Evaluation of anti-inflammatory and analgesic activities of extracts from herb of Chelidonium majus L.

Mikołajczak, Przemysław Ł.; Kędzia, Bogdan; Ożarowski, Marcin; Kujawski, Radosław; Bogacz, Anna; Bartkowiak‐Wieczorek, Joanna; Białas, W.; Gryszczyńska, Agnieszka; Buchwald, Waldemar; Szulc, Michał; Wasiak, Natalia; Górska-Paukszta, Małgorzata; Baraniak, Justyna; Czerny, Bogusław; Seremak‐Mrozikiewicz, Agnieszka

doi:10.5114/ceji.2015.54607

Cited by 31 publications

(24 citation statements)

References 39 publications

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“…In the present study, we observed the expression ratios of IL-1β and IL-6 on LPS-stimulated group was 5,936 and 2,169, respectively. These results are in agreement with previous reports by Zhang et al (2015), Mikołajczak et al (2015), and Won et al (2006) where most studies reported that the expression levels of IL-1β to the LPS relatively higher than the other proinflammatory mediators (Won et al 2006, Mikołajczak et al 2015, Zhang et al 2015.…”

Section: A C Bsupporting

confidence: 94%

Ecklonia cava (Laminariales) and Sargassum horneri (Fucales) synergistically inhibit the lipopolysaccharide-induced inflammation via blocking NF-κB and MAPK pathways

Sanjeewa¹,

Fernando²,

Kim³

et al. 2019

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Ecklonia cava (EC) has been widely utilized as an ingredient in commercial products such as functional foods and cosmeceuticals. Recently it has been found that Sargassum horneri (SH) has been invading on Jeju Island coast area by its huge blooming. Moreover, both seaweeds are considering as important ingredients in traditional medicine specifically in East-Asian countries (China, Japan, and Korea). In the present study, we attempted to compare anti-inflammatory properties of 70% ethanolic extracts of EC (ECE), SH (SHE), and their different combinations on lipopolysaccharide (LPS)-activated RAW 264.7 cells. Results indicated that 8 : 2 combinations of ECE : SHE significantly inhibited LPS-activated inflammatory responses (cytokines, protein, and gene expression) in RAW 264.7 macrophage cells compared to the respective extracts and other combinations. The synergistic effect of ECE and SHE was found to be prominent than the effects of ECE or SHE alone. These observations provide useful information for the industrial formulation of functional materials (functional foods and cosmeceuticals) using these two particular seaweeds in Jeju Island of South Korea.

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Section: A C Bsupporting

confidence: 94%

Ecklonia cava (Laminariales) and Sargassum horneri (Fucales) synergistically inhibit the lipopolysaccharide-induced inflammation via blocking NF-κB and MAPK pathways

Sanjeewa¹,

Fernando²,

Kim³

et al. 2019

ALGAE

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“…Although sometimes a lack of correlation between the results at the formation of the protein and transcriptional occurs and reflects the complex interaction at the level of transcription and translation of particular substance of natural origin ( Ożarowski et al, 2013 , 2015 ; Mikołajczak et al, 2015 ), clearly establish the profile of anti-inflammatory OAO-ASA (8) and the mechanisms responsible for this is not possible on the basis of the obtained results.…”

Section: Discussionmentioning

confidence: 89%

Strong and Long-Lasting Antinociceptive and Anti-inflammatory Conjugate of Naturally Occurring Oleanolic Acid and Aspirin

