DPT-HB-HIB. Penelitian dilakukan pada 25 ekor mencit yang dibagi menjadi lima kelompok perlakuan yakni kelompok yang diberi CMC Na 0,5 % sebagai kontrol negatif, paracetamol 1,82 mg/20 g BB sebagai kontrol positif dan ekstrak herba seledri dosis 2, 4, dan 6 mg/20 g BB sebagai kelompok perlakuan. Sediaan diberikan peroral pada mencit yang mengalami demam setelah divaksin dengan DPT. Pengukuran suhu tubuh dilakukan sebelum dan sesudah di vaksin DPT dan setiap 15 menit sekali selama perlakuan. Hasil penelitian menunjukan bahwa ekstrak herba seledri dapat menurunkan suhu tubuh mencit. Efek terbaik terjadi pada dosis 6 mg/20 g BB dan efeknya setara dengan kontrol positif. Sedangkan onset paling cepat terjadi pada menit ke-30 pada dosis 4 mg/20 gBB. Dengan demikian ekstrak herba seledri hasil MAE potensial sebagai antipiretik.

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“…Fig.2shows different pharmacological effects amla fruit including antidiabetic,83,84 anti-inammatory,85,86 cardioprotective,87,88 immunomodulator, 89 memory enhancer,90 wound healer, 91 neuroprotector,92,93 free radical scavenger,94,95 eye protector,96 antithyroidism,97 antimicrobial,98 and most important anticancer 99,100. Amla can also be helpful in treating a plethora of diseases and disorders including hyperacidity, constipation, colitis, haemorrhoids, dyspepsia, gastritis, ophthalmic issues, anaemia, cough, asthma, osteoporosis, premature greying of hair, weakness and fatigue, nerve debility and liver complaints 101.…”

mentioning

confidence: 99%

Thermal and nonthermal processing of an underutilized fruit Emblica officinalis (Amla): a sustainable approach

Tewari

Kumar

Sharma

2023

Sustainable Food Technol.

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Evaluation of analgesic, antipyretic and anti-inflammatory effects of methanol extract of traditional herbal medicine using rodents

Cited by 6 publications

References 12 publications

Metaldehyde removal from drinking water by adsorption onto filtration media: mechanisms and optimisation

Metaldehyde removal from drinking water by adsorption onto filtration media: mechanisms and optimisation

Ekstrak Herba Seledri (Apium Graveolens L.) (Microwave-Assisted Extraction) Sebagai Antipiretik Pada Mencit Jantan Yang Diinduksi Demam Dengan Vaksin Dpt-Hb-Hib

Thermal and nonthermal processing of an underutilized fruit Emblica officinalis (Amla): a sustainable approach

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