Evaluation of anti-inflammatory activity of latex of Calotropis procera in different models of inflammation

Sangraula, H; Dewan, Syed Masudur Rahman; Kumar, Vijay

doi:10.1163/156856001760209806

Cited by 37 publications

(20 citation statements)

References 20 publications

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“…Fasting blood glucose levels were measured on day 3 and rats with blood glucose level greater than 9.7 mmol/l (175 mg/dl) were included in the study (Yadav et al, 2002). The standard anti-diabetic drug and test drugs were administered at 10 a.m. to the diabetic rats once daily at doses that were considered safe based on previous work (Sangraula et al, 2002;Mahdi et al, 2003).…”

Section: Experimental Designmentioning

confidence: 99%

Antioxidant and protective effect of latex of Calotropis procera against alloxan-induced diabetes in rats

Roy

Sehgal

Padhy

et al. 2005

Journal of Ethnopharmacology

119

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Section: Experimental Designmentioning

confidence: 99%

Antioxidant and protective effect of latex of Calotropis procera against alloxan-induced diabetes in rats

Roy

Sehgal

Padhy

et al. 2005

Journal of Ethnopharmacology

119

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“…Both DL and MeDL significantly inhibited joint inflammation induced by FCA. The latex had been reported to exhibit potent antiinflammatory activity in various acute and chronic models of inflammation (Sangraula et al, 2002). It has been shown to inhibit oedema formation and cellular influx associated with inflammation induced by various mediators (Arya and Kumar, 2005).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of latex of Calotropis procera in Freund's Complete Adjuvant induced monoarthritis

Kumar

Roy

2008

Phytotherapy Research

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The protective effect of latex of Calotropis procera in Freund's Complete Adjuvant (FCA) induced monoarticular arthritis was evaluated in rats. Arthritis was induced by a single intra-articular injection of 0.1 mL of 0.1% FCA in the right ankle joint. The effect of dried latex (DL, 200 and 400 mg/ kg) and its methanol extract (MeDL, 50 and 500 mg/ kg) following oral administration was evaluated on joint inflammation, hyperalgesia, locomotor function and histology at the time of peak inflammation. The effects of DL and MeDL were compared with antiinflammatory drugs phenylbutazone (100 mg/ kg), prednisolone (20 mg/kg), rofecoxib (20 and 100 mg/ kg) and immuno-suppressant methotrexate (0.3 mg/ kg). Daily oral administration of DL and its methanol extract (MeDL) produced a significant reduction in joint inflammation (about 50% and 80% inhibition) and associated hyperalgesia. The antihyperalgesic effect of MeDL was comparable to that of rofecoxib. Both DL and MeDL produced a marked improvement in the motility and stair climbing ability of the rats. The histological analysis of the arthritic joint also revealed significant reduction in oedema and cellular infiltration by MeDL that was comparable to that of rofecoxib. Thus, our study suggests that the latex of C. procera has the potential to be used as an antiarthritic agent.

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“…78-84). Various extracts of the plant have been reported to have antiinflammatory, analgesic, and antipyretic activities [3][4][5][6][7]. Recently, antioxidant and antibacterial activities of the methanolic extract of the plant have also been published [8].…”

Section: Introductionmentioning

confidence: 99%

Exploring Applications of Procerain B, a Novel Protease from Calotropis procera, and Characterization by N-Terminal Sequencing as well as Peptide Mass Fingerprinting

Singh

Dubey

2011

Appl Biochem Biotechnol

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Procerain B is a novel cysteine protease isolated from Calotropis procera by our group and published recently. We have further characterized the enzyme by N-terminal sequencing and peptide mass fingerprinting. Procerain B showed maximum sequence similarity (80%) with Asclepain. Moreover, the characteristic VDWR motif of cysteine proteases is present in procerain B. The N-terminal and peptide mass fingerprinting analysis showed a distinct nature of the enzyme. Various applications of the enzyme were also evaluated. Procerain B is very effective in milk-clotting and may be a potential candidate for this process in the cheese industry. Additionally, the enzyme has potential application as dietary supplement to aid digestion. Effects of various metal ions on milk-clotting activity were also studied. The milk-clotting activity was increased in case of few metals while others have a negative effect. It is worth mentioning that the easy availability of plant material and simple purification method makes industrial production of the enzyme feasible. A protease with easy purification and suitable properties for application is always desired.

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Evaluation of anti-inflammatory activity of latex of Calotropis procera in different models of inflammation

Cited by 37 publications

References 20 publications

Antioxidant and protective effect of latex of Calotropis procera against alloxan-induced diabetes in rats

Antioxidant and protective effect of latex of Calotropis procera against alloxan-induced diabetes in rats

Protective effect of latex of Calotropis procera in Freund's Complete Adjuvant induced monoarthritis

Exploring Applications of Procerain B, a Novel Protease from Calotropis procera, and Characterization by N-Terminal Sequencing as well as Peptide Mass Fingerprinting

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