et al. 2016

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The conjugate 8 was obtained as a result of condensation of 3-hydroxyiminooleanolic acid morfolide (7) and aspirin in dioxane. Analgesic effect of OAO-ASA (8) for the range of doses 0.3–300.0 mg/kg (p.o.) was performed in mice using a hot-plate test. Anti-inflammatory activity was assessed on carrageenan-induced paw edema in rats for the same range of doses. The conjugate OAO-ASA (8) did not significantly change locomotor activity of mice, therefore sedative properties of the compound should be excluded. The compound 8 proved a simple, proportional, dose-dependent analgesic action and expressed strong anti-inflammatory activity showing a reversed U-shaped, dose-dependent relation with its maximum at 30.0 mg/kg. After its combined administration with morphine (MF, 5.0 mg/kg, s.c.) the lowering of antinociceptive activity was found; however, the interaction with naloxone (NL, 3.0 mg/kg, s.c.) did not affect the antinociceptive effect of OAO-ASA (8), therefore its opioid mechanism of action should be rather excluded. After combined administration with acetylsalicylic acid (ASA, 300.0 mg/kg, p.o.) in hot-plate test, the examined compound 8 enhanced the antinociceptive activity in significant way. It also shows that rather the whole molecule is responsible for the antinociceptive and anti-inflammatory effect of the tested compound 8, however, it cannot be excluded that the summarizing effect is produced by ASA released from the compound 8 and the rest of triterpene derivative. The occurrence of tolerance for triterpenic derivative 8 was not observed, since the analgesic and anti-inflammatory effects after chronic administration of the conjugate OAO-ASA (8) was on the same level as after its single treatment. It seemed that the anti-inflammatory mechanism of action of OAO-ASA (8) is not simple, even its chronic administration lowered both blood concentration of IL-6 and mRNA IL-6 expression. However, the effects of the conjugate OAO-ASA (8) on TNF-α level and mRNA expression were opposite. Moreover, compound 8 did not change unequivocally mRNA TLR1, and TLR3 expression. Concluding, the obtained results regarding the antinociceptive and anti-inflammatory activity of new conjugate of oleanolic acid oxime and acetylsalicylic acid (OAO-ASA 8) are very interesting, but for explanation of its mechanism of action, more detailed studies are necessary.

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“…Quantitative determination for coptisine and chelidonine were performed at λ=240 nm, for sanguinarine and chelerythrine -λ=280 nm and for berberine -λ=345 nm by an external standard method. Standard solutions were prepared in methanol [5].…”

Section: Determination Of Alkaloids By Hplcmentioning

confidence: 99%

“…Chelidonium majus L. (CM, greater celandine) belongs to Papaveraceae and it is widespread throughout the world, including Europe, Asia, Northwest Africa and North America [1]. The aerial part of this plant contains isoquinoline alkaloids, such as chelidonine, chelerythrine, sanguinarine, berberine, coptisine, and stylopine (more than 30 alkaloids) [2][3][4][5]. Moreover, the presence of flavonoids, saponins, organic acids, vitamins, carotenoids, tyramine and several hydroxycinnamic acid derivatives including caffeoylmalic, chelidonic, malic and citric acids has been also reported [1].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of antioxidant activities of fractionated extracts from seedlings and herb ofChelidonium majusL. using DPPH, ABTS and FRAP methods

et al. 2016

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Summary Introduction: Our study is a part of a trend of studies on the antioxidative properties of Chelidonium majus extracts or their fractions suggesting that antioxidant activities may depend on total flavonoid and/or alkaloid contents. Objective: This study focused on the examination of antioxidative activities of full water extract, non-protein fraction and protein fraction of the extract from aerial parts of mature plants and young seedlings. Methods: Total flavonoid and alkaloid contents were evaluated by spectrometric methods. Quantitative determination of chelidonine, coptisine, sanquinarine, berberine was made by HPLC-UV. The antioxidative activities were evaluated using (1) 2,2-diphenyl-1-picrylhydrazyl (DPPH), (2) 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging and (3) ferric reducing antioxidant power (FRAP) methods. Results: All concentrations of herb extracts exhibited higher antioxidant capacities than extract from seedlings. Two antioxidant tests (DPPH, FRAP) showed that full water extract from herb had the highest antioxidant activity, while its non-protein fraction and protein fraction showed lower antioxidant activity. It was found that the full water extract from herb contained the highest concentrations of flavonoids and alkaloids when compared with other samples. Conclusion: Our findings suggest that chelidonine and coptisine especially could be responsible for the observed changes in the extract antioxidant activity, because these alkaloids were determined in the highest concentration in full water extract from herb. It cannot be also excluded that the observed variables values between extracts and their fractions from herb or from seedlings may also be the result of interactions between flavonoids and other chemical compounds.

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Evaluation of anti-inflammatory and analgesic activities of extracts from herb of Chelidonium majus L.

Cited by 31 publications

References 39 publications

Ecklonia cava (Laminariales) and Sargassum horneri (Fucales) synergistically inhibit the lipopolysaccharide-induced inflammation via blocking NF-κB and MAPK pathways

Ecklonia cava (Laminariales) and Sargassum horneri (Fucales) synergistically inhibit the lipopolysaccharide-induced inflammation via blocking NF-κB and MAPK pathways

Strong and Long-Lasting Antinociceptive and Anti-inflammatory Conjugate of Naturally Occurring Oleanolic Acid and Aspirin

Comparison of antioxidant activities of fractionated extracts from seedlings and herb ofChelidonium majusL. using DPPH, ABTS and FRAP methods

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