Recent Advancement in Anticancer Activity of Clinacanthus nutans (Burm. f.) Lindau

Lin, Chung-Ming; Chen, Hsin-Han; Lung, Chi-Wen; Chen, Hui-Jye

doi:10.1155/2021/5560502

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…In an experimental study conducted in 2019, CN ethyl-acetate fractions (CNEAF) were found to induce reactive oxygen species (ROS)dependent autophagy and apoptosis of HCT116 human colorectal cancer cells (11). Similar observations were made where CNEAF induced autophagy and apoptosis, increased ROS levels, dissipated mitochondrial membrane potential, increased expression of Bax, and decreased the expression of Bcl-2 and Bcl-X2 in HCT116 cell lines (12). In an in vitro investigation of the potential of CN against cancer, the chloroform extracts of CN were shown to inhibit the proliferation of 7 cancer cell lines including the human colon adenocarcinoma cell line (LS-174T) (13).…”

Section: Introductionmentioning

confidence: 63%

A Network Pharmacology Approach to Explore Clinacanthus Nutans on Colorectal Cancer

Abdulla,

Lim

2023

JUMMEC

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Network pharmacology is a discipline that investigates traditional herbal medications using bioinformatic tools like chemical, protein, gene, and disease databases, and cytoscape, by visualizing the complex network of interactions between the chemical constituents in the medications and their targets. Clinacanthus nutans (CN) is a traditionally used medicinal herb that has been suggested for its role in cancer treatment. The current study investigated the network pharmacology of CN bioactives as a prospect for the treatment of colorectal cancer. A series of database mining steps were performed to create lists of bioactives, their targets, and target-related diseases. The network was constructed using cytoscape. In this study, 8 bioactives, i.e. β-amyrin, betulin, isovitexin, linolenyl alcohol, lupeol, orientin, palmitic acid, vitexin) were identified which interacted with 46 different targets. β-amyrin was identified as the most potent bioactive with 29 targets.

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Section: Introductionmentioning

confidence: 63%

A Network Pharmacology Approach to Explore Clinacanthus Nutans on Colorectal Cancer

Abdulla,

Lim

2023

JUMMEC

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“…39 This medicinal plant contains various phytochemical constituents, including lupeol, β-sitosterol, stigmasterol, botulin, myricyl alcohol, and a range of C-glycosyl flavones such as vitexin, isovitexin, shaftoside, isomollupentin, orientin, and isoorientin. [40][41] Pharmacologically, the leaves of Clinacanthus nutans have shown a wide range of activities, including cholinergic modulation, cytotoxicity, anti-Papillomavirus infectivity, anti-inflammatory properties, virucidal activity against varicella-zoster virus and dengue virus type 2, and antioxidant protective effects against oxidativeinduced hemolysis. [41][42] Clinically, preparations of Clinacanthus nutans, as creams, have been successfully used in treating genital herpes and varicella-zoster lesions.…”

Section: Resultsmentioning

confidence: 99%

Traditional Healing Practices and Folk Medicines in Thailand: A Case Study of Huai Yot District, Trang Province

2024

TJNPR

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A traditional medical practitioner, also known as a traditional healer or folk healer, is acknowledged by their community for their skill in delivering health care using various procedures. 1,2 These methods include using plant, animal, and mineral materials. Their expertise is deeply rooted in the social, cultural, and religious contexts of the community, as well as in the prevalent understandings and attitudes toward health, mental well-being, and the origins of diseases and disabilities. [1][2][3] The World Health Organization (WHO) and other international organizations recognize the importance of traditional medicine and advocate for its integration into national healthcare systems. 2,[4][5][6] This recognition underscores its role in achieving global health goals, especially in areas lacking access to conventional medicine. It serves as a primary healthcare resource for millions, offering treatments that are accessible, affordable, and culturally familiar. [6][7][8][9] Beyond physical ailments, traditional medicine often addresses mental and spiritual well-being, reflecting a holistic approach to health. 3,7,8 Its impact extends to the pharmacological field, where many modern medicines originated in traditional remedies. [10][11][12] Integrating traditional and modern medicine can enrich healthcare systems, providing diverse treatment options and promoting patient autonomy.

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“…Traditionally, C. nutans has been used for treating bacterial and viral infections, scalds and burns, insect and snake bites, skin rashes, gout, and diabetes [ 2 ]. Several studies have demonstrated that it has several biological activities, including anticancer, antioxidant, antidiabetic, antiviral, anti-inflammatory, immunomodulatory, and neuromodulatory activities [ 1 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Antiviral and Immunomodulatory Activities of Clinacanthus nutans (Burm. f.) Lindau

Lin

Chen

Lung

et al. 2023

IJMS

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Clinacanthus nutans (Burm. f.) Lindau has been used as a traditional herbal medicine for treating snake bites, scalds, burns, and viral and bacterial infections. It has been attracting an increasing amount of attention because of its biological activities, including its antidiabetic, antioxidant, antibacterial, anticancer, anti-inflammatory, antiviral, and immunoregulatory activities. Here, we conducted a panoramic survey of the literature regarding the immunoregulatory, anti-inflammatory, and antiviral activities of C. nutans. We discovered that C. nutans extracts have virucidal activities against herpes simplex virus types 1 and 2, varicella-zoster virus, cyprinid herpesvirus 3, porcine reproductive and respiratory syndrome virus, mosquito-borne chikungunya virus, and potentially SARS-CoV-2; such activities likely result from C. nutans interfering with the entry, penetration, infection, and replication of viruses. We also reviewed the phytochemicals in C. nutans extracts that exhibit anti-inflammatory and immunoregulatory activities. This updated review of the antiviral, anti-inflammatory, and immunoregulatory activities of C. nutans may guide future agricultural practices and reveal clinical applications of C. nutans.

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Recent Advancement in Anticancer Activity of Clinacanthus nutans (Burm. f.) Lindau

Cited by 9 publications

References 36 publications

A Network Pharmacology Approach to Explore Clinacanthus Nutans on Colorectal Cancer

A Network Pharmacology Approach to Explore Clinacanthus Nutans on Colorectal Cancer

Traditional Healing Practices and Folk Medicines in Thailand: A Case Study of Huai Yot District, Trang Province

Antiviral and Immunomodulatory Activities of Clinacanthus nutans (Burm. f.) Lindau

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