Evaluation of analgesic, antipyretic and anti-inflammatory activity on Cordia dichotoma G. Forst. Leaf

Gupta, Rajesh Kumar; Kaur, Jagjit

doi:10.4103/0974-8490.147227

Cited by 18 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Paw edema induced by carrageenan is an acute model of inflammation widely used to evaluated anti-inflammatory effect of natural products. [ 31 32 33 ] After injection, carrageenan immediately produces edema, hyperalgesia, and erythema, resulting from the action of proinflammatory agents such as bradykinin, histamine, tachykinins, and complement. [ 34 ] Our results showed that all extracts present anti-inflammatory effects, being GOJI extract more effective in reducing paw edema than BLUE and CRAN extracts.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory activity of berry fruits in mice model of inflammation is based on oxidative stress modulation

et al. 2016

View full text Add to dashboard Cite

Background:Many fruits have been used as nutraceuticals because the presence of bioactive molecules that play biological activities.Objective:The present study was designed to compare the anti-inflammatory and antioxidant effects of methanolic extracts of Lycium barbarum (GOJI), Vaccinium macrocarpon (CRAN) and Vaccinium myrtillus (BLUE).Materials and Methods:Mices were treated with extracts (50 and 200 mg/kg, p.o.), twice a day through 10 days. Phytochemical analysis was performed by high-performance liquid chromatography. Antioxidant activity was determine by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, reducing power, lipid peroxidation thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and catalase (CAT) activity. Anti-inflammatory activity was evaluated by paw edema followed by determination of myeloperoxidase (MPO) and TBARS.Results:High amount of phenolic compounds, including rutin, were identified in all berries extracts. However, quercetin was observed only in BLUE and CRAN. GOJI presents higher scavenging activity of DPPH radical and reducing power than BLUE and CRAN. The extracts improved antioxidant status in liver; BLUE showed the largest reduction (75.3%) in TBARS when compared to CRAN (70.7%) and GOJI (65.3%). Nonetheless, CAT activity was lower in BLUE group. However, hepatic concentrations of GSH were higher in animals treated with GOJI rather than CRAN and BLUE. Despite all fruits caused a remarkable reduction in paw edema and TBARS, only BLUE and CRAN were able to reduce MPO.Conclusion:These results suggest that quercetin, rutin, or other phenolic compound found in these berry fruits extracts could produce an anti-inflammatory response based on modulation of oxidative stress in paw edema model.SUMMARY Within fruits broadly consumed because of its nutraceuticals properties include, Lycium barbarum (Goji berry), Vaccinium myrtillus (Blueberry or Bilberry) and Vaccinium macrocarpon (Cranberry)The objectives of this study were the investigation and comparison of chemical composition, antioxidant activity “in vitro” and “in vivo” and anti inflammatory property of berry fruits bought dry form.In summary, two main findings can be addressed with this study: (1) Berry fruits presented antioxidant and anti inflammatory activities “in vitro” and “in vivo”; (2) the extracts of GOJI, CRAN, and BLUE modulate the inflammatory process by different mechanisms.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory activity of berry fruits in mice model of inflammation is based on oxidative stress modulation

et al. 2016

View full text Add to dashboard Cite

show abstract

“…dichotoma G. Forst. methanolic leaf extracts are analgesic, antipyretic and anti-inflammatory (Gupta and Kuar, 2015). Ferreira Matias et al (2015) reported the presence of luteolin (3′,4′,5,7-tetrahydroxyflavone), apigenin and lupeol in C. dichotoma G. Forst.…”

Section: Medicinal Propertiesmentioning

confidence: 99%

A Review of Cordia Species Found in the Caribbean: Cordia Obliqua Willd., Cordia Dichotoma G. Forst. And Cordia Collococca L

Aimey

Goldson-Barnaby

Bailey

2020

International Journal of Fruit Science

View full text Add to dashboard Cite

Members of the Cordia genus possess medicinal properties. There is however limited scientific literature on species within the genus that exists in the Caribbean, namely Cordia obliqua Willd., Cordia dichotoma G. Forst. and Cordia collococca L. This paper provides an overview of these plant species based on their morphology, growth conditions, fruiting season, nutritional and medicinal properties, current processing methods as well as their potential applications in the food and pharmaceutical industries.

show abstract

“…Methanol extract high dose (400 mg/kg) was found to be highly significant as compared to standard drug 36 . Therefore, results from various published work confirm and supports the traditional use of C. dichotoma for management of pyrexia, inflammation and painful conditions.…”

Section: Analgesic Anti-inflammatory and Antipyretic Activitymentioning

confidence: 99%

Exploring Phytochemicals and Pharmacological Uses of Cordia Dichotoma (Indian Cherry): A Review

Prajapati

Kar

Maurya

et al. 2017

J. Drug Delivery Ther.

View full text Add to dashboard Cite

The use of phytoconstituents single or combined with standard medicines has been utilized in cure of different diseases. Many plants of genus Cordia comprise of trees and shrubs are widely distributed in warmer regions and have been utilized in management of various diseases. Various phytoconstituents like flavonoids, alkaloids, terpenes, tannins, and glyceridess having different activities were screened and isolated from different parts of C. dichotoma. Various important Pharmacological properties including Antiulcer, Contraceptives, anti-inflammatory, anthelmintic, analgesic, anticancer, Antioxidant, antimicrobial, hepatoprotective, antidiabetic and others have been well documented for this plant. Therefore, we have briefly reviewed the various bioactivities of C. dichotoma to improve our knowledge on plant phytochemicals as therapeutic entities. The present review describes the various phytoconstituents and therapeutic potential of C. dichotoma that can be followed for future research on this plant for human health benefits.

show abstract

Evaluation of analgesic, antipyretic and anti-inflammatory activity on Cordia dichotoma G. Forst. Leaf

Cited by 18 publications

References 8 publications

Anti-inflammatory activity of berry fruits in mice model of inflammation is based on oxidative stress modulation

Anti-inflammatory activity of berry fruits in mice model of inflammation is based on oxidative stress modulation

A Review of Cordia Species Found in the Caribbean: Cordia Obliqua Willd., Cordia Dichotoma G. Forst. And Cordia Collococca L

Exploring Phytochemicals and Pharmacological Uses of Cordia Dichotoma (Indian Cherry): A Review

Contact Info

Product

Resources

About