Evaluation of Antibacterial and Toxicological Effects of a Novel Sodium Silicate Complex

Vattem, Dhiraj; Maitin, Vatsala; Richardson, Charles

doi:10.3923/jm.2012.191.198

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…Many metal ions such as iron and zinc have been reported as bactericides [ 34 ]. Sodium [ 35 ] and SSC [ 36 ] have also been shown to inhibit bacteria growth. This suggests that SSC may not only attenuate the venom-induced hemorrhage, but also prevent the bacterial infection complicating P. mucrosquamatus envenoming.…”

Section: Discussionmentioning

confidence: 99%

Effects of Sodium Silicate Complex against Hemorrhagic Activities Induced by Protobothrops mucrosquamatus Venom

Chen

Wang

Huang

et al. 2021

Toxins

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Protobothrops mucrosquamatus poses a serious medical threat to humans in Southern and Southeastern Asia. Hemorrhage is one of the conspicuous toxicities related to the pathology of P. mucrosquamatus envenoming. Previous in vitro and in vivo studies showed that a silica-derived reagent, sodium silicate complex (SSC), was able to neutralize hemorrhagic and proteolytic activities induced by pit viper venoms, including Crotalus atrox, Agkistrodoncontortrix contortrix and Agkistrodon piscivorus leucostoma. In this study, we validated that SSC could neutralize enzymatic and toxic effects caused by the venom of P. mucrosquamatus. We found that SSC inhibited the hemolytic and proteolytic activities induced by P. mucrosquamatus venom in vitro. In addition, we demonstrated that SSC could block intradermal hemorrhage caused by P. mucrosquamatus venom in a mouse model. Finally, SSC could neutralize lethal effects of P. mucrosquamatus venom in the mice. Therefore, SSC is a candidate for further development as a potential onsite first-aid treatment for P. mucrosquamatus envenoming.

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Section: Discussionmentioning

confidence: 99%