Evaluation of anti-proliferative activity of medicinal plants used in Asian Traditional Medicine to treat cancer

Siew, Yin-Yin; Hc, Yew; Neo, Sy; Sv, Seow; Sm, Lew; Lim, Shimin; Cse, Lim; Yc, Ng; Seetoh, Wei-Guang; Ali, Azhar; Tan, Chao; Koh, HL

doi:10.1016/j.jep.2018.12.040

Cited by 42 publications

(20 citation statements)

References 115 publications

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“…C. nutans now becomes a multifunctional plant that draws attention of scientists in various research areas. A bunch of reviews on the detailed phytochemistry and pharmacology of C. nutans have been provided [ 1 , 4 , 8 , 9 ]. Here we intend to focus on recent progress of the anticancer activity of C. nutans .…”

Section: Introductionmentioning

confidence: 99%

Recent Advancement in Anticancer Activity of Clinacanthus nutans (Burm. f.) Lindau

Lin

Chen

Lung

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Clinacanthus nutans is a traditional medicinal herb that is applied for the therapy of snake bites, skin infection, herpes infection, burns, scalds, dysentery, and diabetes. Clinacanthus nutans is also used to treat several cancers, including breast, cervical, colon, gastric, head and neck, liver, lung, pancreatic, and skin cancers, as well as lymphoma and leukemia; however, the underlying mechanisms of its anticancer activity remained undetermined. We searched PubMed and Google with key words “Clinacanthus nutans and cancer” and collected recent papers of Clinacanthus nutans with anticancer activity. We focused on the preparation, effects, and action mechanisms of Clinacanthus nutans extracts on various types of cancers. We hope that this mini review can help update our knowledge about active components, effects, and molecular mechanisms of extracts from this promising herb Clinacanthus nutans for ongoing studies and speed up its clinical application in the future.

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Section: Introductionmentioning

confidence: 99%

Recent Advancement in Anticancer Activity of Clinacanthus nutans (Burm. f.) Lindau

Lin

Chen

Lung

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Human monocytic cell lines such as U937 differentiated with inflammatory stimuli like phorbol 12myristate 13-acetate (PMA) offer a model for studying macrophage function [24][25][26]. We have previously reported in an ethnobotanical survey that V. trifolia was one of the fresh medicinal plants commonly used in Singapore [27] and leaf extracts of V. trifolia prepared by different extraction methods and solvents exhibited promising anti-proliferative activity in multiple cancer cell lines [28]. This study aimed to investigate the effects of various V. trifolia leaf extracts prepared by different extraction methods namely Soxhlet, ultrasonication, and maceration in various solvents, on cytokine production in PMA-differentiated U937 macrophages, and to isolate and identify phytoconstituents from the most active leaf extract.…”

Section: Introductionmentioning

confidence: 99%

Effects of Vitex trifolia L. leaf extracts and phytoconstituents on cytokine production in human U937 macrophages

Wee

Neo

Singh

et al. 2020

BMC Complement Med Ther

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Background: Dysregulation of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) form the basis of immune-mediated inflammatory diseases. Vitex trifolia L. is a medicinal plant growing in countries such as China, India, Australia and Singapore. Its dried ripe fruits are documented in Traditional Chinese Medicine to treat ailments like rhinitis and dizziness. Its leaves are used traditionally to treat inflammation-related conditions like rheumatic pain. Objective: This study aimed to investigate the effects of V. trifolia leaf extracts prepared by different extraction methods (Soxhlet, ultrasonication, and maceration) in various solvents on cytokine production in human U937 macrophages, and identify phytoconstituents from the most active leaf extract. Methods: Fresh leaves of V. trifolia were extracted using Soxhlet, ultrasonication, and maceration in hexane, dichloromethane, methanol, ethanol or water. Each extract was evaluated for its effects on TNF-α and IL-1β cytokine production by enzyme-linked immunosorbent assay in lipopolysaccharide-stimulated human U937 macrophages. The most active extract was analyzed and further purified by different chemical and spectroscopic techniques. Results: Amongst 14 different leaf extracts investigated, extracts prepared by ultrasonication in dichloromethane and maceration in ethanol were most active in inhibiting TNF-α and IL-1β production in human U937 macrophages. Further purification led to the isolation of artemetin, casticin, vitexilactone and maslinic acid, and their effects on TNF-α and IL-1β production were evaluated. We report for the first time that artemetin suppressed TNF-α and IL-1β production. Gas chromatography-mass spectrometry analyses revealed the presence of eight other compounds. To the best of our knowledge, this is the first report of butylated hydroxytoluene, 2,4-di-tertbutylphenol, campesterol and maslinic acid in V. trifolia leaf extracts.

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“…To limit protein intake also as it is precancerous according to studies that linked it to breast and colon cancers. Siew et al (2019) in Singapore declared a new scientific evidence for traditional use of local medicinal plant; Clausena lansium, Leea indica, Pereskia bleo, Strobilanthes crispus, Vernonia amygdalina and Vitex trifolia in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Carcinogenic Agents and Non Traditional Treatment

Morsy

Khalil

Moneim

2020

Journal of the Egyptian Society of Parasitology

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Evaluation of anti-proliferative activity of medicinal plants used in Asian Traditional Medicine to treat cancer

Cited by 42 publications

References 115 publications

Recent Advancement in Anticancer Activity of Clinacanthus nutans (Burm. f.) Lindau

Recent Advancement in Anticancer Activity of Clinacanthus nutans (Burm. f.) Lindau

Effects of Vitex trifolia L. leaf extracts and phytoconstituents on cytokine production in human U937 macrophages

Carcinogenic Agents and Non Traditional Treatment

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