Evaluation of Anti-Oxidant Status and Radioprotective Activity of a Novel Anti-Cancer Drug in Mice

Abstract

Various approaches have been developed for diminishing the effects of radiation on normal tissues or enhancing tumor cell killing by ionizing radiation. Recently, there has been an increase in the interest in research on synthetic and/or natural radioprotective agents. An important potential use for these agents is to modify and improve the outcome of radiation therapy. The aim of this study was to examine the potential radioprotective role and antioxidant potency of the novel synthetic anticancer agent, quinoline sulfonamide (PIQSA) against tissue injury and oxidative stress induced by the exposure to gamma radiation and/or incidence of cancer in experimental animals. Mice (normal and bearing solid tumors) administered PIQSA (0.350 mg/kg body weight ip. three times a week for 21 days. At the last week of 30 days experimental period, an animal group was subjected to three successive doses of γ-radiation each of 2 Gy; another group was treated with combined administration of PIQSA 20 minutes before γ-irradiation. Some biochemical parameters (LPx, GSH, SOD, and CAT in liver homogenates, also plasma lipid profile (total lipids, total cholesterol, total triglycerides (TG), HDLc and LDLc were measured. To examine any adverse effect which could be attained by chemical treatment, liver enzymes (AST, ALT), and kidney function (creatinine and urea) were estimated in blood plasma, in addition to examination of some haematological indexes. The results indicated that the deleterious effects due to exposure to γ-radiation, and/or incidence of cancer on most of the estimated parameters could be controlled to a certain extent by administration of PIQSA to animals prior to irradiation. The results also confirmed that there were no significant adverse effects on mice due to the treatment with this chemical compound

Low dose X –ray effects on catalase activity in animal tissue

“…Exposure of living organisms to low-dose ionizing radiationstill considered a new radiobiological concept -could trigger various metabolic reactions that help cells to defend against oxidative stress such as that related to hydrogen peroxide -enhanced following water radiolysis, often generating the indirect effect of radiations. Hydrogen peroxide is highly deleterious to the cell and its accumulation causes oxidation of cellular targets such as DNA, proteins, and lipids leading to mutagenesis and cell death [9][10][11]. In the context of food preservation, this study was intended to investigate the effect of low-dose X ray-irradiation upon the activity of catalase (CAT) in freshly excised chicken tissues (liver, kidney, brain, muscle).…”

Comparative physiological and biochemial effects of CuO NPs and bulk CuO phytotoxicity onto the maize (Zea mays) seedlings

“…Oxidized lipids in addition to being synthesized in a specific and controlled manner by lipoxygenase (LOX), the non-enzymatic peroxidation of lipids could be mediated by carbon-and oxygen-centered radicals. Like all radical reactions, this process can be broken down into three discrete phases: initiation, propagation, and termination (Yousri et al, 2011). Yet, the substrate scope and general mechanism of lipid peroxidation is largely the same in both cases.…”

The Cancer-Protective Potential of Protocatechuic Acid: A Narrative Review

“…Cancer cells are characterized by higher amounts of ROS than healthy cells. They are responsible for maintaining the cancer phenotype as they constitute signaling molecules involved in regulating cell proliferation, apoptosis, and gene expression through the activation of transcription factors [59,60].…”