Evaluation of anti depressant activity of petroleum ether extract of <i>Rosa centifolia</i> in swiss albino mice

Jeyamani, S. Vedha Pal; Sheeba, D. A. Helen; Rajan, Asha K; Bhavya, E.; Magesh, M.

doi:10.5958/0974-360x.2018.00371.2

Rese. Jour. of Pharm. and Technol.

2018

DOI: 10.5958/0974-360x.2018.00371.2

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Evaluation of anti depressant activity of petroleum ether extract of Rosa centifolia in swiss albino mice

S. Vedha Pal Jeyamani¹,

D. A. Helen Sheeba²,

Asha K Rajan³

et al.

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Synthesis and Assessment of Sub-acute Toxicity of Novel Rosin Esters of Polyethylene Glycol 200 in Swiss Albino Mice

Burakale¹,

Bhise²,

Sakarkar³

et al. 2021

RJPT

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The objective of present investigation was to synthesize and assess sub-acute toxicity of novel rosin esters using Swiss Albino mice. Assessment of the safety and toxicity of rosin esters is very important step before its use in pharmaceuticals. The solutions of rosin esters were prepared in corn oil to perform acute (28d) oral toxicity study in Swiss Albino mice as animal model of both sexes. The oral administration of rosin esters at the dose of 25 mg/kg of body weight and constant volume was administered to the mice. One group of mice was kept as a control group. Toxicity of the rosin esters was assessed by using various tests like behavioral changes, clinical signs, mortality and morbidity, biochemical tests, haematological tests, relative organ weights and histopathology tests. The body weights and food-water consumption by mice were recorded on weekly basis. The study results revealed that, there were no signs and incidences of toxicity or mortality in mice during the study period. No significant difference between treated (rosin ester administered) and control group of mice were recorded in the observations of different tests, body weights and food-water consumption. The histopathological examination of organs from the mice treated with rosin esters for 28d does not show any signs of toxic effects when compared with the control group. Therefore, the present investigation confirmed the non-toxic nature of novel rosin ester at 25mg/kg daily dose of body weight after oral administration in both the sexes.

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Synthesis and Assessment of Sub-acute Toxicity of Novel Rosin Esters of Polyethylene Glycol 200 in Swiss Albino Mice

Burakale¹,

Bhise²,

Sakarkar³

et al. 2021

RJPT

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Evaluation of Antidepressant activity of Tricholepis glaberrima DC using various Paradigms

Jodh¹,

Tawar²,

Kachewar³

2022

RJPT

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In the present experiment, Tricholepis glaberrima DC has been taken to study its antidepressant activity. The study was carried out in two different doses of the test drug. The animals were divided into 4 groups of 5 animals each, respectively. Mice in Group I (control) and II (standard) were administered distilled water, per oral and Imipramine 10mg/kg, per oral once respectively. Group III and IV were treated with the test drug METG in the dose of 100mg/kg and 300mg/kg, respectively. Findings of the test groups were compared with that of standard as well as plain control groups. In despair swim test and Tail suspension method, METG (100mg/kg and 300mg/kg per oral) depicted significant (*p<0.05 and p<0.01) results, in a dose dependent manner, when compared to vehicle treated group, indicating significant antidepressant activity. The results obtained in the present study for antioxidant activity indicate that the plants of Tricholepis glaberrima DC are a significant source of natural antioxidants. This test reveals the antidepressant activity of Tricholepis glaberrima DC Via serotonergic, adrenergic mechanism in a dose dependent pattern.

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A Critical Analysis of Medicinal plants for Anti-Depressant action with their Phyto-Constituent and Mechanism of Action

Bhushan Mishra,

Mishra

2024

AJPS

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Depression or stress refers to a state of sad feelings and loss of interest in pleasurable activities characterized by retardation of thoughts and actions, appetite and weight changes, restlessness as well as in sleep disturbance. All the current evidences implicate alteration in the firing pattern of a subset of biogenic amines in the central nervous system. There are adequate number of synthetic drugs used to treat depression as standard treatment for clinically depressed patient, however only 30% of patients respond satisfactorily to the existing medicines and the remaining do not attain full recovery. Many scientists are investigating on herbal drugs for mitigating this disorder that shown antidepressant properties by virtue of synergistic effect of their phyto constituents. In this review article we emphasize to give an outline of certain medicinal plants with their constituents and mechanism of action which have been explored for their antidepressant action.

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Evaluation of anti depressant activity of petroleum ether extract of Rosa centifolia in swiss albino mice

Cited by 3 publications

References 0 publications

Synthesis and Assessment of Sub-acute Toxicity of Novel Rosin Esters of Polyethylene Glycol 200 in Swiss Albino Mice

Synthesis and Assessment of Sub-acute Toxicity of Novel Rosin Esters of Polyethylene Glycol 200 in Swiss Albino Mice

Evaluation of Antidepressant activity of Tricholepis glaberrima DC using various Paradigms

A Critical Analysis of Medicinal plants for Anti-Depressant action with their Phyto-Constituent and Mechanism of Action

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