Evaluation of Antihyperuricemic Activity of Shodhita Shilajatu on Potassium Oxonate Induced Hyperuricemic Rat Model

Abstract

Vatarakta a Mahavatavyadhi is a burning problem in present era. Here, both vata and rakta are responsible for complex effects in the joints. The status of Vatarakta (gout) is often compared with Gout in the allied sources due to the outstanding similarities. The present study has been conducted to evaluate Antihyperuricemic activity of Shodhita Shilajatu following its 7-days repeated oral administration on potassium oxonate induced hyperuricemic rat model. Antihyperuricemic activity of Shodhita (purified) Shilajatu (Asphaltum punjabinum -Black bitumen or mineral pitch) was studied in hyperuricemia induced in wistar albino rats using potassium oxonate. The uric acid levels in serum and urine were measured and histopathological study of Kidneys was evaluated. In potassium oxonate induced hyperuricemia, standard drug allopurinol and trial drug significantly lowered the serum uric acid levels. Urine analysis shows the presence of uric acid crystals in both the groups. When the results were compared it was found to be higher in the test group which suggests better uric acid excretion efficacy of Shilajatu. Histological examination of the kidney sections from all the groups showed moderate changes in Potassium oxonate administered control group which were significantly reduced in reference standard and moderately reversed in test drug administered group.