Evaluation of anti ulcer activity of ethanolic root extract of Beta vulgaris in rats

Abstract

Background: Beta vulgaris (chenopodiacea) is a plant reported for its variety of ethnic medicinal uses. Hence we have planned to screen anti ulcer activity of root of the plant with the alcoholic extract. Root powders successively extracted with alcohol and were subjected for phytochemical screening to identify different phytoconstituents.Methods: Anti ulcer activity was evaluated in various animal models like pylorus ligation and ethanol induced ulcer models in rats.Results: Preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, carbohydrates, saponins, polyphenols. No mortality was observed with root extract up to maximum dose level of 4g/kg. Further alcoholic extract of 200 and 400mg/ kg / p.o significantly (p˂0.01) reduced the ulcer score, ulcer number, ulcer index, free acidity and total acidity in pylorus ligation and ethanol induced ulcer models in rats.Conclusions: The present study revealed that the root extract of Beta vulgaris has antiulcer activity.

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“…From the supernatant, aliquots (1 ml of each) were taken for the determination of pH, total and free acidity. Each stomach was examined for lesions in the forestomach portion and indexed according to the severity of the animals treated as follows 8 . Volume of Gastric Juice: The volume of gastric juice was measured by the method described 9 .…”

Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

“…The root decoction along with a small amount of vinegar is traditionally used for the treatment of ulcers and sores. The alcoholic root extract of B. vulgaris at a concentration of 200–400 mg/kg significantly decreased the ulcer index, ulcer score, total acidity, and maintains normal mucosa in pylorus ligation and ethanol-induced ulcer in rat models [ 116 , 117 ]. The active constituents in B. vulgaris are polyphenols, tannins, alkaloids, vitamins (e.g., C, B3, B6, B9), carotenoids, flavonoids, betacyanins, betaxanthins, betanin, and saponins, most likely have inhibitory effects on gastric mucosal injury [ 116 , 118 , 119 ].…”

“…The alcoholic root extract of B. vulgaris at a concentration of 200–400 mg/kg significantly decreased the ulcer index, ulcer score, total acidity, and maintains normal mucosa in pylorus ligation and ethanol-induced ulcer in rat models [ 116 , 117 ]. The active constituents in B. vulgaris are polyphenols, tannins, alkaloids, vitamins (e.g., C, B3, B6, B9), carotenoids, flavonoids, betacyanins, betaxanthins, betanin, and saponins, most likely have inhibitory effects on gastric mucosal injury [ 116 , 118 , 119 ]. Betalains (molecular formula: C 24 H 26 N 2 O 13 ) ( Figure 1 ), nitrogenous water-soluble compounds, are abundant in B. vulgaris which have strong therapeutic activity against inflammatory diseases.…”

Anti-ulcer Activity of Avocado Juice and Kiwi Juice on Indomethacin Induced Gastric Ulcer in Rats

“…The stomach of the sacrificed animals was removed and pinned flatly out flat on a cork surface, and the area of the ulcer on the stomach surface was calculated on the paper rulers scaled by mm 2 , as well, the ulcers on the stomach surface were macroscopically estimated. The gastric mucosal lesion is expressed regarding ulcer index (UI) accorded to Peskar et al 2002and Samyuktha et al (2017) depending on the calculation of each lesion severity using a 0-3 score system defined based on the length of the lesions, where severity factor 0 means no lesions; severity factor 1 indicates lesions less than 1 mm length; severity factor 2 refers to lesions of 2-4 mm in length, while severity factor 3 indicates lesions larger than 4 mm in length. The lesions score was calculated for each rat as the number of the lesions in the rat x their particular severity factor.…”