Evaluation of Anti-hyperglycemic Effect of Sub-fractions Derived from Ethanol-aqueous Fraction of Balanites aegyptiaca Leaves in Streptozotocin-induced Diabetic Rats

Mhya, Daniel Hassan; Anigo, Kola Matthew; Umar, I.A.; Alegbejo, JO

doi:10.3923/ajbs.2019.164.172

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…These are the Type 1 and 2 diabetes mellitus which are the most common. The breakdown of insulin producing cells by auto immune response is the leading cause of Type 1 diabetes mellitus while Type 2 diabetes mellitus are caused by insulin resistance and a progressive insulin secretory defect due to the failure of β-cells (Mhya et al, 2019). Alloxan is a compound experimentally used to induce Type 1 diabetes and in so doing, selectively destroys the pancreatic insulin producing β-cells (Ankur and Ali, 2012).…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats

Adefolalu¹,

Salawa²,

Gara³

et al. 2020

Nig J Bas App Sci

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This study investigated the hypoglycemic and hypolipidemic effect of the oral administration of methanol extract of Hibiscus sabdariffa seed in alloxan induced diabetic albino rats. Two different doses (200 and 400 mg/kg) of the methanol extract of Hibiscus sabdariffa seed were administered daily to two groups of diabetic rats for a period of two weeks. Metformin (250 mg/kg) was given as the reference standard drug. Phytochemical, acute toxicity, fasting blood glucose, body weight, cholesterol, triglycerides and lipoproteins levels were determined using standard methods. Acute toxicity of methanol extract of Hibiscus sabdariffa seed was estimated to be greater than 5000 mg/kg body weight. There was an initial decrease in the body weight of the experimental animals after induction of diabetes which increased significantly (p<0.05) by the second week of treatment. The fasting blood glucose levels of the treated diabetic rats were significantly decreased at the second week of treatment with the group that received 400 mg/kg of extract recording the lowest fasting blood glucose level. The cholesterol, triglycerides and low density lipoproteins levels of the diabetic treated rats were significantly reduced while the high density lipoproteins level significantly increased. It can therefore be concluded that Hibiscus sabdariffa seed has the ability to lower blood sugar and maintain a stable lipid level. Keywords: Hypoglycemic, hypolipidemic, Alloxan, Phytochemical, Hibiscus sabdariffa

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Section: Introductionmentioning

confidence: 99%

Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats

Adefolalu¹,

Salawa²,

Gara³

et al. 2020

Nig J Bas App Sci

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“…Therefore, there are indications of beta-cell damage resulting from hypoinsulinemia, hyperglycemia, and followed by excessive breakdown of muscle protein and fat to meet the energy requirements that are lacking due to the inadequacy of carbohydrates as an energy supplier. There was also a decrease in the rest of the extract treated groups with a value below the range of Group I [15], [24], [25], [26].…”

Section: Discussionmentioning

confidence: 85%

The Effect of Ethanol and Ethyl Acetate Fraction of Chayote fruit (Sechium edule Jacq. Swartz) on the Oxidative Stress and Insulin Resistance of Male White Rat Model Type 2 Diabetes Mellitus

