Evaluation of antihyperglycaemic activity of Calotropis procera leaves extract on streptozotocin-induced diabetes in Wistar rats

Neto, Mário Correia Lima; Vasconcelos, Carlos Fernando Brasileiro de; Thijan, Valerium N.; Caldas, Germana Freire Rocha; Araújo, Alice V.; Costa‐Silva, João Henrique; Amorim, Elba Lúcia Cavalcanti de; Ferreira, Fabiano; Oliveira, Antônio Fernando Morais de; Wanderley, Almir Gonçalves

doi:10.1590/s0102-695x2013000600008

Cited by 29 publications

(14 citation statements)

References 22 publications

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“…The succulent leaves of Calotropis procera plant were collected from Nazareth (90 km southeast of Addis Ababa); it is located 8°33′0″ N Latitude, 39°16′0″ E Longitude at an elevation of 1,627 m with an average annual rainfall of 808 mm. The collected C. procera leaves were, identified by Botany Department, cleaned very well and dried by setting the temperature at 45 ± 1°C according to the method described by Netoa et al (2013). Then after, dried leaves of Calotropis procera ground into powder by using an electric blender and kept the powder under airtight container until next use.…”

Section: Methodsmentioning

confidence: 99%

Manufacture of fresh cheese using east African Calotropis procera leaves extract crude enzyme as milk coagulant

Abebe

Emire

2020

Food Science & Nutrition

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The present work was aimed to develop fresh cheese using the crude extract from calotropis procera leaves and thereby performed evaluating milk‐clotting activity and acute toxicity of crude extract. The extraction of coagulant was performed at 30, 45, and 60℃ using 2, 6, and 10 g of dried calotropis procera leaves, respectively. The highest yield of crude enzyme extract was acquired with 2 g and 30℃, and results were varied significantly (p < .05). The highest cheese yield and fastest clotting time were 17.89 kg cheese/100kg milk and 14:50 min acquired with 10 g C. procera powder at 60℃ extraction temperature, respectively. E. coli, total bacterial count, yeast, and mold microbial load detection were observed below the limit established by codex alimentarius. This study recommends that use of C. procera crude enzyme leaves extract can be used as alternate milk coagulant for production of fresh cheeses. Soft cheeses manufactured with calotropin enzyme as milk coagulant revealed no adverse effects of toxicity tested on albino rates to the highest dose.

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Section: Methodsmentioning

confidence: 99%

Manufacture of fresh cheese using east African Calotropis procera leaves extract crude enzyme as milk coagulant

Abebe

Emire

2020

Food Science & Nutrition

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“…Calotropis procera, Apocynaceae, is a wild perennial shrub that originated in African, Indian and Persian deserts (Neto et al, 2013). In these areas, the average annual rainfall is between 30 and 200 mm, or even less.…”

Section: Introductionmentioning

confidence: 99%

“…Further studies have shown that laticifer proteins are involved in the plant's defense against crop pests (Ramos et al, 2007;Ramos et al, 2010). Several reports in literature indicate that the plant contains various classes of secondary metabolites, including flavonoids, cardioactive glycosides, triterpenoids, alkaloids, resins, anthocyanins, tannins, saponins and proteolytic enzymes (Neto et al, 2013). C. procera is regenerated by seed and produces lots of small seeds that are dispersed by wind; nonetheless, its density is very low.…”

Section: Introductionmentioning

confidence: 99%

CARDINAL TEMPERATURES FOR GERMINATION OF THE MEDICINAL ANDDESERT PLANT, Calotropis procera

2015

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-Calotropis procera, Apocynaceae, is a wild perennial shrub that originated in the Persian deserts. It is known to provide key resources in degraded ecosystems to about 80 animal species. C. procera is regenerated by seed and produces lots of small seeds that are dispersed by wind; nonetheless, its density is very low. The purpose of this study is to estimate the cardinal temperatures including the base, optimum, and maximum temperatures of Calotropis procera looking at two different ecotypes in the Iranian desert. The germination behavior of C. procera seeds was tested at temperature regimens of 0, 5, 10, 15, 20, 25, 30, 35 and 40 o C and was analyzed using linear regression models. The rate of germination increased between base and optimum thermal conditions, and decreased between optimum and maximum thermal conditions. The base, optimum and maximum temperatures for germination of C. procera seeds were estimated at 19.10, 30.75 and 47.80 o C for the Fars and 20.00, 31.82 and 49.69 o C for the Zahedan desert, respectively. Temperature and germination were rated to determine the seeding dates of the C. procera. Overall, cardinal temperatures for germination were dependent on local climate characteristics for the range of adaptations in plant growth of the given species.

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“…Administration of methanolic and ethyl acetate extracts of the root, stem, and leaf of CP at 100 and 250 mg/kg doses for 14 days significantly attenuated hyperalgesia, tactile allodynia, and HbA1C% levels in STZ diabetic rats [32].…”

Section: Calotropisprocera (Cp)mentioning

confidence: 87%

Untitled

2017

MOJAP

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Diabetic peripheral neuropathy (DPN) is an unwanted side effect that usually occurs in both types of diabetes mellitus (DM). Like other diabetic complications, the cause of DPN is not clear. This review will provide an experimental evidences on some common phytochemicals that used for the prevention or treatment of DPN. This review will not be only useful to doctors in making decisions about the best available phytochemical therapeutic choices of DPN but also to avoid the side effects of pharmacological drugs.

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Evaluation of antihyperglycaemic activity of Calotropis procera leaves extract on streptozotocin-induced diabetes in Wistar rats

Cited by 29 publications

References 22 publications

Manufacture of fresh cheese using east African Calotropis procera leaves extract crude enzyme as milk coagulant

Manufacture of fresh cheese using east African Calotropis procera leaves extract crude enzyme as milk coagulant

CARDINAL TEMPERATURES FOR GERMINATION OF THE MEDICINAL ANDDESERT PLANT, Calotropis procera

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