EVALUATION OF ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF XANTHONE ISOLATED FROM Orophea corymbosa LEAF

Cane, Hawa Purnama Celala Ary; Saidi, Nurdin; Mustanir, M.; Darusman, Dudung; Idroes, Rinaldi; Musman, Musri

doi:10.31788/rjc.2020.1345818

Cited by 7 publications

(7 citation statements)

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“…There are many reports on numerous pharmacological activities attributed to xanthones of natural origin, including anti-inflammatory [ 96 , 97 ], anti-Leptospira [ 98 ], anti-collagenase, anti-elastase, anti-hyaluronidase, anti-tyrosinase [ 99 ], anticancer [ 100 , 101 ], antidiabetic [ 102 , 103 ], and antifungal [ 104 ] activities, and many xanthones have been described as good bacterial inhibitors [ 105 , 106 , 107 , 108 ].…”

Section: Xanthonesmentioning

confidence: 99%

Phenolic Compounds in Bacterial Inactivation: A Perspective from Brazil

Kauffmann

Castro

2023

Antibiotics

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Phenolic compounds are natural substances that are produced through the secondary metabolism of plants, fungi, and bacteria, in addition to being produced by chemical synthesis. These compounds have anti-inflammatory, antioxidant, and antimicrobial properties, among others. In this way, Brazil represents one of the most promising countries regarding phenolic compounds since it has a heterogeneous flora, with the presence of six distinct biomes (Cerrado, Amazon, Atlantic Forest, Caatinga, Pantanal, and Pampa). Recently, several studies have pointed to an era of antimicrobial resistance due to the unrestricted and large-scale use of antibiotics, which led to the emergence of some survival mechanisms of bacteria to these compounds. Therefore, the use of natural substances with antimicrobial action can help combat these resistant pathogens and represent a natural alternative that may be useful in animal nutrition for direct application in food and can be used in human nutrition to promote health. Therefore, this study aimed to (i) evaluate the phenolic compounds with antimicrobial properties isolated from plants present in Brazil, (ii) discuss the compounds across different classes (flavonoids, xanthones, coumarins, phenolic acids, and others), and (iii) address the structure–activity relationship of phenolic compounds that lead to antimicrobial action.

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Section: Xanthonesmentioning

confidence: 99%

Phenolic Compounds in Bacterial Inactivation: A Perspective from Brazil

Kauffmann

Castro

2023

Antibiotics

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“…Hasil tersebut menunjukkan bahwa ekstrak dan fraksi daun ghoune memiliki aktivitas antioksidan yang kuat. Jika nilai IC50 suatu sampel <100 µg/mL maka tergolong antioksidan yang kuat [26].…”

Section: Uji Aktivitas Antiradikalunclassified

“…Pengukuran kandungan fenolik total ditentukan dengan menggunakan metode Folin-Ciocalteau, kadar flavonoid ditentukan dengan menggunakan metode kolorimeter kompleks aluminium klorida, serta aktivitas antiradikal ditentukan dengan menggunakan metode DPPH. Fraksi etil asetat menunjukkan kadar fenolik dan flavonoid yang lebih tinggi dibandingkan ekstrak metanol, fraksi n-heksana dan fraksi air dengan kadar berturut-turut sebesar 28,476 g EAG/100 g sampel, 26,098 g EAG/100 g sampel, 15,905 g EAG/100 g sampel, 7,397 g EAG/100 g sampel untuk fenolik dan 49,812 g EK/100 g sampel, 44,198 g EK/100 g sampel, 41,898 g EK/100 g sampel dan 24,042 g EK/100 g sampel. Fraksi etil asetat menunjukkan aktivitas antioksidan yang sangat kuat dengan nilai IC50 sebesar 7,42 µg/mL.…”

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Penetapan Kadar Fenolik dan Flavonoid Ekstrak dan Fraksi Daun Ghoenu (Abelmoschus manihot L.) serta Uji Antiradikal Secara In Vitro