Siahaan

Illyas

Lindarto

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Oxidative stress in type 2 diabetes mellitus (T2D) causes insulin resistance and disordered insulin secretion. Pathomechanisms of T2D consist of dysfunctional pancreatic β-cell and insulin resistance caused by free radical (reactive oxygen species and reactive nitrogen species) that produced from the glucose metabolism pathway. Insulin resistance can be measured using the homeostatic model assessment of insulin resistance (HOMA-IR). Oxidative stress can measure through the activities of malondialdehyde (MDA) and superoxide dismutase (SOD). AIM: This research aims to study the potential of chayote (Sechium edule Jacq. Swartz) to be used as antihyperglycemic in T2D. MATERIALS AND METHODS: This research was conducted with a post-test randomized controlled group design. Eleven groups with four male rats each were used. Normal untreated rats were treated under ad libitum feeding and drinking condition. Meanwhile, the rat models were induced with the combination of 45 mg/kg b.w. streptozotocin, 110 mg/kg b.w. nicotinamide, 40.5 mg/kg b.w. metformin, high-fat diet, and/or chayote extract. The chayote extract was orally administered to the rat in the form of ethanol extract and/or ethyl acetate fraction, with three dosages of 45 mg/kg b.w., 100 mg/kg b.w., and 150 mg/kg b.w. for each extract type. The body weight, glucose level, insulin level, MDA, and SOD activities were measured. The HOMA-IR was used. RESULTS: The lowest body weight of the rat model in week 0 was 145 ± 25.31, founded in Group H that was treated with ethyl acetate fraction of chayote extract (45 mg/kg b.w.). The lowest blood sugar level in the group with 2 h glucose load was 112.5 ± 27.00 on average, found in Group G that was treated with chayote ethanolic extract (150 mg/kg b.w.). The highest SOD in the group treated with chayote extract was 1.27 ± 0.20, founded in Group H treated with ethyl acetate 45 mg/kg b.w. The lowest level of MDA was 0.86 ± 0.70 in Group H treated with ethyl acetate 45 mg/kg b.w. The lowest fasting blood sugar spectrophotometer level was 150.54 ± 17.24 mg/dl in Group K with metformin treatment, followed by 155.16 ± 31.92 mg/dl in Group K treated 45 mg/kg b.w. ethanol treatment. The highest insulin level was 6.14 ± 0.71, founded in Group F that was treated with chayote ethanolic extract 100 mg/kg b.w. The lowest measurement of HOMA-IR was 0.16 ± 0.80 in Group E treated with ethanol extract of chayote 45 mg/kg b.w. CONCLUSION: Ethanol extract and fractionation of chayote work as an antioxidant and anti-insulin resistance.

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Development of Vegetative Propagation Strategies for Balanites aegyptiaca in the Sahel, Niger

Massaoudou

Rabiou²,

Félix

et al. 2022

International Journal of Forestry Research

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Forests have always been a source of wood, food, and medicine for the rural populations of the Sahel. Anthropogenic and animal pressures often lead to low tree recruitment rates and seedling survival. Under certain conditions, multipurpose species such as Balanites aegyptiaca have shown dramatic decreases in population numbers. The objective of the present study is to determine the natural colonisation behaviour of B. aegyptiaca and to develop vegetative propagation strategies. Surveys were carried out in the agroforest parklands of the Regional Centre for Agricultural Research of Maradi Research Station. An inventory was carried out in 1,500 m2 plots to determine the species’ regeneration methods. We then tested seed germination success, and suckering induction, air-layering, and stem cuttings were carried out to determine the techniques best suited for the propagation of B. aegyptiaca. It emerged from this study that in nature, B. aegyptiaca is propagated naturally by dispersion of seeds (81.2%), as well as by rejection of the strain (13.5%) and by suckering (5.2%). The germination test showed that heavy seeds (38.4%) germinated best because they have a higher nutrient reserve. With a success rate of 11.1%, distal suckers react better than proximal suckers (5.5%) because they quickly acquire relative independence from the mother plant. As for air-layering, stems with large diameters react better (53.3%) than those with small diameters (46.6%) because they have thicker bark and store a large amount of elaborate sap responsible for rhizogenesis. In the stem segment cutting test, cuttings of small diameter react better at 30.8% than those of large diameter (12.6%) because they have a higher number of meristematic tissues. The stem segment cuttings seem to be the best adaptable alternative to the natural propagation of B. aegyptiaca because it combines ease of use, low cost, and a significant success rate.

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Evaluation of Anti-hyperglycemic Effect of Sub-fractions Derived from Ethanol-aqueous Fraction of Balanites aegyptiaca Leaves in Streptozotocin-induced Diabetic Rats

Cited by 4 publications

References 18 publications

Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats

Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats

The Effect of Ethanol and Ethyl Acetate Fraction of Chayote fruit (Sechium edule Jacq. Swartz) on the Oxidative Stress and Insulin Resistance of Male White Rat Model Type 2 Diabetes Mellitus

Development of Vegetative Propagation Strategies for Balanites aegyptiaca in the Sahel, Niger

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