Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn.

Dharmani, Poonam; Kuchibhotla, Vijay Kumar; Maurya, Rakesh; Srivastava, Sudhir; Sharma, Sharad; Palit, Gautam

doi:10.1016/j.jep.2004.02.029

Cited by 86 publications

(48 citation statements)

References 17 publications

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“…The result showed that the reference drug (omeprazole) offered better gastro-protection when compared to that offered by the different doses of the extract of the plant ( Table 2). The findings are in agreement with the works of [27], who evaluated the antiulcerogenic and antiulcer properties of Ocimum sativum (Linn.). Acetylsalicyclic acid (aspirin) is a non-steroidal inflammatory drug (NSAID), which produced ulcer lesions in the glandular part of the rat's stomach.…”

Section: Discussionsupporting

confidence: 92%

Antiulcerogenic Potentials of Fermented Aqueous Extract of <i>Pentaclethra macrophylla</i> (Benth) Seeds

Ugbogu¹,

Arunsi²,

O³

et al. 2017

AJBR

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Pentaclethra macrophylla popularly known as African oil bean is a member of the Leguminosae family.A decoction of fermented extract of the plant has been known to be effective in the management of malnutrition, gastrointestinal disorders and dental caries. This study evaluated the antiulcerogenic potentials of aqueous extract of fermented P. macrophylla seeds using acetic acid, aspirin, ethanol, indomethacin and pyloric ligation of ethanol induced ulcer models at the doses of 400 and 800mg/kg body weight. Omeprazole at 5mg/kg was used as a standard reference drug. The result of the acute toxicity test showed that up to 5,000mg/kg body weight of the extract did not cause any mortality of the animals. The different doses of the extract and the reference drug decreased significantly (p<0.05) the ulcer parameters in a dose-dependent manner in all the ulcer models. The degree of ulcer index for the negative control groups is in the order: Indomethacin (11.10±0.10) < Pyloric-ligation (11.57±0.06) < Aspirin (11.60±0.10)

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Section: Discussionsupporting

confidence: 92%

Antiulcerogenic Potentials of Fermented Aqueous Extract of <i>Pentaclethra macrophylla</i> (Benth) Seeds

Ugbogu¹,

Arunsi²,

O³

et al. 2017

AJBR

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“…It is a well-accepted model for the induction of gastric ulcer and provide both emotional stress as well as physiological stress to the animal. 15 The percentage of ulcer protection of Tulsi leaf extract 100mg/kg and 200mg/kg and standard drug ranitidine were almost comparable. Therefore, the results were suggestive of anti ulcerogenic activity of Ocimum sanctum at the dose100-200mg/kg.…”

Section: Discussionmentioning

confidence: 89%

Activity of Tulsi leaves (Ocimum sanctum linn) in protecting gastric ulcer in rats by cold restrain method

Vaseem

Ali

Afshan

2017

Int J Basic Clin Pharmacol

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Background: Tulsi (Ocimum sanctum L.) common household plant, a potent adaptogen has been used for its medicinal property for many years. It is known in Ayurveda as Incomparable one, Mother of medicine of Nature and The Queen of Herbs. The present study evaluated the stress induced anti-ulcer effect of tulsi leaves in albino rats.Methods: Albino rats were randomly, allocated to different experimental groups and aqueous leaf extract of Tulsi (Ocimum sanctum) is given for 7 days. Gastric ulcers were induced by cold restrain methods and results were compared with control using distilled water and standard drug Ranitidine.Results: The Anti-ulcer effect of aqueous extract of Tulsi was significant in a dose dependent manner with cold restraint model. The percentage of ulcer protection of Tulsi leaf extract at dose 100mg/kg is 68.85% and at dose of 200mg/kg showed 65.66% and the standard drug Ranitidine showed 78.23% ulcer protection which is significant (p <0.05).Conclusions: The study showed that when Tulsi (Ocimum sanctum) is given at dose 100-200mg/kg for 7 days i.e., pre-treatment in rats for anti-ulcer effect, it caused a significant reduction in the ulcer scores and ulcer index when compared with control group, as evidenced by the gross appearance and histological findings of gastric mucosa in rats. There were few signs of mucosal injury and the percentage of damage was less compared to control group. Serosal surface revealed very few dilated blood vessels and petechial hemorrhages and mucosal surface had few ulcers of varying sizes.

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“…OS has been reported to possess anticarcinogenic (Karthikeyan et al, 1999), antidiabetic (Gupta et al, 2006), antihelminthic (Asha et al, 2001), anti-inflammatory (Godhwani et al, 1987), antioxidative (Geetha & Vasudevan, 2004), antibacterial (Singh et al, 2005), antistress (Gupta et al, 2007), and antiulcer (Dharmani et al, 2004) properties. OS leaves contain 0.7% volatile oil comprising about 71% eugenol and 20% methyl eugenol.…”

Section: Original Articlementioning

confidence: 99%

Evaluation of ethanol leaf extract of Ocimum sanctum in experimental models of anxiety and depression

Chatterjee

Verma

Maurya

et al. 2011

Pharmaceutical Biology

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Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn.

Cited by 86 publications

References 17 publications

Antiulcerogenic Potentials of Fermented Aqueous Extract of <i>Pentaclethra macrophylla</i> (Benth) Seeds

Antiulcerogenic Potentials of Fermented Aqueous Extract of <i>Pentaclethra macrophylla</i> (Benth) Seeds

Activity of Tulsi leaves (Ocimum sanctum linn) in protecting gastric ulcer in rats by cold restrain method

Evaluation of ethanol leaf extract of Ocimum sanctum in experimental models of anxiety and depression

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