Yamin

2021

Pharmauho

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Ghoenu (Abelmoschus manihot L) merupakan tanaman tropis dari family Malvaceae yang dimasyakat selain digunakan sebagai sayuran juga digunakan sebagai bahan pengobatan tradisional. Secara empiris, rebusan daun ghoenu (A. manihot L) digunakan sebagai penurun kolesterol, analgetik, obat sakit ginjal, maag. Ghoenu mengandung metabolit sekunder antara lain flavonoid, asam amino, nukleosida, polisakarida, asam organik, steroid, minyak volatil. Tujuan penelitian ini adalah untuk mentukan kadar fenolik dan flavonoid ekstrak dan fraksi daun Ghoenu (Abelmoschus manihot L) serta uji antioksidan secara in vitro menggunakan DPPH (1-1-diphenyl-2-picrahidrazyl). Daun ghoenu diekstraksi dengan menggunakan metode maserasi. Pengukuran kandungan fenolik total ditentukan dengan menggunakan metode Folin-Ciocalteau, kadar flavonoid ditentukan dengan menggunakan metode kolorimeter kompleks aluminium klorida, serta aktivitas antiradikal ditentukan dengan menggunakan metode DPPH. Fraksi etil asetat menunjukkan kadar fenolik dan flavonoid yang lebih tinggi dibandingkan ekstrak metanol, fraksi n-heksana dan fraksi air dengan kadar berturut-turut sebesar 28,476 g EAG/100 g sampel, 26,098 g EAG/100 g sampel, 15,905 g EAG/100 g sampel, 7,397 g EAG/100 g sampel untuk fenolik dan 49,812 g EK/100 g sampel, 44,198 g EK/100 g sampel, 41,898 g EK/100 g sampel dan 24,042 g EK/100 g sampel. Fraksi etil asetat menunjukkan aktivitas antioksidan yang sangat kuat dengan nilai IC50 sebesar 7,42 µg/mL.

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“…It is even more popular nowadays because of the advantages of the natural product compared to synthetic material in offering safer, low side effects and green chemistry [7] materials. Many research reported either by in-silico [8,9] or invivo that the natural product from the plant contains various medical activities to be antimicrobial [10], antiviral [11], antibacterial [12][13][14], antibiofilm [15], antioxidant [16,17], and so on.…”

Section: Introductionmentioning

confidence: 99%

Analysis of flavonoid compounds of Orange (Citrus sp.) peel as anti-main protease of SARS-CoV-2: A molecular docking study

Maulydia

Tallei

Ginting

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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SARS-CoV-2 is a new type of coronavirus that causes COVID-19. This virus was first detected in the city of Wuhan, China, at the end of 2019, and until now, it has become a global pandemic. The FDA recently approved Vekluty (remdesivir) for adults and certain pediatric patients who have COVID-19 and are sick enough to require hospitalization. One of the potential drug target candidates for SARS-CoV-2 is the main protease (Mpro). The purpose of this study was to analyze the flavonoid compounds found in orange (Citrus sp.) peel to determine its potential as anti-Mpro through a molecular docking study. The compounds were initially screened for drug-like properties and then docked using Autodock Vina in the PyRx emulator software. The docking results were visualized using the BIOVIA Discovery Visualizer 2020. The result showed that the binding free energy of hesperidin (-8.6 kcal/mol) was higher than nelfinavir (-8.5 kcal/mol). In addition, hesperitin (-7.3 kcal/mol), sakuranetin (-7.1 kcal/mol), isosacuranetin (-7.2 kcal/mol) and tetra-o-methylscutallerin (-6.8 kcal/mol) exhibited lower binding free energy value than control. Based on these results, hesperidin has the potential as an inhibitor of the main protease’s SARS-CoV-2.

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EVALUATION OF ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF XANTHONE ISOLATED FROM Orophea corymbosa LEAF

Cited by 7 publications

References 0 publications

Phenolic Compounds in Bacterial Inactivation: A Perspective from Brazil

Phenolic Compounds in Bacterial Inactivation: A Perspective from Brazil

Penetapan Kadar Fenolik dan Flavonoid Ekstrak dan Fraksi Daun Ghoenu (Abelmoschus manihot L.) serta Uji Antiradikal Secara In Vitro

Analysis of flavonoid compounds of Orange (Citrus sp.) peel as anti-main protease of SARS-CoV-2: A molecular docking study

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