Evaluation of Anti-Ulcer Properties of the Stem-Bark Fractions of Khaya senegalensis (Desr.) A. Jussin Albino Rats

Abstract

Article history:preliminary evaluation of crude methanol stem-bark extract of the plant revealed potent antiulcer properties. 21 Although much progress has been made in the management of H. pylori infection in gastric ulcer due to the widespread use of antisecretory drugs and antibiotics, increasing antimicrobial resistance has posed a great threat to its eradication. 22 Furthermore, emerging causes of peptic ulcers other than H. pylori and NSAIDs are imposing diagnostic and therapeutic challenges. Therefore, the aim of this study was to investigate the anti-ulcer effects of the stem-bark fractions of K. senegalensis in rats.

A Review of the Phytochemistry and Pharmacology of the Medicinal Plant: Khaya Senegalensis (Desr.) A. Juss

“…Fractions (aqueous methanol, hexane and ethyl acetate) of the plant's crude methanol extract were found to significantly lower gastric ulcer indices at 400 and 800mg/kg when compared with ethanol treated group. The findings strongly suggested Khaya senegalensis has anti-ulcerative properties, which could be due to its anti-secretory and antioxidative activities reported in the study [39]. Investigation of the effect of piroxicam co-administration with ethanol stem-bark extract of Khaya senegalensis on gastrotoxicity in rats also showed that, the interaction of plant extract with piroxicam resulted in the gastroprotective beneficial effects [40].…”